Ute Jungwirth
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View article: YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma
YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma Open
Summary Squamous cell carcinoma cells experience high levels of replication stress due to oncogene-induced cell cycle deregulation. How such cells sustain rapid proliferation despite replication stress is still not fully understood. Here, …
View article: Synergistic Interface Platforms: Designing Superhydrophilic Conductive Nanoparticle‐Decorated Nanofibrous Membranes
Synergistic Interface Platforms: Designing Superhydrophilic Conductive Nanoparticle‐Decorated Nanofibrous Membranes Open
In today's technological landscape, advancing methods for producing conductive membranes that simplify and streamline the development of advanced interface materials is crucial. This study introduces a versatile and innovative method for f…
View article: Generation of 3D Fibroblast-Derived Extracellular Matrix and Analysis of Tumor Cell-Matrix Interactions and Signaling
Generation of 3D Fibroblast-Derived Extracellular Matrix and Analysis of Tumor Cell-Matrix Interactions and Signaling Open
Fibroblasts are the major producers of the extracellular matrix and regulate its organization. Aberrant signaling in diseases such as fibrosis and cancer can impact the deposition of the matrix proteins, which can in turn act as an adhesio…
View article: Ectopic expression of HNF4α in Het1A cells induces an invasive phenotype
Ectopic expression of HNF4α in Het1A cells induces an invasive phenotype Open
Barrett's oesophagus (BO) is a pathological condition in which the squamous epithelium of the distal oesophagus is replaced by an intestinal-like columnar epithelium originating from the gastric cardia. Several somatic mutations contribute…
View article: 3D‐Printed Hollow Microneedle‐Lateral Flow Devices for Rapid Blood‐Free Detection of C‐Reactive Protein and Procalcitonin
3D‐Printed Hollow Microneedle‐Lateral Flow Devices for Rapid Blood‐Free Detection of C‐Reactive Protein and Procalcitonin Open
Hollow microneedle devices as a technology for interstitial fluid extraction show promise for the minimally invasive point‐of‐care detection of analytes. Despite increasing efforts toward on‐patch diagnostics, the use of hollow microneedle…
View article: Supplementary Table 1; Figures 1-4 from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Supplementary Table 1; Figures 1-4 from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair Open
PDF File - 512K, Solid cancer cell lines and their genetic characteristics.
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Figure 1. Role of p53 status and mitochondrial membrane depolarization in KP46-induced cell death Supplementary Figure 2. Expression and localization changes of pro- and anti-apoptotic Bcl-2 family members in response to KP46…
View article: Data from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Data from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair Open
Arsenic trioxide (ATO), one of the oldest remedies used in traditional medicine, was recently rediscovered as an anticancer drug and approved for treatment of relapsed acute promyelocytic leukemia. However, its activity against nonhematolo…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Figure 1. Role of p53 status and mitochondrial membrane depolarization in KP46-induced cell death Supplementary Figure 2. Expression and localization changes of pro- and anti-apoptotic Bcl-2 family members in response to KP46…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Video 1. Impact of calpain inhibition on the dynamics of KP64-induced rapid cell death of A427 cells
View article: Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
On the basis of enhanced tumor accumulation and bone affinity, gallium compounds are under development as anticancer and antimetastatic agents. In this study, we analyzed molecular targets of one of the lead anticancer gallium complexes [K…
View article: Data from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Data from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair Open
Arsenic trioxide (ATO), one of the oldest remedies used in traditional medicine, was recently rediscovered as an anticancer drug and approved for treatment of relapsed acute promyelocytic leukemia. However, its activity against nonhematolo…
View article: Supplementary Table 1; Figures 1-4 from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Supplementary Table 1; Figures 1-4 from Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair Open
PDF File - 512K, Solid cancer cell lines and their genetic characteristics.
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Video 1. Impact of calpain inhibition on the dynamics of KP64-induced rapid cell death of A427 cells
View article: Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
On the basis of enhanced tumor accumulation and bone affinity, gallium compounds are under development as anticancer and antimetastatic agents. In this study, we analyzed molecular targets of one of the lead anticancer gallium complexes [K…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Legends to all supplementary figures and the video
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Legends to all supplementary figures and the video
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Data from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Data from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Immune-checkpoint blockade (ICB) promotes antitumor immune responses and can result in durable patient benefit. However, response rates in breast cancer patients remain modest, stimulating efforts to discover novel treatment options. Cance…
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Data from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Data from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Immune-checkpoint blockade (ICB) promotes antitumor immune responses and can result in durable patient benefit. However, response rates in breast cancer patients remain modest, stimulating efforts to discover novel treatment options. Cance…
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Table from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
View article: Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade Open
Supplementary Figure from Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade