Explanipedia

Erratum to “The role of Monte Carlo simulation in understanding the performance of proton computed tomography” [Z Med Phys 32 (2022) 23–38] Open

G. Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah , et al. · 2024

A Prototype Scintillator Real-Time Beam Monitor for Ultra-high Dose Rate Radiotherapy. Open

Daniel S Levin, Peter S. Friedman, Claudio Ferretti, Nicholas Ristow, M. Tecchio , et al. · 2024

The FBSM is designed to provide real-time beam profile monitoring over a large active area without significantly degrading the beam quality. A prototype device has been staged in particle beams at currents of single particles up to FLASH l…

A prototype scintillator real‐time beam monitor for ultra‐high dose rate radiotherapy Open

Daniel Levin, Peter S. Friedman, Claudio Ferretti, Nicholas Ristow, M. Tecchio , et al. · 2024

Background FLASH Radiotherapy (RT) is an emergent cancer RT modality where an entire therapeutic dose is delivered at more than 1000 times higher dose rate than conventional RT. For clinical trials to be conducted safely, a precise and fas…

A Prototype Scintillator Real-Time Beam Monitor for Ultra-high Dose Rate Radiotherapy Open

Daniel Levin, Claudio Ferretti, Nicholas Ristow, M. Tecchio, Peter S. Friedman , et al. · 2023

FLASH Radiotherapy (RT) is a potentially new cancer radiotherapy technique where an entire therapeutic dose is delivered in about 0.1 s and at ~1000 times higher dose rate than in conventional RT. For clinical trials to be conducted safely…

Current status of the preclinical evaluation of alternating electric fields as a form of cancer therapy Open

Christoph Pohling, Ha Nguyen, Edwin Chang, Keith E. Schubert, Ying Nie , et al. · 2022

Exposing cancer cells to alternating electric fields of 100-300 kHz frequency and 1-4 V/cm strength has been shown to significantly reduce cancer growth in cell culture and in human patients. This form of anti-cancer therapy is more common…

Comparative accuracy and resolution assessment of two prototype proton computed tomography scanners Open

G. Dedes, Hubertus Drosten, S. A. Gotz, Jannis Dickmann, Christina Sarosiek , et al. · 2022

Background Improving the accuracy of relative stopping power (RSP) in proton therapy may allow reducing range margins. Proton computed tomography (pCT) has been shown to provide state‐of‐the‐art RSP accuracy estimation, and various scanner…

Particle-Tracking Proton Computed Tomography—Data Acquisition, Preprocessing, and Preconditioning Open

Blake Schultze, Paniz Karbasi, Christina Sarosiek, G. Coutrakon, C.E. Ordoñez , et al. · 2021

Proton CT (pCT) is a promising new imaging technique that can reconstruct relative stopping power (RSP) more accurately than x-ray CT in each cubic millimeter voxel of the patient. This, in turn, will result in better proton range accuracy…

The role of Monte Carlo simulation in understanding the performance of proton computed tomography Open

G. Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah , et al. · 2020

Experimental comparison of proton CT and dual energy x-ray CT for relative stopping power estimation in proton therapy Open

G. Dedes, Jannis Dickmann, Katharina Niepel, Philipp Wesp, R. P. Johnson , et al. · 2019

Proton computed tomography (pCT) has been proposed as an alternative to x-ray computed tomography (CT) for acquiring relative to water stopping power (RSP) maps used for proton treatment planning dose calculations. In parallel, it has been…

Understanding image artifacts for a prototype proton computed tomography scanner via Monte Carlo simulations Open

Jannis Dickmann, Philipp Wesp, Simon Rit, Mark Pankuch, Robert T. Johnson , et al. · 2019

International audience

Prediction of image noise contributions in proton computed tomography and comparison to measurements Open

Jannis Dickmann, Philipp Wesp, Martin Rädler, Simon Rit, Mark Pankuch , et al. · 2019

We present a method to accurately predict image noise in proton computed tomography (pCT) using data generated from a Monte Carlo simulation and a patient or object model that may be generated from a prior x-ray CT image. This enables nois…

Accuracy of low‐dose proton CT image registration for pretreatment alignment verification in reference to planning proton CT Open

Roberto Cassetta, Pierluigi Piersimoni, Marco Riboldi, Valentina Giacometti, V. Bashkirov , et al. · 2019

Purpose Proton CT ( pCT ) has the ability to reduce inherent uncertainties in proton treatment by directly measuring the relative proton stopping power with respect to water, thereby avoiding the uncertain conversion of X‐ray CT Hounsfield…

Robust iterative methods: Convergence and applications to proton computed tomography Open

Paniz Karbasi, Keith E. Schubert, Blake Schultze, V. Bashkirov, R. P. Johnson , et al. · 2019

Robust methods, such as Tikhonov regularization and Bounded data uncertainty, have been used extensively in relatively small problems involving dense matrices for many decades, but have not been used in large-scale iterative methods for im…

The impact of secondary fragments on the image quality of helium ion imaging Open

Lennart Volz, Pierluigi Piersimoni, V. Bashkirov, Stephan Brons, Charles‐Antoine Collins‐Fekete , et al. · 2018

Single-event ion imaging enables the direct reconstruction of the relative stopping power (RSP) information required for ion-beam therapy. Helium ions were recently hypothesized to be the optimal species for such technique. The purpose of …

A Highly Accelerated Parallel Multi-GPU based Reconstruction Algorithm for Generating Accurate Relative Stopping Powers Open

Paniz Karbasi, Ritchie Cai, Blake Schultze, Hanh H. Nguyen, Jones Reed , et al. · 2017

Low-dose Proton Computed Tomography (pCT) is an evolving imaging modality that is used in proton therapy planning which addresses the range uncertainty problem. The goal of pCT is generating a 3D map of Relative Stopping Power (RSP) measur…

Stopping power accuracy and achievable spatial resolution of helium ion imaging using a prototype particle CT detector system Open

Lennart Volz, Charles‐Antoine Collins‐Fekete, Pierluigi Piersimoni, R. P. Johnson, V. Bashkirov , et al. · 2017

A precise relative stopping power map of the patient is crucial for accurate particle therapy. Charged particle imaging determines the stopping power either tomographically – particle computed tomography (pCT) – or by combining prior knowl…

Software platform for simulation of a prototype proton CT scanner Open

Valentina Giacometti, V. Bashkirov, Pierluigi Piersimoni, Susanna Guatelli, Tia Plautz , et al. · 2017

Purpose Proton computed tomography ( pCT ) is a promising imaging technique to substitute or at least complement x‐ray CT for more accurate proton therapy treatment planning as it allows calculating directly proton relative stopping power …

The effect of beam purity and scanner complexity on proton CT accuracy Open

Pierluigi Piersimoni, José Ramos‐Méndez, Theodore Geoghegan, V. Bashkirov, R. Schulte , et al. · 2017

Purpose To determine the dependence of the accuracy in reconstruction of relative stopping power ( RSP ) with proton computerized tomography ( pCT ) scans on the purity of the proton beam and the technological complexity of the pCT scanner…

Session 24: Imaging and image processing II – X-Ray and multimodal imaging Open

Pierluigi Piersimoni, V. Bashkirov, Bruce Faddegon, José Ramos‐Méndez, R. Schulte , et al. · 2017

Results from a Prototype Proton-CT Head Scanner Open

R. P. Johnson, V. Bashkirov, G. Coutrakon, Valentina Giacometti, Paniz Karbasi , et al. · 2017

An evaluation of spatial resolution of a prototype proton CT scanner Open

Tia Plautz, V. Bashkirov, Valentina Giacometti, Robert F. Hurley, R. P. Johnson , et al. · 2016

Purpose: To evaluate the spatial resolution of proton CT using both a prototype proton CT scanner and Monte Carlo simulations. Methods: A custom cylindrical edge phantom containing twelve tissue‐equivalent inserts with four different compo…

A scintillator‐based approach to monitor secondary neutron production during proton therapy Open

Shaun D. Clarke, E. Pryser, Brian M. Wieger, Sara A. Pozzi, R. A. Haelg , et al. · 2016

Purpose The primary objective of this work is to measure the secondary neutron field produced by an uncollimated proton pencil beam impinging on different tissue‐equivalent phantom materials using organic scintillation detectors. Additiona…

Operation of the preclinical head scanner for proton CT Open

H. F-W. Sadrozinski, Theodore Geoghegan, Evan Harvey, R. P. Johnson, Tia Plautz , et al. · 2016

We report on the operation and performance tests of a preclinical head scanner developed for proton computed tomography (pCT). After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment plann…

Novel scintillation detector design and performance for proton radiography and computed tomography Open

V. Bashkirov, R. Schulte, Robert F. Hurley, R. P. Johnson, H. F-W. Sadrozinski , et al. · 2016

Purpose: Proton computed tomography (pCT) will enable accurate prediction of proton and ion range in a patient while providing the benefit of lower radiation exposure than in x‐ray CT. The accuracy of the range prediction is essential for …

A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience With Phantom Scans Open

R. P. Johnson, V. Bashkirov, H. Langley DeWitt, Valentina Giacometti, Robert F. Hurley , et al. · 2015

We report on the design, fabrication, and first tests of a tomographic scanner developed for proton computed tomography (pCT) of head-sized objects. After extensive preclinical testing, pCT is intended to be employed in support of proton t…

A Proton CT Imaging System for Improving the Accuracy of Particle Treatment Planning and Delivery: Monte Carlo Simulations and First Experimental Results Open

R. Schulte, V. Bashkirov, Valentina Giacometti, Robert F. Hurley, M.E. Johnson , et al. · 2015

Development of proton computed tomography detectors for applications in hadron therapy Open

V. Bashkirov, R. P. Johnson, H. F-W. Sadrozinski, R. Schulte · 2015

Characterisation of a track structure imaging detector Open

Margherita Casiraghi, V. Bashkirov, Robert F. Hurley, R. Schulte · 2015

The spatial distribution of radiation-induced ionisations in sub-cellular structures plays an important role in the initial formation of radiation damage to biological tissues. Using the nanodosimetry approach, physical characteristics of …

OC-0411: Design and performance of a preclinical proton CT head scanner Open

R. Schulte, V. Bashkirov, Valentina Giacometti, Robert F. Hurley, R. P. Johnson , et al. · 2015

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