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View article: Molecular mechanism of co-transcriptional H3K36 methylation by SETD2
Molecular mechanism of co-transcriptional H3K36 methylation by SETD2 Open
H3K36me3 is a hallmark of actively and recently transcribed genes and contributes to cellular memory and identity. The deposition of H3K36me3 occurs co-transcriptionally when the methyltransferase SETD2 associates with RNA polymerase II. H…
View article: IWS1 positions downstream DNA to globally stimulate Pol II elongation
IWS1 positions downstream DNA to globally stimulate Pol II elongation Open
The protein IWS1 (Interacts with SPT6 1) is implicated in transcription-associated processes, but a direct role in RNA polymerase (Pol) II function is unknown. Here, we use multi-omics kinetic analysis after rapid depletion of IWS1 in huma…
View article: FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo
FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo Open
Facilitates chromatin transcription (FACT) is a histone chaperone that supports transcription through chromatin in vitro, but its functional roles in vivo remain unclear. Here, we analyze the in vivo functions of FACT with the use of multi…