Arunkumar Krishnan
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View article: Angiotensin-converting-enzyme inhibitors and risk of acute pancreatitis: a matched cohort study
Angiotensin-converting-enzyme inhibitors and risk of acute pancreatitis: a matched cohort study Open
View article: Body mass index and its association with clinical outcomes in acute liver failure
Body mass index and its association with clinical outcomes in acute liver failure Open
BACKGROUND Acute liver failure (ALF) is a life-threatening multisystemic condition with high short-term mortality. With the growing prevalence of obesity and metabolic syndrome, it is important to investigate the clinical implications of h…
View article: Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects
Postoperative immune checkpoint inhibitors plus anti-angiogenesis for hepatitis B virus-associated hepatocellular carcinoma: Analyzing the evidence and future prospects Open
A recent study by Lu et al examined the potential benefits of postoperative combined therapy (PCT) using anti-programmed cell death protein-1/PD-ligand-1 and anti-vascular endothelial growth factor agents for patients with hepatitis B viru…
View article: Prognostic value of coagulation markers in locally advanced gastric cancer following neoadjuvant immunochemotherapy
Prognostic value of coagulation markers in locally advanced gastric cancer following neoadjuvant immunochemotherapy Open
Gastric cancer (GC) has remained one of the leading causes of cancer-related deaths globally. The development of noninvasive biomarkers in cancer diagnosis and treatment has gained substantial traction in recent years. Recent evidence high…
View article: Imaging-pathology correlation in pancreatic cancer: Methodological considerations and future directions
Imaging-pathology correlation in pancreatic cancer: Methodological considerations and future directions Open
A recent study by Luo et al examined the relationship between the pathological types of pancreatic cancer (PC) and their imaging characteristics. While this study presented an important step toward improving diagnostic accuracy for PC, we …
View article: Proton pump inhibitors and all-cause mortality in colorectal cancer
Proton pump inhibitors and all-cause mortality in colorectal cancer Open
View article: Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions
Role of zinc finger protein 71 in hepatocellular carcinoma: Methodological concerns, clinical relevance, and future directions Open
A recent study by Qin et al emphasized the potential of zinc finger protein 71 (ZNF71) as a promising biomarker for hepatocellular carcinoma (HCC). The authors offered valuable insights into the relationship between ZNF71 and various clini…
View article: Macrovascular outcomes and mortality after bariatric surgery in patients with metabolic dysfunction–associated steatotic liver disease, and Type 2 diabetes
Macrovascular outcomes and mortality after bariatric surgery in patients with metabolic dysfunction–associated steatotic liver disease, and Type 2 diabetes Open
View article: Challenges in colorectal cancer post-surgical surveillance: A critical evaluation and path forward
Challenges in colorectal cancer post-surgical surveillance: A critical evaluation and path forward Open
A recent study by Sala-Miquel et al investigated the diagnostic effectiveness of follow-up strategies in patients with non-metastatic colorectal cancer (CRC) after surgical resection. This research highlighted the significance of using com…
View article: Optimizing fluoropyrimidine therapy through dihydropyrimidine dehydrogenase polymorphism testing
Optimizing fluoropyrimidine therapy through dihydropyrimidine dehydrogenase polymorphism testing Open
Fluoropyrimidines (FP), including 5-fluorouracil and its prodrug capecitabine, are commonly employed in treating various solid tumors. Nonetheless, their use is frequently constrained by severe toxicities in 20%–30% of patients. Pharmacoge…
View article: Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward
Leucine-rich alpha-2 glycoprotein for detecting small bowel lesions in Crohn’s disease: A critical review and the path forward Open
The study by Ohno et al provides valuable insights into the role of leucine-rich alpha-2-glycoprotein (LRG) as a potential biomarker for identifying small bowel lesions in Crohn's disease (CD). However, several methodological challenges hi…
View article: Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia: Methodological concerns, clinical implications, and future research directions
Endoscopic intervention in hematologic malignancy patients with severe thrombocytopenia: Methodological concerns, clinical implications, and future research directions Open
Gastrointestinal bleeding (GIB) presents a significant challenge for patients with hematologic malignancies, especially those with severe thrombocytopenia. Although endoscopic intervention is frequently used in managing GIB, its safety and…
View article: β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function
β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function Open
SUMMARY G protein-coupled receptors (GPCRs) are the largest class of receptors in the genome and control many signaling cascades essential for survival. GPCR signaling is regulated by β-arrestins, multifunctional adapter proteins that dire…
View article: Adverse Liver and Renal Outcomes After Initiating <scp>SGLT</scp>‐2i and <scp>GLP</scp>‐<scp>1RA</scp> Therapy Among Patients With Diabetes and <scp>MASLD</scp>
Adverse Liver and Renal Outcomes After Initiating <span>SGLT</span>‐2i and <span>GLP</span>‐<span>1RA</span> Therapy Among Patients With Diabetes and <span>MASLD</span> Open
Context The management of metabolic dysfunction‐associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM) presents a significant clinical challenge, with a focus on preventing progression to liver and renal complicatio…
View article: Association of cardiovascular health metrics and metabolic associated fatty liver disease: Methodological limitations, and future directions
Association of cardiovascular health metrics and metabolic associated fatty liver disease: Methodological limitations, and future directions Open
Metabolic-associated fatty liver disease (MAFLD), formerly known as nonalcoholic fatty liver disease, is an increasing global health challenge with substantial implications for metabolic and cardiovascular health (CVH). A recent study by F…
View article: Role of autoimmune phenomena in nonalcoholic fatty liver disease: Insights and limitations
Role of autoimmune phenomena in nonalcoholic fatty liver disease: Insights and limitations Open
Metabolic dysfunction-associated steatotic liver disease, previously known as nonalcoholic fatty liver disease (NAFLD), is becoming increasingly common and is associated with significant morbidity and mortality related to both liver and no…
View article: Radiomics and machine learning for predicting metachronous liver metastasis in rectal cancer
Radiomics and machine learning for predicting metachronous liver metastasis in rectal cancer Open
A recent study by Long et al used a predictive model to explore the efficacy of radiomics based on multiparametric magnetic resonance imaging in predicting metachronous liver metastasis (MLM) in newly diagnosed rectal cancer (RC) patients.…
View article: Challenges and limitations in assessing mucosal healing in Crohn’s disease: Discrepancies between endoscopic and histologic evaluations
Challenges and limitations in assessing mucosal healing in Crohn’s disease: Discrepancies between endoscopic and histologic evaluations Open
The recent study published by Lee et al examined the discrepancies between endoscopic and histologic evaluations of mucosal inflammation in active ileal Crohn’s disease (CD). While this research contributes to our understanding of the limi…
View article: Improving radiomics-based models for esophagogastric variceal bleeding risk prediction in cirrhotic patients
Improving radiomics-based models for esophagogastric variceal bleeding risk prediction in cirrhotic patients Open
A recent study by Peng et al developed a predictive model for first-instance secondary esophageal variceal bleeding in cirrhotic patients by integrating clinical and multi-organ radiomic features. The combined radiomic-clinical model demon…
View article: Radiotherapy dosage: A neural network approach for uninvolved liver dose in stereotactic body radiation therapy for liver cancer
Radiotherapy dosage: A neural network approach for uninvolved liver dose in stereotactic body radiation therapy for liver cancer Open
A recent study by Zhang et al developed a neural network-based predictive model for estimating doses to the uninvolved liver during stereotactic body radiation therapy (SBRT) in liver cancer. The study reported a significant advancement in…
View article: Improving predictive accuracy of early recurrence in pancreatic ductal adenocarcinoma: Role of postoperative serum tumor markers
Improving predictive accuracy of early recurrence in pancreatic ductal adenocarcinoma: Role of postoperative serum tumor markers Open
In a recent study by He et al , the nomogram integrates postoperative serum tumor markers such as carbohydrate antigen 19-9 and carcinoembryonic antigen, thereby improving the accuracy of identifying high-risk patients compared to relying …
View article: Proton pump inhibitors and all-cause mortality risk among cancer patients
Proton pump inhibitors and all-cause mortality risk among cancer patients Open
BACKGROUND Proton pump inhibitors (PPIs) are widely used, including among cancer patients, to manage gastroesophageal reflux and other gastric acid-related disorders. Recent evidence suggests associations between long-term PPI use and high…
View article: Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: A large population-based matched cohort study
Association between incretin-based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: A large population-based matched cohort study Open
GLP-1RAs and DPP-4Is were not associated with a significantly increased risk of CCA. GLP-1RAs even showed a reduced risk of CCA development. They can be considered as safe and effective treatment options for patients with T2DM at risk of C…
View article: Atorvastatin and cobicistat-elvitegravir interaction causing myopathy in the setting of biliary obstruction
Atorvastatin and cobicistat-elvitegravir interaction causing myopathy in the setting of biliary obstruction Open
View article: Electrocardiogram-Based AI for Classifying Left Ventricular Dysfunction and Heart Failure with Preserved Ejection Fraction
Electrocardiogram-Based AI for Classifying Left Ventricular Dysfunction and Heart Failure with Preserved Ejection Fraction Open
View article: Cardiovascular and mortality outcomes with GLP-1 receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study
Cardiovascular and mortality outcomes with GLP-1 receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study Open
Aims/hypothesis We aimed to determine whether the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) in individuals with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus decreases the risk of new-onset adverse…
View article: Convergence of endobariatrics and endohepatology for evaluation and treatment of obesity and nonalcoholic fatty liver disease
Convergence of endobariatrics and endohepatology for evaluation and treatment of obesity and nonalcoholic fatty liver disease Open
View article: Aspirin is associated with a reduced incidence of liver disease in men
Aspirin is associated with a reduced incidence of liver disease in men Open
Background: The hepatoprotective effects of aspirin have been observed in individuals with viral hepatitis; however, its impact on the general population remains uncertain. Understanding the association between aspirin use and the developm…
View article: Convergence of endobariatrics and endohepatology for evaluation and treatment of obesity and nonalcoholic fatty liver disease
Convergence of endobariatrics and endohepatology for evaluation and treatment of obesity and nonalcoholic fatty liver disease Open
Endohepatology is an emerging field that utilizes diagnostic and therapeutic endoscopic ultrasound (EUS) to manage liver disease. In recent years, endoscopic sleeve gastroplasty (ESG) has emerged as a safe and effective approach to treatin…
View article: Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality
Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality Open
Importance Given the burden of chronic liver disease on the health care system, more information on the hepatoprotective association of statins in the general population is needed. Objective To examine whether regular statin use is associa…