Uthayakumar Muthukumarasamy
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View article: High-resolution taxonomic profiling and metatranscriptomics identify microbial, biochemical, host and ecological factors in peri-implant disease
High-resolution taxonomic profiling and metatranscriptomics identify microbial, biochemical, host and ecological factors in peri-implant disease Open
Biofilm-associated diseases like peri-implant mucositis (PIM) and peri-implantitis (PI) are significant clinical challenges affecting millions of dental implant patients globally. Although studies have described the role of microbial, host…
View article: Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner
Klebsiella oxytoca facilitates microbiome recovery via antibiotic degradation and restores colonization resistance in a diet-dependent manner Open
Competition among bacteria for carbohydrates is pivotal for colonization resistance (CR). However, the impact of Western-style diets on CR remains unclear. Here we show how the competition between Klebsiella oxytoca and Klebsiella pneumoni…
View article: High Abundance of Gut Bacteroides in Early Childhood correlates with Microbiome Stability and Resilience after Antibiotic Treatment and with Increased Risk for Childhood Infections
High Abundance of Gut Bacteroides in Early Childhood correlates with Microbiome Stability and Resilience after Antibiotic Treatment and with Increased Risk for Childhood Infections Open
Background Early childhood events, up to the age of two, are critical for the development of the microbiome and balanced immunity later in life. We investigated whether susceptibility to infections and microbiome resilience after antibioti…
View article: Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms
Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms Open
View article: An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between <i>Klebsiella</i> species
An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between <i>Klebsiella</i> species Open
Cas9-based gene editing tools have revolutionized genetics, enabling the fast and precise manipulation of diverse bacterial species. However, widely applicable genetic tools for non-model gut bacteria are unavailable. Here, we present a tw…
View article: An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between<i>Klebsiella</i>species
An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between<i>Klebsiella</i>species Open
Cas9-based gene editing tools have revolutionized genetics, enabling the fast and precise manipulation of diverse bacterial species. However, widely applicable genetic tools for non-model gut bacteria are unavailable. Here, we present a tw…
View article: Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice Open
View article: Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis
Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis Open
View article: Additional file 3 of Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice
Additional file 3 of Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice Open
Additional file 3.
View article: Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection
Microbiota of vaccinated and non-vaccinated clinically inconspicuous and conspicuous piglets under natural Lawsonia intracellularis infection Open
Lawsonia ( L .) intracellularis is a widespread, economically important bacterium causing the porcine proliferative enteropathy (PPE). In this study, we evaluated intestinal microbiota of naturally exposed L. intracellularis -positive pigs…
View article: High Dietary Intake of Rye Affects Porcine Gut Microbiota in a Salmonella Typhimurium Infection Study
High Dietary Intake of Rye Affects Porcine Gut Microbiota in a Salmonella Typhimurium Infection Study Open
Bacterial fermentation of undigested carbohydrates in the hindgut has considerable potential for the stimulation or inhibition of the growth of distinct bacteria within microbiota. The aim of the present study was to evaluate whether high …
View article: Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment Open
View article: Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study
Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study Open
View article: Single-Nucleotide Polymorphism-Based Genetic Diversity Analysis of Clinical Pseudomonas aeruginosa Isolates
Single-Nucleotide Polymorphism-Based Genetic Diversity Analysis of Clinical Pseudomonas aeruginosa Isolates Open
Extensive use of next-generation sequencing has the potential to transform our knowledge on how genomic variation within bacterial species impacts phenotypic versatility. Because different environments have unique selection pressures, they…
View article: The genomic and transcriptomic landscape of clinical Escherichia coli and Pseudomonas aeruginosa isolates
The genomic and transcriptomic landscape of clinical Escherichia coli and Pseudomonas aeruginosa isolates Open
Large amounts of genomic data have been obtained due to the rapid advances in DNA sequencing technology. With efficient computational platforms, these data can provide many possibilities to improve our knowledge on species evolution and th…
View article: BACTOME—a reference database to explore the sequence- and gene expression-variation landscape of<i>Pseudomonas aeruginosa</i>clinical isolates
BACTOME—a reference database to explore the sequence- and gene expression-variation landscape of<i>Pseudomonas aeruginosa</i>clinical isolates Open
Extensive use of next-generation sequencing (NGS) for pathogen profiling has the potential to transform our understanding of how genomic plasticity contributes to phenotypic versatility. However, the storage of large amounts of NGS data an…
View article: Deep transcriptome profiling of clinical <scp> <i>K</i> </scp> <i>lebsiella pneumoniae</i> isolates reveals strain and sequence type‐specific adaptation
Deep transcriptome profiling of clinical <span> <i>K</i> </span> <i>lebsiella pneumoniae</i> isolates reveals strain and sequence type‐specific adaptation Open
Summary Health‐care‐associated infections by multi‐drug‐resistant bacteria constitute one of the greatest challenges to modern medicine. Bacterial pathogens devise various mechanisms to withstand the activity of a wide range of antimicrobi…