Victor Darley‐Usmar
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View article: Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
Supplementary Figures and Table
View article: Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology
Transmitophagy in the heart: An overview of molecular mechanisms and implications for pathophysiology Open
View article: TMET-44. ST6Gal1 Mediated α2,6 Sialylation Regulates Glioblastoma Metabolism and GLUT3 Dynamics
TMET-44. ST6Gal1 Mediated α2,6 Sialylation Regulates Glioblastoma Metabolism and GLUT3 Dynamics Open
Unlike other post translational modifications like phosphorylation, glycosylation has often been overlooked as a critical regulator of cell signaling in cancers, including brain tumors. One form of glycosylation is sialylation, or the addi…
View article: Brain Transcriptome Changes Associated With an Acute Increase of Protein O‐ <scp>GlcNAcylation</scp> and Implications for Neurodegenerative Disease
Brain Transcriptome Changes Associated With an Acute Increase of Protein O‐ <span>GlcNAcylation</span> and Implications for Neurodegenerative Disease Open
Enhancing protein O‐GlcNAcylation by pharmacological inhibition of the enzyme O‐GlcNAcase (OGA) has been considered as a strategy to decrease tau and amyloid‐beta phosphorylation, aggregation, and pathology in Alzheimer's disease (AD). The…
View article: Wheat-Based Protein Slows Disease Progression in <i>Pkd1</i> Knockout Mice
Wheat-Based Protein Slows Disease Progression in <i>Pkd1</i> Knockout Mice Open
Dietary load and composition are known contributors that accelerate cyst growth in polycystic kidney disease (PKD). High protein intake, which increases amino acid burden in the kidneys, is one such factor. Despite identical protein load, …
View article: Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed Open
Mitochondria play a crucial role in brain aging due to their involvement in bioenergetics, neuroinflammation and brain steroid synthesis. Mitochondrial dysfunction is linked to age-related neurodegenerative diseases, including Alzheimer’s …
View article: Impact of<i>O</i>-GlcNAcylation elevation on mitophagy and glia in the dentate gyrus
Impact of<i>O</i>-GlcNAcylation elevation on mitophagy and glia in the dentate gyrus Open
O -GlcNAcylation is a dynamic and reversible protein post-translational modification of serine or threonine residues which modulates the activity of transcriptional and signaling pathways and controls cellular responses to metabolic and in…
View article: Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice
Alpha-synuclein preformed fibril-induced aggregation and dopaminergic cell death in cathepsin D overexpression and ZKSCAN3 knockout mice Open
α-synuclein accumulation is recognized as a prominent feature in the majority of Parkinson’s disease cases and also occurs in a broad range of neurodegenerative disorders including Alzheimer’s disease. It has been shown that α-synuclein ca…
View article: Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma
Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma Open
Small extracellular vesicles (sEVs) are known to orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is unknown. Myeloid-derived regulatory cells (MDRCs) are kno…
View article: The interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics
The interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics Open
View article: β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice
β-hydroxybutyrate administered at reperfusion reduces infarct size and preserves cardiac function by improving mitochondrial function through autophagy in male mice Open
View article: Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment
Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment Open
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification,…
View article: Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo
Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo Open
The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality control. Cathepsin D (CTSD), is one such lysosomal protease, which when deficient in humans…
View article: Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells
Metabolic adaptation to tyrosine kinase inhibition in leukemia stem cells Open
Tyrosine kinase inhibitors (TKIs) are very effective in treating chronic myelogenous leukemia (CML), but primitive, quiescent leukemia stem cells persist as a barrier to the cure. We performed a comprehensive evaluation of metabolic adapta…
View article: Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plastici…
View article: Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
Supplementary Figures and Table
View article: Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
Supplementary Figures and Table
View article: Relationships between gene expression and behavior in mice in response to systemic modulation of the <scp>O‐GlcNAcylation</scp> pathway
Relationships between gene expression and behavior in mice in response to systemic modulation of the <span>O‐GlcNAcylation</span> pathway Open
Enhancing protein O‐GlcNAcylation by pharmacological inhibition of the enzyme O‐GlcNAcase (OGA), which removes the O‐GlcNAc modification from proteins, has been explored in mouse models of amyloid‐beta and tau pathology. However, the O‐Glc…
View article: Cardiomyocyte <scp>ZKSCAN3</scp> regulates remodeling following pressure‐overload
Cardiomyocyte <span>ZKSCAN3</span> regulates remodeling following pressure‐overload Open
Autophagy is important for protein and organelle quality control. Growing evidence demonstrates that autophagy is tightly controlled by transcriptional mechanisms, including repression by zinc finger containing KRAB and SCAN domains 3 (ZKS…
View article: Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plastici…
View article: Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
Supplementary Figures and Table
View article: Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Supplementary Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
Supplementary Figures and Table
View article: Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Data from Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plastici…
View article: Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer
Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer Open
The tumor immune microenvironment dynamically evolves to support tumor growth and progression. Immunosuppressive regulatory T cells (Treg) promote tumor growth and metastatic seeding in patients with breast cancer. Deregulation of plastici…
View article: Supplementary Figure 5 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Supplementary Figure 5 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages Open
Supplementary Figure 5
View article: Supplementary Figure 2 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Supplementary Figure 2 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages Open
Supplementary Figure 2
View article: Supplementary Figure 7 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Supplementary Figure 7 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages Open
Supplementary Figure 7
View article: Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma Open
Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly a century ago, effective therapeutic targeting of glycolysis in can…
View article: Supplementary Figure 5 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages
Supplementary Figure 5 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages Open
Supplementary Figure 5
View article: Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma Open
A description of additional supplemental methods