Sathy V. Balu‐Iyer
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View article: Phosphatidylserine exposure on tolerogenic nanoparticle correlate with oral tolerance
Phosphatidylserine exposure on tolerogenic nanoparticle correlate with oral tolerance Open
Unwanted immune responses against therapeutic proteins compromise treatment safety and therapeutic efficacy in patients. To mitigate these immune responses, we developed phosphatidylserine (PS)-containing lipid nanoparticles that mimic the…
View article: Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model
Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model Open
Monoclonal antibodies (mAbs) are powerful therapeutic tools that are used to treat multiple types of human cancer as well as a diverse set of non-malignant diseases. Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice implanted with huma…
View article: Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies
Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies Open
Introduction Immunogenicity continues to be a challenge for development and clinical utility of monoclonal antibodies, and there are gaps in our current ability to prevent anti-drug antibody development in a safe and antigen-specific manne…
View article: A mechanistic marker-based screening tool to predict clinical immunogenicity of biologics
A mechanistic marker-based screening tool to predict clinical immunogenicity of biologics Open
Background The efficacy and safety of therapeutic proteins are undermined by immunogenicity driven by anti-drug antibodies. Immunogenicity risk assessment is critically necessary during drug development, but current methods lack predictive…
View article: Understanding preclinical and clinical immunogenicity risks in novel biotherapeutics development
Understanding preclinical and clinical immunogenicity risks in novel biotherapeutics development Open
Immunogenicity continues to pose a challenge in the development of biotherapeutics like conventional therapeutic-proteins and monoclonal antibodies as well as emerging modalities such as gene-therapy components, gene editing, and CAR T cel…
View article: Supplemental Figure S1 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S1 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S1. Delipidation of ascites fluid.
View article: Supplementary Table 1 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Supplementary Table 1 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
List of reagents used in flow cytometry and fluorescence microscopy
View article: Supplemental Figure S2 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S2 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S2. PS/PC liposome titration.
View article: Supplementary Figures 1 - 4 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Supplementary Figures 1 - 4 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
S1: Exosome derived from different ascites fluids show varying degrees of inhibition. S2: Exosomes do not affect T cell death following activation. S3: Exosomes inhibit IL-2 production by T cells. S4: Exosomes inhibit IFN-gamma production …
View article: Data from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Data from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
Nano-sized membrane-encapsulated extracellular vesicles isolated from the ascites fluids of ovarian cancer patients are identified as exosomes based on their biophysical and compositional characteristics. We report here that T cells pulsed…
View article: Supplemental Methods and Figure Legends from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Methods and Figure Legends from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Description of additional methods and figure legends for Supplemental Figures
View article: Supplementary Table 1 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Supplementary Table 1 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
List of reagents used in flow cytometry and fluorescence microscopy
View article: Data from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Data from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. We previously established that an unidentified…
View article: Supplemental Figure S3 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S3 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S3. Sorting of lymphocytes into CD4+ and CD8+ subsets.
View article: Supplemental Figure S3 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S3 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S3. Sorting of lymphocytes into CD4+ and CD8+ subsets.
View article: Supplemental Figure S4 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S4 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S4. Biophysical characterization of exosomes.
View article: Supplemental Figure S1 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S1 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S1. Delipidation of ascites fluid.
View article: Supplemental Figure S6 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S6 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S6. EVs directly inhibit CD4+ and CD8+ T cell activation
View article: Supplemental Figure S5 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S5 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S5. EVs inhibit CD69 upregulation of CD4+ and CD8+ T cells.
View article: Supplementary Figures 1 - 4 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Supplementary Figures 1 - 4 from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
S1: Exosome derived from different ascites fluids show varying degrees of inhibition. S2: Exosomes do not affect T cell death following activation. S3: Exosomes inhibit IL-2 production by T cells. S4: Exosomes inhibit IFN-gamma production …
View article: Data from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses
Data from Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses Open
Nano-sized membrane-encapsulated extracellular vesicles isolated from the ascites fluids of ovarian cancer patients are identified as exosomes based on their biophysical and compositional characteristics. We report here that T cells pulsed…
View article: Supplemental Figure S5 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S5 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S5. EVs inhibit CD69 upregulation of CD4+ and CD8+ T cells.
View article: Supplemental Methods and Figure Legends from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Methods and Figure Legends from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Description of additional methods and figure legends for Supplemental Figures
View article: Supplemental Figure S4 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S4 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S4. Biophysical characterization of exosomes.
View article: Supplemental Figure S6 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S6 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S6. EVs directly inhibit CD4+ and CD8+ T cell activation
View article: Supplemental Figure S2 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Supplemental Figure S2 from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
Fig S2. PS/PC liposome titration.
View article: Data from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade
Data from Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade Open
The identification of immunosuppressive factors within human tumor microenvironments, and the ability to block these factors, would be expected to enhance patients' antitumor immune responses. We previously established that an unidentified…