Vincenzo Belcastro
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View article: Epilepsy beyond seizures: embracing a holistic perspective. Proceedings of the 2nd meeting (Episicily) of the epilepsy study group of the Italian Society of neurology
Epilepsy beyond seizures: embracing a holistic perspective. Proceedings of the 2nd meeting (Episicily) of the epilepsy study group of the Italian Society of neurology Open
The purpose of the second meeting of the Epilepsy Study Group of the Italian Society of Neurology, held in Sicily, Italy, and titled "Episicily" was on a new holistic approach to people with epilepsy. The most important points that the exp…
View article: Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy
Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy Open
Treatment discontinuation in epilepsy emerges as a dynamic process shaped by both tolerability and clinical response. Early persistence was higher for LCM, whereas long-term retention was improved for BRV and PER. These results support a p…
View article: Utility and limitations of homemade videos in differentiating functional seizures from other paroxysmal events: An Italian cohort study
Utility and limitations of homemade videos in differentiating functional seizures from other paroxysmal events: An Italian cohort study Open
Objectives The gold standard for distinguishing epileptic seizures (ES) from non‐epileptic events is video‐EEG monitoring. In some cases, video alone might suffice, leading to increased utilization of home videos, to support the diagnosis.…
View article: Effectiveness and safety of adjunctive cenobamate in people with focal‐onset epilepsy: Interim results after 24‐week observational period from the <scp>BLESS</scp> study
Effectiveness and safety of adjunctive cenobamate in people with focal‐onset epilepsy: Interim results after 24‐week observational period from the <span>BLESS</span> study Open
Objective Cenobamate is an antiseizure medication (ASM) with a dual mechanism of action that was recently approved for the treatment of focal seizures in adults. This analysis aimed to describe the outcomes at 12 and 24 weeks after startin…
View article: Pharmacodynamic rationale for the choice of antiseizure medications in the paediatric population
Pharmacodynamic rationale for the choice of antiseizure medications in the paediatric population Open
In the landscape of paediatric epilepsy treatment, over 20 anti-seizure medications (ASMs) have gained approval from Drug Regulatory Agencies, each delineating clear indications. However, the complexity of managing drug-resistant epilepsy …
View article: Myoclonus: Differential diagnosis and current management
Myoclonus: Differential diagnosis and current management Open
Myoclonus classically presents as a brief (10–50 ms duration), non‐rhythmic jerk movement. The etiology could vary considerably ranging from self‐limited to chronic or even progressive disorders, the latter falling into encephalopathic pic…
View article: A real‐world comparison among third‐generation antiseizure medications: Results from the <scp>COMPARE</scp> study
A real‐world comparison among third‐generation antiseizure medications: Results from the <span>COMPARE</span> study Open
Objective There are few comparative data on the third‐generation antiseizure medications (ASMs). We aimed to assess and compare the effectiveness of brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) …
View article: Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP)
Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP) Open
Background Cyclic Vomiting Syndrome (CVS) is a rare functional gastrointestinal disorder, which has a considerable burden on quality of life of both children and their family. Aim of the study was to evaluate the diagnostic modalities and …
View article: Additional file 5 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge
Additional file 5 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge Open
Additional file 5.
View article: Additional file 2 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge
Additional file 2 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge Open
Additional file 2.
View article: Additional file 1 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge
Additional file 1 of Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge Open
Additional file 1.
View article: Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)
Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST) Open
Background: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic setting are a useful complement to characterize the drug p…
View article: Clinical and Genetic Features in Patients With Reflex Bathing Epilepsy
Clinical and Genetic Features in Patients With Reflex Bathing Epilepsy Open
Objective: To describe the clinical and genetic findings in a cohort of subjects with bathing epilepsy, a rare form of reflex epilepsy. Methods: We investigated by Sanger and targeted re-sequencing the SYN1 gene in 12 individuals from 10 d…
View article: Perampanel Confirms to Be Effective and Well-Tolerated as an Add-On Treatment in Patients With Brain Tumor-Related Epilepsy (PERADET Study)
Perampanel Confirms to Be Effective and Well-Tolerated as an Add-On Treatment in Patients With Brain Tumor-Related Epilepsy (PERADET Study) Open
Background: Epilepsy is one of the most common symptoms of brain tumors. It is often drug resistant and generally worsen patients' quality of life (QoL). Brain tumors release glutamate among other mediators, contributing to seizures onset,…
View article: What place do carbamazepine-related antiepileptic drugs have in the modern day treatment of epilepsy?
What place do carbamazepine-related antiepileptic drugs have in the modern day treatment of epilepsy? Open
Carbamazepine (CBZ), oxcarbazepine (OXC), and eslicarbazepine acetate (ESL) are all members of the dibenzazepine carboxamide family. CBZ is the oldest in this class of antiseizure medications (ASMs...