Introduction Deterioration in knee extensor function is significantly related to decline in functional mobility, stability and proprioception increasing risk of injury and falls. Coactivation of the hamstrings has been reported in normal and neuromuscular conditions during knee extension emphasizing coordinated muscle activation through range of motion. This study evaluated a prototype compressed sensing accelerated 4D Flow (CS-4DFlow) sequence for volumetric MRI strain mapping of the entire thigh during isometric…

Background/Objectives: Several sequences for magnetization transfer contrast (MTC) imaging are available, from indices of MTC ranging from quantitative magnetization transfer (qMT) that yields the macromolecular fraction to simple ratios of signal intensities with and without a magnetization transfer (MT) pulse. Aging muscle undergoes changes including an increase in fibrosis and adipose accompanied by fiber atrophy and loss. The objective is to evaluate five MTC sequences to study age-related differences in muscl…

This review is focused on the current status of quantitative MRI (qMRI) of skeletal muscle. The first section covers the techniques of qMRI in muscle with the focus on each quantitative parameter, the corresponding imaging sequence, discussion of the relation of the measured parameter to underlying physiology/pathophysiology, the image processing and analysis approaches, and studies on normal subjects. We cover the more established parametric mapping from T1-weighted imaging for morphometrics including image segme…

This review is focused on the current status of quantitative MR (qMR) of skeletal muscle. The first section covers the techniques of qMR in muscle with the focus on each quantitative parameter, the corresponding imaging sequence, discussion of the relation of the measured parameter to underlying physiology/ pathophysiology, the image processing and analysis approaches, and studies on normal subjects. We cover the more established parametric mapping from T1 weighted imaging for morphometrics including image segment…

Abstract Purpose Implement STEAM‐DTI to model time‐dependent diffusion eigenvalues using the random permeable barrier model (RPBM) to study age‐related differences in the medial gastrocnemius (MG) muscle. Validate diffusion model‐extracted fiber diameter for histological assessment. Methods Diffusion imaging at different diffusion times ( Δ ) was performed on seven young and six senior participants. Time‐dependent diffusion eigenvalues ( λ 2 ( t ), λ 3 ( t ), and D ⊥ ( t ); average of λ 2 ( t ) and λ 3 ( t )) were…