Vibeke Backer
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View article: Symptom burden in patients with chronic rhinosinusitis with nasal polyps or global airway disease prior to biologic treatment: a qualitative study of patients' experiences
Symptom burden in patients with chronic rhinosinusitis with nasal polyps or global airway disease prior to biologic treatment: a qualitative study of patients' experiences Open
Chronic rhinosinusitis with nasal polyps (CRSwNP), is a prevalent inflammatory airway disease associated with type 2 inflammation. When CRSwNP coexist with asthma, the condition is referred to as global air disease (GAD). People how lives …
View article: Restoring the Sense of Smell: A Systematic Review and Meta-Analysis of Biologic Therapies for Chronic Rhinosinusitis with Nasal Polyps
Restoring the Sense of Smell: A Systematic Review and Meta-Analysis of Biologic Therapies for Chronic Rhinosinusitis with Nasal Polyps Open
Biologics mark a paradigm shift in the management of refractory CRSwNP, offering targeted, effective and safe treatment options. However, their relative impact on psychophysical smell outcomes remains uncertain. With several biologics now …
View article: Quantitative Olfactory Dysfunction and Parosmia After <scp>COVID</scp> ‐19: An Observational Cohort Study
Quantitative Olfactory Dysfunction and Parosmia After <span>COVID</span> ‐19: An Observational Cohort Study Open
Objectives Olfactory dysfunction (OD) is a common post‐COVID‐19 condition; however its prognosis remains unclear. This study aims to describe patient characteristics across different types of post‐COVID‐19 OD (C19OD), identify factors infl…
View article: Effect of Dupilumab on Mucus Burden in Patients with Moderate-to-Severe Asthma: The VESTIGE Trial
Effect of Dupilumab on Mucus Burden in Patients with Moderate-to-Severe Asthma: The VESTIGE Trial Open
gov, ID: NCT04400318.
View article: Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry
Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition often associated with type 2 inflammation. While biologics are a promising treatment for patients with uncontrolled CRSwNP, real-world evid…
View article: Estimating the financial burden of asthma among young adults in Sweden
Estimating the financial burden of asthma among young adults in Sweden Open
Asthma in Sweden is associated with a substantial financial burden from both direct costs and asthma-related sick leave compared to matched controls, and the pooled excess burden of ICS-treated asthma in young adults exceeded €200,000,000 …
View article: Genetic and Environmental Contributions to Serological Biomarkers of Extracellular Matrix Remodeling in Asthma: A Twin Study
Genetic and Environmental Contributions to Serological Biomarkers of Extracellular Matrix Remodeling in Asthma: A Twin Study Open
Background Asthma is characterized by airway obstruction driven by chronic inflammation, leading to extracellular matrix (ECM) remodeling. This involves ECM alterations, including increased collagen deposition and elastolysis, resulting in…
View article: ULANC - EUFOREA workshop 2024: bringing the concept of global airways to the frontline of medical care
ULANC - EUFOREA workshop 2024: bringing the concept of global airways to the frontline of medical care Open
The Upper and Lower Airways Northern European Consensus (ULANC) and the European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized their first workshop in Copenhagen in January 2024. The aim of the “ Prim…
View article: Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study
Genetic Factors Explain Half of the Individual Susceptibility to Chronic Bronchitis, Airflow Obstruction and COPD Regardless of the Spirometric Definition: A Nationwide Twin Study Open
Background Smoking is a major risk factor for lung function decline and chronic obstructive pulmonary disease (COPD), but the individual susceptibility to these traits cannot be explained solely by environmental risk factors. Aim To estima…
View article: Prevalence, Change and Burden of Systemic Corticosteroid Use in Type 2 Inflammation Associated Diseases Over 25 Years – A Nationwide Danish Study
Prevalence, Change and Burden of Systemic Corticosteroid Use in Type 2 Inflammation Associated Diseases Over 25 Years – A Nationwide Danish Study Open
In type 2 inflammation associated diseases, systemic corticosteroid use remains common despite the introduction of corticosteroid-sparing treatments. Timely referrals to specialist assessment could reduce the overall systemic corticosteroi…
View article: Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion
Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion Open
Treatment targets in severe asthma have evolved towards a remission‐focused paradigm guided by precision medicine. This novel concept requires a shift from evaluating the efficacy of therapies based on a single outcome at a single time poi…
View article: Effect of Olfactory Training in <scp>COVID</scp> ‐19 Related Olfactory Dysfunction—A Placebo‐Controlled Trial
Effect of Olfactory Training in <span>COVID</span> ‐19 Related Olfactory Dysfunction—A Placebo‐Controlled Trial Open
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID‐19. However, the effectiveness of olfactory training in COVID‐19‐induced olfactory dysfunction has been studied; only a few studies…
View article: Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper
Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper Open
Exercise is an important treatment for people with asthma and should be considered alongside pharmacological therapy when developing personalised asthma management plans. Despite this, there remains limited guidance concerning the practica…
View article: Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6‐Month Trial
Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6‐Month Trial Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts patients’ quality of life (QoL). Standard treatments include nasal irrigations, nasal steroids, systemic corticosteroids, and functional endoscopic sinus su…
View article: Remission in chronic rhinosinusitis with nasal polyps
Remission in chronic rhinosinusitis with nasal polyps Open
Remission has recently been proposed as the new goal of care in CRSwNP or Nasal Polyp Syndrome by the European Forum for Research and Education in Allergy and Airway Diseases / European Position Paper on Rhinosinusitis and Nasal Polyps (EU…
View article: Raising the bar in respiratory care by EUFOREA: report of the European Union Parliament Symposium, April 2024
Raising the bar in respiratory care by EUFOREA: report of the European Union Parliament Symposium, April 2024 Open
In April 2024, the European Summit “ Raising the bar in respiratory care” was organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) in the European Parliament and hosted by Members of the Europ…
View article: EUFOREA meeting on defining disease states in allergic rhinitis: towards a unified language in AR
EUFOREA meeting on defining disease states in allergic rhinitis: towards a unified language in AR Open
Allergic rhinitis (AR), the most prevalent immunological disease, affects approximately 400 million individuals globally and can significantly impact quality of life (QoL). Despite nearly 25 years of guidelines, AR remains largely under- d…
View article: European biologic training course for type 2 inflammation by EUFOREA in 2024: key facts and lessons learned
European biologic training course for type 2 inflammation by EUFOREA in 2024: key facts and lessons learned Open
The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized the first European Biologic Training Course (EBTC) in Brussels on 1st March 2024. The aim of this hybrid EBTC including both face-to-face and…
View article: Global airway disease: mepolizumab simultaneously improves outcomes in severe CRSwNP and asthma
Global airway disease: mepolizumab simultaneously improves outcomes in severe CRSwNP and asthma Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) often co-exists with asthma and non-steroidal anti-inflammatory drug- exacerbated respiratory disease (N-ERD), creating a more severe phenotype and an additional burden compared with CRSwNP…
View article: Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma
Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma Open
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considere…
View article: Quantitative characterization of eosinophilia in nasal polyps with AI‐based single cell classification
Quantitative characterization of eosinophilia in nasal polyps with AI‐based single cell classification Open
Key points Eosinophilic granulocytes have characteristic morphological features. This makes them prime candidates for utilization of a single cell binary classification network. Single cell binary classification networks can reliably help …
View article: Lung function measurements in the Greenlandic Inuit population: results from the Greenlandic health survey 2017–2019
Lung function measurements in the Greenlandic Inuit population: results from the Greenlandic health survey 2017–2019 Open
Background Little is known about lung function in Inuit. The aim of this study was to describe lung function and the prevalence of obstructive and restrictive lung disease among Inuit in GreenlandMethods During the 2017–2019 Health Survey,…
View article: EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus
EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus Open
The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi‐annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and …
View article: Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma
Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma Open
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considere…
View article: Association between Apgar scores within normal range and development of asthma, allergic rhinitis and eczema in childhood: A Danish nationwide register study
Association between Apgar scores within normal range and development of asthma, allergic rhinitis and eczema in childhood: A Danish nationwide register study Open
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View article: Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma
Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma Open
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for year…
View article: Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma
Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1—allergic asthma Open
Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society. It is the most common chronic disease in children and represents one of the major causes for year…
View article: Respiratory impairments in patients suffering from Fabry disease – A cross-sectional study
Respiratory impairments in patients suffering from Fabry disease – A cross-sectional study Open
Background The inherited X-linked disorder, Fabry disease, is caused by deficient lysosomal enzyme α-galactosidase A, with progressive accumulation of globotriaosylceramide in multiple organs including the upper and lower airways. Objectiv…