Uttara Basu
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View article: Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold(<scp>i</scp>) alkynyl complex
Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold(<span>i</span>) alkynyl complex Open
An organometallic anticancer drug candidate with a mechanism related to TrxR inhibition and mitochondrial respiration inhibition shows efficient in vivo antitumor efficacy.
View article: Multitarget Thiol-Activated Tetrapyridyl Gold(III) Complexes for Hypoxic Cancer Therapy
Multitarget Thiol-Activated Tetrapyridyl Gold(III) Complexes for Hypoxic Cancer Therapy Open
Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase (TrxR) inhibition, which disturbs the redox balance of cancer cells.However, in this model, the role of the ligand(s) coordinated…
View article: CCDC 2253347: Experimental Crystal Structure Determination
CCDC 2253347: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253350: Experimental Crystal Structure Determination
CCDC 2253350: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253353: Experimental Crystal Structure Determination
CCDC 2253353: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253349: Experimental Crystal Structure Determination
CCDC 2253349: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253352: Experimental Crystal Structure Determination
CCDC 2253352: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253351: Experimental Crystal Structure Determination
CCDC 2253351: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2253348: Experimental Crystal Structure Determination
CCDC 2253348: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance”
Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance” Open
[This corrects the article DOI: 10.1021/acscentsci.3c00286.].
View article: New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance
New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance Open
Tumor cells adapt to diverse survival strategies defying our pursuit of multimodal cancer therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent chemotherapeutics, cisplatin. PCa cells survive and prolifer…
View article: Oral Anticancer Heterobimetallic Pt<sup>IV</sup>−Au<sup>I</sup>Complexes Show High In Vivo Activity and Low Toxicity
Oral Anticancer Heterobimetallic Pt<sup>IV</sup>−Au<sup>I</sup>Complexes Show High In Vivo Activity and Low Toxicity Open
Au I ‐carbene and Pt IV −Au I ‐carbene prodrugs display low to sub‐μM activity against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt‐derived Pt IV (phenylbutyrate) complex to a Au I ‐phenylimidazolyli…
View article: Oral Anticancer Heterobimetallic Pt<sup>IV</sup>−Au<sup>I</sup>Complexes Show High In Vivo Activity and Low Toxicity
Oral Anticancer Heterobimetallic Pt<sup>IV</sup>−Au<sup>I</sup>Complexes Show High In Vivo Activity and Low Toxicity Open
Au I ‐carbene and Pt IV −Au I ‐carbene prodrugs display low to sub‐μM activity against several cancer cell lines and overcome cisplatin (cisPt) resistance. Linking a cisPt‐derived Pt IV (phenylbutyrate) complex to a Au I ‐phenylimidazolyli…
View article: Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL<sup>pro</sup>
Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL<sup>pro</sup> Open
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for…
View article: [(C C)Au(N N)]<sup>+</sup> Complexes as a New Family of Anticancer Candidates: Synthesis, Characterization and Exploration of the Antiproliferative Properties
[(C C)Au(N N)]<sup>+</sup> Complexes as a New Family of Anticancer Candidates: Synthesis, Characterization and Exploration of the Antiproliferative Properties Open
A library of eleven cationic gold(III) complexes of the general formula [(C C)Au(N N)] + when C C is either biphenyl or 4,4’‐ditertbutyldiphenyl and N N is a bipyridine, phenanthroline or dipyridylamine derivative have been synthesized and…
View article: Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity
Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity Open
In this work, a pair of gold(III) complexes derived from the analogous tetrapyridyl ligands H2biqbpy1 and H2biqbpy2 was prepared: the rollover, bis-cyclometalated [Au(biqbpy1)Cl ([1]Cl) and its isomer [Au(biqbpy2)Cl ([2]Cl). In [1]+, two p…
View article: CCDC 1989681: Experimental Crystal Structure Determination
CCDC 1989681: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1989679: Experimental Crystal Structure Determination
CCDC 1989679: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1989680: Experimental Crystal Structure Determination
CCDC 1989680: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Discovery and Supramolecular Interactions of Neutral Palladium‐Oxo Clusters Pd<sub>16</sub>and Pd<sub>24</sub>
Discovery and Supramolecular Interactions of Neutral Palladium‐Oxo Clusters Pd<sub>16</sub>and Pd<sub>24</sub> Open
We report on the synthesis, structure, and physicochemical characterization of the first three examples of neutral palladium‐oxo clusters (POCs). The 16‐palladium(II)‐oxo cluster [Pd 16 O 24 (OH) 8 ((CH 3 ) 2 As) 8 ] ( Pd 16 ) comprises a …
View article: Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics**
Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike‐ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics** Open
Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti‐infective effects have been confirmed. Herein, we evaluated the lead compound Auranofin and five selected gold organometallics as inhi…
View article: Gold Metallodrugs to Fight the Corona Virus: Inhibitory Effects on the SpikeACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics
Gold Metallodrugs to Fight the Corona Virus: Inhibitory Effects on the SpikeACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics Open
Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti-infective effects have been confirmed. Here we evaluated the lead compound Auranofin and five selected gold organometallics as inhibit…
View article: Gold Metallodrugs to Fight the Corona Virus: Inhibitory Effects on the SpikeACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics
Gold Metallodrugs to Fight the Corona Virus: Inhibitory Effects on the SpikeACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics Open
Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti-infective effects have been confirmed. Here we evaluated the lead compound Auranofin and five selected gold organometallics as inhibit…