Usha Sethuraman
YOU?
Author Swipe
View article: Social Determinants of Health Patterns in Children with Severe Disease Due to SARS-CoV-2 Infection—An Exploratory Approach
Social Determinants of Health Patterns in Children with Severe Disease Due to SARS-CoV-2 Infection—An Exploratory Approach Open
Background/Objectives: Research on the association of adverse social determinants of health (SDOH) with severe pediatric coronavirus disease (COVID-19) is limited. We examined associations between SDOH patterns and COVID-19 severity in chi…
View article: Trends in Pediatric Diphenhydramine Cases Reported to US Poison Centers (2014–2023)
Trends in Pediatric Diphenhydramine Cases Reported to US Poison Centers (2014–2023) Open
BACKGROUND AND OBJECTIVE Recent toxicosurveillance trends indicate an increase in intentional pediatric diphenhydramine ingestions, raising concerns about accessibility, toxicity, social media influence, and the need for appropriate harm r…
View article: Multiplexed Salivary miRNA Quantification for Predicting Severe COVID-19 Symptoms in Children Using Ligation-RPA Amplification Assay
Multiplexed Salivary miRNA Quantification for Predicting Severe COVID-19 Symptoms in Children Using Ligation-RPA Amplification Assay Open
Most children with SARS-CoV-2 have mild or asymptomatic symptoms, but some develop severe complications. Early identification of high-risk cases is crucial for timely intervention. Alterations in salivary microRNA (miRNA) levels serve as b…
View article: Generative Large Language Model—Powered Conversational AI App for Personalized Risk Assessment: Case Study in COVID-19
Generative Large Language Model—Powered Conversational AI App for Personalized Risk Assessment: Case Study in COVID-19 Open
Background Large language models (LLMs) have demonstrated powerful capabilities in natural language tasks and are increasingly being integrated into health care for tasks like disease risk assessment. Traditional machine learning methods r…
View article: Generative Large Language Model—Powered Conversational AI App for Personalized Risk Assessment: Case Study in COVID-19 (Preprint)
Generative Large Language Model—Powered Conversational AI App for Personalized Risk Assessment: Case Study in COVID-19 (Preprint) Open
BACKGROUND Large language models (LLMs) have demonstrated powerful capabilities in natural language tasks and are increasingly being integrated into health care for tasks like disease risk assessment. Traditional machine learning methods …
View article: Generative LLM Powered Conversational AI Application for Personalized Risk Assessment: A Case Study in COVID-19
Generative LLM Powered Conversational AI Application for Personalized Risk Assessment: A Case Study in COVID-19 Open
Large language models (LLMs) have shown remarkable capabilities in various natural language tasks and are increasingly being applied in healthcare domains. This work demonstrates a new LLM-powered disease risk assessment approach via strea…
View article: Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2
Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2 Open
14% of children with SARS-CoV-2 infections had radiographic pneumonia. Hypoxemia, cough, higher temperature, and older age were associated with pneumonias. In children tested, SARS-CoV-2 test results were not associated with radiographic p…
View article: Saliva microRNA Profile in Children with and without Severe SARS-CoV-2 Infection
Saliva microRNA Profile in Children with and without Severe SARS-CoV-2 Infection Open
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) may impair immune modulating host microRNAs, causing severe disease. Our objectives were to determine the salivary miRNA profile in children with SARS-CoV-2 infection at present…
View article: Comparison of anaphylaxis epidemiology between urban and suburban pediatric emergency departments
Comparison of anaphylaxis epidemiology between urban and suburban pediatric emergency departments Open
Background Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. To date, there are no published data on epidemiology of pediatric anaphylaxis in Michigan. Our objective was to describe and compare the time…
View article: Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection
Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection Open
Importance Little is known about the risk factors for, and the risk of, developing post–COVID-19 conditions (PCCs) among children. Objectives To estimate the proportion of SARS-CoV-2–positive children with PCCs 90 days after a positive tes…
View article: Pediatric Melatonin Ingestions — United States, 2012–2021
Pediatric Melatonin Ingestions — United States, 2012–2021 Open
Melatonin is an endogenous neurohormone that regulates the sleep-wake cycle (1). It is used therapeutically for insomnia in adults and for primary sleep disorders in children (2). Melatonin is regulated by the Food and Drug Administration …
View article: Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments
Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments Open
In this study, approximately 3% of SARS-CoV-2-positive youths tested in EDs experienced severe outcomes within 2 weeks of their ED visit. Among children discharged home from the ED, the risk was much lower. Risk factors such as age, underl…
View article: Combined Hyperglycemic Hyperosmolar Syndrome and Diabetic Ketoacidosis Associated with COVID-19 in a Pediatric Patient
Combined Hyperglycemic Hyperosmolar Syndrome and Diabetic Ketoacidosis Associated with COVID-19 in a Pediatric Patient Open
Although most children with coronavirus disease 2019 (COVID-19) are asymptomatic or only with mild symptoms, many symptomatic children still require admission to the intensive care unit. Multiple cases of diabetic ketoacidosis (DKA) and hy…
View article: Reducing Computed Tomography Scan Utilization for Pediatric Minor Head Injury in the Emergency Department: A Quality Improvement Initiative
Reducing Computed Tomography Scan Utilization for Pediatric Minor Head Injury in the Emergency Department: A Quality Improvement Initiative Open
Background The validated Pediatric Emergency Care Applied Research Network (PECARN) prediction rules are meant to aid clinicians in safely reducing unwarranted imaging in children with minor head injuries (MHI). Even so, computed tomograph…
View article: Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever
Urinary Tract Infection in Febrile Children with Sickle Cell Disease Who Present to the Emergency Room with Fever Open
Sickle cell disease (SCD) patients are thought to be at higher risk for urinary tract infections (UTIs) compared to the general population secondary to increased sickling, abnormal urinary acidification, and an inability to concentrate the…
View article: Prescription Errors Before and After Introduction of Electronic Medication Alert System in a Pediatric Emergency Department
Prescription Errors Before and After Introduction of Electronic Medication Alert System in a Pediatric Emergency Department Open
Objectives Prescription errors occur frequently in pediatric emergency departments ( PED s).The effect of computerized physician order entry ( CPOE ) with electronic medication alert system ( EMAS ) on these is unknown. The objective was t…