Uazman Alam
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View article: Sleep problems and associated risk factors among physicians in Bangladesh: a protocol for systematic review and meta-analysis of observational cross-sectional studies
Sleep problems and associated risk factors among physicians in Bangladesh: a protocol for systematic review and meta-analysis of observational cross-sectional studies Open
Introduction Sleep problems are an escalating global health concern, with prevalence estimates ranging from 8.3% to 45%. Physicians are disproportionately affected, with rates around 44% compared with 36% in the general population. In Bang…
View article: Impact of individualized and structured aerobic exercise on clinical outcomes in pediatric congenital heart diseases with post-surgical rehabilitation: a meta-analysis
Impact of individualized and structured aerobic exercise on clinical outcomes in pediatric congenital heart diseases with post-surgical rehabilitation: a meta-analysis Open
Background Children with congenital heart defects (CHD) commonly experience decreased exercise capacity due to structural heart abnormalities, surgical interventions, and parental-and physician-imposed activity restrictions. This reduced a…
View article: Synergistic associations of metformin and <scp>GLP</scp> ‐1 receptor agonist use with adiposity‐related cancer incidence in people living with type 2 diabetes
Synergistic associations of metformin and <span>GLP</span> ‐1 receptor agonist use with adiposity‐related cancer incidence in people living with type 2 diabetes Open
Background Metformin and glucagon‐like peptide‐1 receptor agonists ( GLP ‐1 RAs ) may reduce the risk of adiposity‐related cancers in patients with type 2 diabetes ( T2D ). The potential synergistic effects of these treatments on cancer in…
View article: Increased cardiovascular risk in people with type 2 diabetes and periodontitis: an analysis from a global real-world federated database
Increased cardiovascular risk in people with type 2 diabetes and periodontitis: an analysis from a global real-world federated database Open
Introduction Type 2 diabetes (T2D) is a global health challenge conferring significant morbidity and mortality with accelerated cardiovascular, renovascular and cerebrovascular disease. Periodontitis has a higher prevalence in people with …
View article: Relative efficacy of <scp>GLP</scp> ‐1 and <scp>GLP</scp> ‐1/ <scp>GIP</scp> receptor agonists in the prevention of alcohol‐use disorders using a target trial emulation approach
Relative efficacy of <span>GLP</span> ‐1 and <span>GLP</span> ‐1/ <span>GIP</span> receptor agonists in the prevention of alcohol‐use disorders using a target trial emulation approach Open
Aims There is growing evidence that the GLP‐1 system is implicated in alcohol and other substance use disorders, and that GLP‐1‐based therapies may have therapeutic relevance in alcohol use disorder (AUD). We aimed to determine the impact …
View article: GROK: From Quantitative Biomarkers to Qualitative Diagnosis via a Grounded MLLM with Knowledge-Guided Instruction
GROK: From Quantitative Biomarkers to Qualitative Diagnosis via a Grounded MLLM with Knowledge-Guided Instruction Open
Multimodal large language models (MLLMs) hold promise for integrating diverse data modalities, but current medical adaptations such as LLaVA-Med often fail to fully exploit the synergy between color fundus photography (CFP) and optical coh…
View article: Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease
Metabolic bariatric surgery is associated with reduced adverse hepatic and extrahepatic outcomes, and lower all‐cause mortality, in patients with steatotic liver disease Open
Aim Metabolic bariatric surgery (MBS) improves histological endpoints in steatotic liver disease (SLD), but data on longer‐term clinical outcomes in this population are scarce. Here, we assessed the impact of MBS on hepatic and extrahepati…
View article: Unraveling Delayed Puberty: A Rare Case of Congenital Hypogonadotropic Hypogonadism Masked by Celiac Disease and Plummer–Vinson Syndrome
Unraveling Delayed Puberty: A Rare Case of Congenital Hypogonadotropic Hypogonadism Masked by Celiac Disease and Plummer–Vinson Syndrome Open
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that results in delayed puberty and infertility due to impaired secretion of gonadotropin‐releasing hormone (GnRH). Here, we present a case of a 25‐year‐old male with a know…
View article: Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis
Efficacy and safety of lemborexant in patients with insomnia: a systematic review and meta-analysis Open
Lemborexant demonstrates significant efficacy in improving sleep parameters in patients with insomnia and has a generally favorable safety profile. These findings support its role as an effective pharmacological option. Further high-qualit…
View article: Target Trial Emulations of <scp>GLP</scp> ‐1 and Dual <scp>GLP</scp> ‐1/ <scp>GIP</scp> Agonists to Reduce Major Adverse Liver Outcomes in Type 2 Diabetes
Target Trial Emulations of <span>GLP</span> ‐1 and Dual <span>GLP</span> ‐1/ <span>GIP</span> Agonists to Reduce Major Adverse Liver Outcomes in Type 2 Diabetes Open
Background Clinical trials suggest GLP‐1 receptor agonists (RAs) and dual glucagon‐like peptide‐1 (GLP‐1)/glucose‐dependent insulinotropic polypeptide (GIP) RAs improve metabolic dysfunction associated with steatohepatitis (MASH) in patien…
View article: Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project
Clinical risk phenotypes in diabetes and their associations with adverse cardiovascular events: A report from the Silesia Diabetes‐Heart Project Open
Aims Diabetes is characterized by clinical heterogeneity. This study aimed to identify different clinical phenotypes of real‐world people with diabetes and to assess their associations with major adverse cardiovascular events (MACEs). Meth…
View article: Efficacy and Safety of Oral Immunotherapy for Peanut Allergy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Oral Immunotherapy for Peanut Allergy: A GRADE-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Introduction: Peanut allergy is a common and potentially life-threatening condition affecting up to 2% of children in Western countries. Management traditionally relied on avoidance, but in 2020, the FDA-approved peanut oral immunotherapy …
View article: Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia
Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia Open
Fibromyalgia syndrome (FM) is characterized by widespread pain and fatigue. People living with FM also experience tactile allodynia, cold-evoked pain, paraesthesia and dysaesthesia. There is evidence of small fibre neuropathy and hyperexci…
View article: Abdominal cocoon syndrome: a case report
Abdominal cocoon syndrome: a case report Open
Abdominal cocoon syndrome (ACS) is a rare cause of intestinal obstruction characterized by the encasement of the small intestine in a fibrocollagenous membrane, making preoperative diagnosis challenging. We present the case of a 15-year-ol…
View article: The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database
The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database Open
Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. These findings emphasise the urgent need for earlier detection, aggressive risk factor …
View article: Depression among medical students in Bangladesh: a systematic review and meta-analysis protocol on prevalence and associated factors
Depression among medical students in Bangladesh: a systematic review and meta-analysis protocol on prevalence and associated factors Open
Introduction Depression, affecting 350 million people globally, is notably prevalent among medical students, particularly in South Asia, including Bangladesh. Despite several studies, no meta-analysis has systematically examined the preval…
View article: Prevalence of suicidal behaviours among medical students in South Asia in the 1<sup>st</sup> quarter of the 21<sup>st</sup> century: a systematic review and meta-analysis protocol
Prevalence of suicidal behaviours among medical students in South Asia in the 1<sup>st</sup> quarter of the 21<sup>st</sup> century: a systematic review and meta-analysis protocol Open
Background Medical students in South Asia face intense mental and psychosocial challenges, increasing their vulnerability to suicidal behaviours. Despite sporadic studies, no comprehensive meta-analysis has yet examined the prevalence and …
View article: Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project
Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project Open
People with DKD, with reduced eGFR or both reduced eGFR and elevated UACR, but not with elevated UACR alone, are at higher CV risk. Personalizing therapy based on clinic-based renal phenotyping can facilitate the initiation of CV disease m…
View article: Comparative efficacy and safety of no-touch versus conventional vein harvesting techniques in coronary artery bypass grafting: a systematic review and meta-analysis
Comparative efficacy and safety of no-touch versus conventional vein harvesting techniques in coronary artery bypass grafting: a systematic review and meta-analysis Open
Objective This meta-analysis aims to compare the clinical outcomes of the no-touch (NT) and conventional (CON) vein harvesting techniques in patients undergoing coronary artery bypass grafting (CABG). Methods We conducted a systematic revi…
View article: Effects of hormone replacement therapy (HRT) in midlife women with type 2 diabetes: a retrospective cohort study
Effects of hormone replacement therapy (HRT) in midlife women with type 2 diabetes: a retrospective cohort study Open
Introduction: There is a lack of outcome data relating to HRT in midlife women with type 2 diabetes (T2DM), particularly concerning cardiovascular risk, gynaecological and oestrogen-related cancers.1 Methods: We performed an active compara…
View article: HMSViT: A Hierarchical Masked Self-Supervised Vision Transformer for Corneal Nerve Segmentation and Diabetic Neuropathy Diagnosis
HMSViT: A Hierarchical Masked Self-Supervised Vision Transformer for Corneal Nerve Segmentation and Diabetic Neuropathy Diagnosis Open
Diabetic Peripheral Neuropathy (DPN) affects nearly half of diabetes patients, requiring early detection. Corneal Confocal Microscopy (CCM) enables non-invasive diagnosis, but automated methods suffer from inefficient feature extraction, r…
View article: Efficacy and Safety of Prothrombin Complex Concentrate Compared to Fresh Frozen Plasma in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Prothrombin Complex Concentrate Compared to Fresh Frozen Plasma in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Coagulopathy and bleeding are common complications following cardiac surgery, often requiring the use of hemostatic agents such as prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP). This systematic review and meta-analysis…
View article: The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real‐world retrospective cohort study
The impact of insulin pump therapy compared to multiple daily injections on complications and mortality in type 1 diabetes: A real‐world retrospective cohort study Open
Aims Clinical trials have demonstrated the benefits of insulin pump therapy compared with multiple daily injections (MDI) in type 1 diabetes. However, contemporaneous real‐world data are limited. This study investigated the real‐world impa…
View article: The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells
The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells Open
Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism remains unclear. Here, we found that …
View article: P170 Risk of cardiovascular events and cancer following the initiation of interleukin-17 inhibitors versus tumour necrosis factor inhibitors in spondyloarthritis
P170 Risk of cardiovascular events and cancer following the initiation of interleukin-17 inhibitors versus tumour necrosis factor inhibitors in spondyloarthritis Open
Background/Aims Spondyloarthritis (SpA) is associated with increased risk of cardiovascular disease (CVD) and cancer. Interleukin-17 inhibitors (IL-17i) are highly effective for SpA, specifically psoriatic arthritis (PsA) and axial spondyl…