P. Ferrero
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View article: Use of Cannabidiol-Dominant Extract as Co-Adjuvant Therapy for Type 2 Diabetes Mellitus Treatment in Feline: Case Report
Use of Cannabidiol-Dominant Extract as Co-Adjuvant Therapy for Type 2 Diabetes Mellitus Treatment in Feline: Case Report Open
Introduction: Diabetes mellitus (DM) is a common endocrinopathy in felines. Treatment is based on glycemic control and management of clinical signs by insulin administration coupled with a low-carbohydrate and high-protein content diet. Ho…
View article: Revealing the characteristics of the dark GRB 150309A: Dust extinguished or high-<i>z</i>?
Revealing the characteristics of the dark GRB 150309A: Dust extinguished or high-<i>z</i>? Open
Context. Dark gamma-ray bursts (GRBs) constitute a significant fraction of the GRB population. In this paper, we present a multi-wavelength analysis (both prompt emission and afterglow) of an intense (3.98 × 10 −5 erg cm −2 using Fermi -Ga…
View article: Circulating microRNAs as biomarkers of Chagas cardiomyopathy
Circulating microRNAs as biomarkers of Chagas cardiomyopathy Open
Background Chagas cardiomyopathy (CHCM) is the most important clinical manifestation of Chagas disease. The analysis of cardiac miRNAs may contribute to predicting the progression to CHCM in Chagas indeterminate phase and/or to the differe…
View article: Revealing characteristics of dark GRB 150309A: dust extinguished or high-z?
Revealing characteristics of dark GRB 150309A: dust extinguished or high-z? Open
Dark GRBs constitute a significant fraction of the GRB population. In this paper, we present the multiwavelength analysis of an intense two-episodic GRB 150309A observed early on to ~114 days post-burst. Despite the strong gamma-ray emissi…
View article: Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides
Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides Open
Muscle contraction depends on strictly controlled Ca 2+ transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase, SERCA. Activity of SERCA is regulated by binding of mic…
View article: Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart
Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart Open
Appropriate cardiac performance depends on a tightly controlled handling of Ca 2+ in a broad range of species, from invertebrates to mammals. The role of the Ca 2+ ATPase, SERCA, in Ca 2+ handling is pivotal, and its activity is regulated,…
View article: A low-cost Portable Device to Deliver Smoke, Volatile or Vaporized Substances to Drosophila melanogaster, Useful for Research and/or Educational Assays
A low-cost Portable Device to Deliver Smoke, Volatile or Vaporized Substances to Drosophila melanogaster, Useful for Research and/or Educational Assays Open
Drosophila melanogaster has been used to test drugs of abuse, substances with potential benefits for medical purposes, as well as contaminants and hazardous volatile compounds. This model has also been used for the characterization of beha…
View article: Smoking flies: testing the effect of tobacco cigarettes on heart function of<i>Drosophila melanogaster</i>
Smoking flies: testing the effect of tobacco cigarettes on heart function of<i>Drosophila melanogaster</i> Open
Studies about the relationship between substances consumed by humans and their impact on health, in animal models, have been a challenge due to differences between species in the animal kingdom. However, the homology of certain genes has a…
View article: Inhalation of marijuana affects <i>Drosophila</i> heart function
Inhalation of marijuana affects <i>Drosophila</i> heart function Open
We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the e…
View article: Inhalation of marijuana affects <i>Drosophila</i> heart function
Inhalation of marijuana affects <i>Drosophila</i> heart function Open
Medical uses of marijuana have been recently approved in many countries, and after a long ban on research, there is despicable scientific evidence regarding its action and side effects. We investigated the effect of inhalation of vaporized…
View article: SERCA is critical to control the Bowditch effect in the heart
SERCA is critical to control the Bowditch effect in the heart Open
The Bowditch effect or staircase phenomenon is the increment or reduction of contractile force when heart rate increases, defined as either a positive or negative staircase. The healthy and failing human heart both show positive or negativ…
View article: Transition from Fireball to Poynting-flux-dominated Outflow in Three-Episode GRB 160625B
Transition from Fireball to Poynting-flux-dominated Outflow in Three-Episode GRB 160625B Open
The ejecta composition is an open question in gamma-ray bursts (GRB) physics. Some GRBs possess a quasi-thermal spectral component in the time-resolved spectral analysis, suggesting a hot fireball origin. Others show a featureless non-ther…
View article: Transition from fireball to Poynting-flux-dominated outflow in three-episode GRB 160625B [submitted version]
Transition from fireball to Poynting-flux-dominated outflow in three-episode GRB 160625B [submitted version] Open
The ejecta composition of gamma-ray bursts (GRBs) is an open question in GRB physics. Some GRBs possess a quasi-thermal spectral component in the time-resolved spectral analysis, suggesting a hot fireball origin. Some others show an essent…