Uwe Siebert
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View article: Disease Management Program for the Care of Hypertensive Patients Using Telemedical Support
Disease Management Program for the Care of Hypertensive Patients Using Telemedical Support Open
Background Hypertension (HTN) is the leading global risk factor for premature death and disability. In Austria, as in many countries, treatment and blood pressure (BP) control rates are suboptimal. Previous studies have revealed low target…
View article: Systematic review on community-based interventions targeting prevention of overweight and obesity in children and adolescents
Systematic review on community-based interventions targeting prevention of overweight and obesity in children and adolescents Open
Background With increasing obesity rates, community-based interventions (CBIs) have gained attention as more evidence suggests that the environment has a significant impact on individuals’ behaviors. We aimed to conduct a systematic review…
View article: General population preferences for health-related protective behaviors during infectious disease emergencies: a systematic review of conjoint-analysis studies
General population preferences for health-related protective behaviors during infectious disease emergencies: a systematic review of conjoint-analysis studies Open
This review demonstrates the complexity of public preferences for protective measures and highlights the importance of aligning public health strategies with individual preferences by taking into account substantial heterogeneity. Incorpor…
View article: Comparative effectiveness of take-home dosing schedules for opioid agonist treatment in British Columbia, Canada: a target trial emulation protocol using a population-based observational study
Comparative effectiveness of take-home dosing schedules for opioid agonist treatment in British Columbia, Canada: a target trial emulation protocol using a population-based observational study Open
Introduction The introduction of fentanyl and its analogues in the illicit drug supply has prompted greater emphasis on refining clinical treatment protocols to ensure sustained retention in opioid agonist treatment (OAT). Take-home dosing…
View article: Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project
Recommended methodologies for clinical investigations of high-risk medical devices—Conclusions from the European Union CORE–MD Project Open
The CORE-MD project was funded as a Coordination and Support action from the European UnionHorizon 2020 research and innovation programme, under grant agreement 965246.
View article: Finding the right tool for the specific task: navigating RWE tools and checklists
Finding the right tool for the specific task: navigating RWE tools and checklists Open
Real-world evidence (RWE) is increasingly used to support product approvals and label expansions, as well as clinical and payer decision-making. Various tools (e.g. frameworks, checklists) have been developed to help inform and assess the …
View article: Comparative effectiveness of alternative initial doses of opioid agonist treatment for individuals with opioid use disorder: a protocol for a retrospective population-based study using target trial emulation in British Columbia, Canada
Comparative effectiveness of alternative initial doses of opioid agonist treatment for individuals with opioid use disorder: a protocol for a retrospective population-based study using target trial emulation in British Columbia, Canada Open
Introduction Selecting an optimal initial dosage of opioid agonist treatment (OAT) balances effectiveness and safety, as initial doses that are too low may be insufficient, potentially prompting clients to seek unregulated drugs to allevia…
View article: Comparative effectiveness of urine drug testing schedules alongside opioid agonist treatment: Emulation of a population‐based target trial in British Columbia, Canada
Comparative effectiveness of urine drug testing schedules alongside opioid agonist treatment: Emulation of a population‐based target trial in British Columbia, Canada Open
Background and aim Urine drug testing is often utilized alongside opioid agonist treatment to assess client progress by validating self‐reported substance use, monitoring for diversion and supporting clinical decisions for take‐home dosing…
View article: Quality of diabetes mellitus healthcare and metabolic control during transition from paediatric to adult care: A systematic review and meta‐analysis
Quality of diabetes mellitus healthcare and metabolic control during transition from paediatric to adult care: A systematic review and meta‐analysis Open
Aims Emerging adults with chronic diseases like diabetes often experience a decline in health during the process of transition from paediatric to adult healthcare. This study assesses the impact of transition on healthcare quality of peopl…
View article: Sudden cardiac death in newly diagnosed non-ischaemic or ischaemic cardiomyopathy assessed with a wearable cardioverter-defibrillator: the German nationwide SCD-PROTECT study
Sudden cardiac death in newly diagnosed non-ischaemic or ischaemic cardiomyopathy assessed with a wearable cardioverter-defibrillator: the German nationwide SCD-PROTECT study Open
Background and Aims Patients with newly diagnosed non-ischaemic cardiomyopathy (NICM) or myocardial infarction/coronary artery disease (MI/CAD) face an increased risk of sudden cardiac death (SCD) during the early phase of guideline-recomm…
View article: Life Expectancy Predicted by Decision-Analytic Models Evaluating Screening for Prostate, Lung, Breast, and Colorectal Cancer: A Systematic Review Focusing on Competing Mortality Risks
Life Expectancy Predicted by Decision-Analytic Models Evaluating Screening for Prostate, Lung, Breast, and Colorectal Cancer: A Systematic Review Focusing on Competing Mortality Risks Open
Background It is still a matter of debate whether a reduction in cancer-specific mortality due to cancer screening fully translates into a reduction in all-cause mortality and thus into a gain in life expectancy. Nevertheless, decision-ana…
View article: Effective sample size for the Kaplan-Meier estimator: A valuable measure of uncertainty?
Effective sample size for the Kaplan-Meier estimator: A valuable measure of uncertainty? Open
View article: Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial
Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial Open
Vertebral fractures (VFs) are among the most common osteoporotic fractures. The effect of vitamin D3, omega-3s or a simple home exercise program (SHEP) on VFs is unclear. We examined whether vitamin D3, omega-3s, or SHEP, alone or in combi…
View article: MeDeMSA care study protocol: developing personalized best medical care with integrated mobile palliative and telemedicine support for individuals with multiple system atrophy
MeDeMSA care study protocol: developing personalized best medical care with integrated mobile palliative and telemedicine support for individuals with multiple system atrophy Open
Multiple system atrophy (MSA) represents a management challenge due to its variable clinical presentation, and lack of established multidisciplinary care protocols. In advanced stages, physical barriers often prevent access to specialized …
View article: Mammography screening and risk factor prevalence by sexual identity: A comparison of two national surveys
Mammography screening and risk factor prevalence by sexual identity: A comparison of two national surveys Open
Background Emerging research suggests that lesbian, gay, bisexual, and queer (LGBQ) women face barriers to breast cancer screening. The authors sought to quantify sexual identity disparities in mammography screening, health care access, an…
View article: The Use of EQ-5D in the Middle East and North Africa Region: A Systematic Literature Review
The Use of EQ-5D in the Middle East and North Africa Region: A Systematic Literature Review Open
View article: Influence of prior knowledge and experience on willingness to pay for home hospice services: a contingent valuation study
Influence of prior knowledge and experience on willingness to pay for home hospice services: a contingent valuation study Open
View article: Sex-Specific Fall Trajectories and Associated Self-Reported Risk Factors: A Prospective Analysis of the 3-Year 5-Country DO-HEALTH Trial
Sex-Specific Fall Trajectories and Associated Self-Reported Risk Factors: A Prospective Analysis of the 3-Year 5-Country DO-HEALTH Trial Open
This study provides a comprehensive assessment of falls over 3 years, highlighting differences in fall patterns and associated self-reported risk factors between men and women. These findings may offer valuable insights for developing sex-…
View article: One in three adenomas could be missed by white-light colonoscopy – findings from a systematic review and meta-analysis
One in three adenomas could be missed by white-light colonoscopy – findings from a systematic review and meta-analysis Open
View article: Directed Acyclic Graphs in Decision-Analytic Modeling: Bridging Causal Inference and Effective Model Design in Medical Decision Making
Directed Acyclic Graphs in Decision-Analytic Modeling: Bridging Causal Inference and Effective Model Design in Medical Decision Making Open
Decision-analytic models (DAMs) are essentially informative yet complex tools for solving questions in medical decision making. When their complexity grows, the need for causal inference techniques becomes evident as causal relationships b…
View article: Systematic Literature Review of Decision‐Analytic Modeling Studies on Nature‐Based Social Prescribing and Loneliness
Systematic Literature Review of Decision‐Analytic Modeling Studies on Nature‐Based Social Prescribing and Loneliness Open
Nature‐based social prescribing (NBSP) is an evolving subject aiming to reduce loneliness and to foster social connections, health, and well‐being. To evaluate the short‐term and long‐term consequences of different health technologies, dec…
View article: Epidemiology and Economic Burden of Sleep Disorders in Europe
Epidemiology and Economic Burden of Sleep Disorders in Europe Open
View article: A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections
A unified framework for diagnostic test development and evaluation during outbreaks of emerging infections Open
View article: PP60 Enhancing Patient Empowerment: European Capacity Building Initiative And Curriculum Development In Health Technology Assessment Training
PP60 Enhancing Patient Empowerment: European Capacity Building Initiative And Curriculum Development In Health Technology Assessment Training Open
Introduction The new Regulation (EU) 2021/2282 on health technology assessment (HTAR) highlights the increasing importance of patient perspectives, emphasizing their crucial role in HTA. The European Capacity Building for Patients (EUCAPA)…
View article: OP76 Cost-Effectiveness Of Offering Human Papillomavirus Self-Sampling To Non-Attendees Of Organized Primary Cervical Cancer Screening In Germany
OP76 Cost-Effectiveness Of Offering Human Papillomavirus Self-Sampling To Non-Attendees Of Organized Primary Cervical Cancer Screening In Germany Open
Introduction In Germany, organized cervical cancer screening with annual Papanicolaou (Pap) cytology for women age 20 to 34 years and three-yearly co-testing with human papillomavirus (HPV) and Pap for women as of age 35 years is standard.…
View article: PD89 Guidance For Designing Pivotal Studies Of High-Risk Medical Devices By International Regulatory Authorities: A Systematic Review
PD89 Guidance For Designing Pivotal Studies Of High-Risk Medical Devices By International Regulatory Authorities: A Systematic Review Open
Introduction Health technology assessment of medical devices often faces the challenge that approval studies have an insufficient study design. The European Medical Device Regulation (MDR), which has been in force since May 2021, places st…
View article: Methodological Guidelines and Publications of Benefitrisk Assessment for Health Technology Assessment: A Scoping Review
Methodological Guidelines and Publications of Benefitrisk Assessment for Health Technology Assessment: A Scoping Review Open
Introduction Benefit-risk assessment (BRA) is an important component in decision-making throughout the lifecycle of a health technology. The BRA of comparative technologies was usually carried out informally, without the use of a systemati…
View article: Herausforderungen bei der Entwicklung von Leitlinien für Maßnahmen zur Förderung und Aufrechterhaltung der öffentlichen Gesundheit
Herausforderungen bei der Entwicklung von Leitlinien für Maßnahmen zur Förderung und Aufrechterhaltung der öffentlichen Gesundheit Open
Zusammenfassung Leitlinien sind etablierte Instrumente der evidenzbasierten Medizin. Bei der Anwendung im Öffentlichen Gesundheitsdienst stellen komplexe Public Health Interventionen jedoch eine Herausforderung dar. Der Beitrag skizziert d…
View article: P248 Neoadjuvant versus adjuvant cisplatin-based chemotherapy for muscle-invasive bladder cancer: A cost-effectiveness analyis
P248 Neoadjuvant versus adjuvant cisplatin-based chemotherapy for muscle-invasive bladder cancer: A cost-effectiveness analyis Open
View article: Participants’ baseline characteristics and feedback of the nature-based social intervention “friends in nature” among lonely older adults in assisted living facilities in finland: a randomised controlled trial of the RECETAS EU-project
Participants’ baseline characteristics and feedback of the nature-based social intervention “friends in nature” among lonely older adults in assisted living facilities in finland: a randomised controlled trial of the RECETAS EU-project Open
Background Loneliness is common among older adults in institutional settings. It leads to adverse effects on health and wellbeing, for which nature contact with peers in turn may have positive impact. However, the effects of nature engagem…