Utpal Nandi
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View article: Crocetin Impairs the Cytochrome P450 Epoxygenase Pathway toward Potentiating the Therapeutic Efficacy of Paclitaxel in Metastatic Breast Cancer
Crocetin Impairs the Cytochrome P450 Epoxygenase Pathway toward Potentiating the Therapeutic Efficacy of Paclitaxel in Metastatic Breast Cancer Open
Triple-negative breast cancer (TNBC) is the most fatal subtype of breast cancer owing to its aggressive nature and limited treatment strategies. Despite significant advancements in cancer research, targeted therapeutic interventions to mit…
View article: Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta
Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta Open
AD pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and help ameliorate AD pathology. We discove…
View article: Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice Open
Background and Aim Alzheimer’s disease (AD) progresses with Aβ plaque deposition and neuroinflammation. Given the complexity of AD pathology, single-target therapies have frequently failed in clinical trials. We hypothesized that a multita…
View article: Silicon incorporated tacrine: design, synthesis, and evaluation of biological and pharmacokinetic parameters
Silicon incorporated tacrine: design, synthesis, and evaluation of biological and pharmacokinetic parameters Open
We report a silicon-incorporated tacrine and assess its cholinesterase inhibitory activity, in vitro metabolic stability, and brain/plasma pharmacokinetic profile.
View article: Discovery and biological evaluation of nitrofuranyl–pyrazolopyrimidine hybrid conjugates as potent antimicrobial agents targeting <i>Staphylococcus aureus</i> and methicillin-resistant <i>S. aureus</i>
Discovery and biological evaluation of nitrofuranyl–pyrazolopyrimidine hybrid conjugates as potent antimicrobial agents targeting <i>Staphylococcus aureus</i> and methicillin-resistant <i>S. aureus</i> Open
Nitrofuranyl–pyrazolopyrimidine conjugates exhibiting potent in vitro and in vivo efficacy against Gram-positive bacterial strain S. aureus and its resistant variant methicillin-resistant S. aureus .
View article: Ensemble Transfer Learning for Image Classification
Ensemble Transfer Learning for Image Classification Open
The deep learning (DL) techniques used for image classification might not deliver the desired level of classification accuracy as some features belonging to some class of a dataset are missed during feature extraction. The ensemble learnin…
View article: Out-of-pocket payment and catastrophic health expenditure of tuberculosis patients in accessing care at public-private mix clinics in Myanmar, 2022
Out-of-pocket payment and catastrophic health expenditure of tuberculosis patients in accessing care at public-private mix clinics in Myanmar, 2022 Open
View article: Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation
Discovery of Ring-Annulated Analogues of Cannabidiol as Potential Anticancer Agents: Synthesis and Biological Evaluation Open
Cannabidiol (CBD) is a nonpsychoactive cannabinoid derived from Cannabis sativa and its potential therapeutic effects extend beyond its well-known antiepileptic properties. Exploring CBD and its analogues as anticancer agents has ga…
View article: Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice
Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice Open
Aging is usually accompanied by mitochondrial dysfunction, reduced energy levels, and cell death in the brain and other tissues. Mitochondria play a crucial role in maintaining cellular energy through oxidative phosphorylation (OXPHOS). Ho…
View article: Out-of-pocket payment and catastrophic health expenditure of Tuberculosis (TB)patients in accessing care at (public-private mix) PPM clinics in Myanmar (2022)
Out-of-pocket payment and catastrophic health expenditure of Tuberculosis (TB)patients in accessing care at (public-private mix) PPM clinics in Myanmar (2022) Open
Background The financial burden of tuberculosis (TB) can hinder patients and their families, creating obstacles throughout the care cascade, despite TB prevention and control being provided free of charge. The study focused on quantifying …
View article: ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features
ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features Open
Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The chemical structure of crocetin is incongruent with various standard structural features of CNS drugs. As poor pharmacokinetic behavior is the major hurdle …
View article: Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter
Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter Open
JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it only regulates a narrow spectru…
View article: EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir
EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir Open
EIDD-1931 is the active form of molnupiravir, an orally effective drug approved by the United States Food and Drug Administration (USFDA) against COVID-19. Pharmacokinetic alteration can cause untoward drug interaction (drug-drug/disease-d…
View article: Development of Mupirocin-Impregnated Bacterial Cellulosic Transdermal Patches for the Management of Skin Infection
Development of Mupirocin-Impregnated Bacterial Cellulosic Transdermal Patches for the Management of Skin Infection Open
[Image: see text] The present study reports the production of bacterial cellulose (BC) membranes using Komagataeibacter hansenii for the development of transdermal wound healing patches. BC-based transdermal patches were developed by impre…
View article: Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation
Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation Open
Cannabidiol (CBD 1) is a nonpsychotic cannabinoid-based drug approved by the U.S. FDA for treating refractory epilepsy, namely, Lennox-Gastaut and Dravet syndrome. However, its low aqueous solubility and oral bioavailability are com…
View article: Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes
Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes Open
Being present in substantial numbers, astrocytes play an indispensable role in maintaining homeostasis in the brain. However, their positive or negative involvement in pathological conditions in the brain has not been explored much. In rec…
View article: Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation
Development of di-arylated 1,2,4-triazole-based derivatives as therapeutic agents against breast cancer: synthesis and biological evaluation Open
The most potent derivative (4q, IC 50 = 4.8 μM) of the newly synthesized diarylated 1,2,4-triazole series displays several hallmarks of apoptosis in the MCF-7 breast cancer cells and favourable metabolic stability in diverse liver microsom…
View article: Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD mice
Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD mice Open
The complex pathology of Alzheimer disease (AD) has led to failure of multiple drugs in clinical trials. We hypothesized that targeting multiple aspects AD pathology may yield better results. Therefore, we identified isobavachalcone (IBC) …
View article: Sila-CBD Derivatives as Inhibitors of Heme-Induced NLRP3 Inflammasome: Application in Hemolytic Diseases
Sila-CBD Derivatives as Inhibitors of Heme-Induced NLRP3 Inflammasome: Application in Hemolytic Diseases Open
Synthesis and biological evaluation of silicon-incorporated phytocannabinoids with improved pharmacological properties toward inflammatory diseases are described. The synthesized sila-analogues 15a, 15b, and 15c displa…
View article: Crocetin delays brain and body aging by increasing cellular energy levels and enhances the median life span in aged C57BL/6J mice
Crocetin delays brain and body aging by increasing cellular energy levels and enhances the median life span in aged C57BL/6J mice Open
Background and Purpose Aging is usually accompanied by mitochondrial dysfunction, reduced energy levels, and cell death in the brain and other tissues. Mitochondria play a crucial role in maintaining cellular energy through oxidative phosp…
View article: Orally bioavailable styryl derivative of rohitukine-N-oxide inhibits CDK9/T1 and the growth of pancreatic cancer cells
Orally bioavailable styryl derivative of rohitukine-N-oxide inhibits CDK9/T1 and the growth of pancreatic cancer cells Open
View article: Ellagic Acid Exerts Dual Action to Curb the Pathophysiological Manifestations of Sickle Cell Disease and Attenuate the Hydroxyurea-Induced Myelosuppression in Berkeley Mice
Ellagic Acid Exerts Dual Action to Curb the Pathophysiological Manifestations of Sickle Cell Disease and Attenuate the Hydroxyurea-Induced Myelosuppression in Berkeley Mice Open
The use of adjuvant therapy is an attractive approach to manage sickle cell disease (SCD) symptomatically. The present study aimed to investigate the potential of ellagic acid as an adjuvant therapy with hydroxyurea (HU), a key drug for SC…
View article: Identification of New Modulator of DNA Repairing Pathways Based on Natural Product (±)-Peharmaline a
Identification of New Modulator of DNA Repairing Pathways Based on Natural Product (±)-Peharmaline a Open
View article: Recent Researches on Image Classification Using Deep Learning Approach
Recent Researches on Image Classification Using Deep Learning Approach Open
View article: Glabridin Plays Dual Action to Augment the Efficacy and Attenuate the Hepatotoxicity of Methotrexate in Arthritic Rats
Glabridin Plays Dual Action to Augment the Efficacy and Attenuate the Hepatotoxicity of Methotrexate in Arthritic Rats Open
Glabridin is chemically an isoflavane class of natural phenols and is found mainly in the roots of Glycyrrhiza glabra. It has several beneficial pharmacological actions for the management of inflammatory disorders as well as can cou…
View article: Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Approaches
Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Approaches Open
Pinocembrin, a bioflavonoid, is extensively used in complementary/alternative medicine. It turns out as a promising candidate against neurodegenerative diseases because of its multifaceted pharmacological action toward neuroprotection. How…
View article: Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP
Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP Open
Diclofenac is a widely prescribed anti-inflammatory drug having cardiovascular complications as one of the main liabilities that restrict its therapeutic use. We aimed to investigate for any role of rutin against diclofenac-induced cardiac…
View article: Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmacetical drug as a potential for the treatment of dengue and COVID-19
Clinical safety and pharmacokinetic evaluation of aqueous extract of Cocculus hirsutus, an anti-viral phytopharmacetical drug as a potential for the treatment of dengue and COVID-19 Open
View article: 2-Pyridin-4-yl-methylene-beta-boswellic Acid─A Potential Candidate for Targeting O<sup>6</sup>-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D─Microsatellite Stable, G12V─Microsatellite Instable Mutant Colon Cancer
2-Pyridin-4-yl-methylene-beta-boswellic Acid─A Potential Candidate for Targeting O<sup>6</sup>-Methylguanine-DNA Methyltransferase Epi-transcriptional Reprogramming in KRAS G13D─Microsatellite Stable, G12V─Microsatellite Instable Mutant Colon Cancer Open
PMBA (2-Pyridin-4-yl-methylene-beta-boswellic acid), screened from among the 21 novel series of semisynthetic analogues of β-boswellic acid, is being presented as a lead compound for integrative management of KRAS mutant colorectal cancer …
View article: Investigating the Potential Use of Andrographolide as a Coadjuvant in Sickle Cell Anemia Therapy
Investigating the Potential Use of Andrographolide as a Coadjuvant in Sickle Cell Anemia Therapy Open
Andrographolide is one of the main active principles of Andrographolide paniculata and has been extensively explored for its therapeutic use. Current studies focus on phytotherapeutics-based adjuvant therapy to symptomatically treat…