Victor W. Henderson
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View article: The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias
The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias Open
INTRODUCTION The Neighborhoods Study (TNS) is a novel investigation of adverse social exposome and brain health leveraging 22 Alzheimer's Disease Research Centers (ADRCs). TNS aims to understand if the adverse social exposures increase Alz…
View article: Long-read genome sequencing and multi-omics in aging and neurodegeneration
Long-read genome sequencing and multi-omics in aging and neurodegeneration Open
Structural variants (SVs) are a major source of genetic variation yet remain underexplored in healthy aging and neurodegenerative diseases. We performed nanopore long-read genome sequencing (lrGS) on 551 deeply-phenotyped individuals from …
View article: Protocol for the Asian Cohort for Alzheimer's Disease (ACAD) Study
Protocol for the Asian Cohort for Alzheimer's Disease (ACAD) Study Open
INTRODUCTION To address knowledge gaps in Alzheimer's disease (AD) research, the Asian Cohort for Alzheimer's Disease (ACAD) Study will recruit over 5000 participants of Asian descent aged 60 or older in the United States and Canada. The c…
View article: Plasma phosphorylated tau 217 detects amyloid-β in Neuronal Synuclein Disease
Plasma phosphorylated tau 217 detects amyloid-β in Neuronal Synuclein Disease Open
Background Multiple proteinopathies commonly coexist in neurodegenerative diseases, therefore it is critical to understand plasma biomarker performance to detect proteinopathies in these complex diseases. While plasma biomarkers can accura…
View article: Effects of α-synuclein pathology in normal aging and Alzheimer’s disease
Effects of α-synuclein pathology in normal aging and Alzheimer’s disease Open
Objective α-synuclein is the hallmark pathology of Parkinson’s disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). α-synuclein is also commonly observed in the context of Alzheimer’s disease (AD). Here we …
Denoising 7T Structural MRI with Conditional Generative Diffusion Models Open
Purpose 7T MRI offers ultra-high resolution and improved sensitivity for iron deposition in neurodegenerative disorders, but commonly used acquisitions are long and hence challenging, especially for elderly subjects. Efficiently denoising …
View article: Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study
Obstructive sleep apnoea and risk of dementia: a Danish population-based cohort study Open
Background Obstructive sleep apnoea (OSA) is associated with adverse health outcomes. However, the association with dementia remains uncertain. Thus, we examined the association of OSA with all-cause dementia and Alzheimer’s disease. Metho…
View article: Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction
Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction Open
Recent studies demonstrate that Parkinson’s disease (PD) is associated with dysregulated metabolic flux through the kynurenine pathway (KP), in which tryptophan is converted to kynurenine (KYN), and KYN is subsequently metabolized to neuro…
View article: Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson’s disease
Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson’s disease Open
Parkinson's disease (PD) is primarily diagnosed through its characteristic motor deficits, yet it also encompasses progressive cognitive impairments that profoundly affect quality of life. While dopaminergic medications are routinely presc…
View article: Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort
Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort Open
INTRODUCTION Amyloid positron emission tomography (PET) is increasingly available for diagnosis of Alzheimer`s disease (AD); however, its practical implications in heterogenous cohorts are debated. METHODS Amyloid PET from 890 National Alz…
View article: Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease Open
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate ‘pro-aging’ or ‘pro-youthful’ effects on the mouse brain. The clinical relevance and combined effec…
View article: Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub> is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub> is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum Open
INTRODUCTION The availability of amyloid beta (Aβ) targeting therapies for Alzheimer's disease (AD) is increasing the demand for scalable biomarkers that are sensitive to early cerebral Aβ accumulation. METHODS We evaluated fully‐automated…
View article: 18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease
18F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease Open
Co-pathology is frequent in Lewy body disease, which includes clinical diagnoses of both Parkinson’s disease and dementia with Lewy bodies. Measuring concomitant pathology in vivo can improve clinical and research diagnoses and prediction …
View article: VEGF and ICAM5 Levels in Alzheimer’s Disease and Cognitively Healthy Aging
VEGF and ICAM5 Levels in Alzheimer’s Disease and Cognitively Healthy Aging Open
Background Vascular dysfunction, blood‐brain barrier (BBB) dysregulation, and neuroinflammation are thought to participate in Alzheimer`s disease (AD) pathogenesis, though the mechanism is poorly understood. Among pathways of interest, AD …
View article: Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging
Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging Open
Background α‐Synuclein is the hallmark pathology of Parkinson’s disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). α‐Synuclein is also commonly observed in the context of Alzheimer’s disease (AD). Here we…
View article: Asian Cohort for Alzheimer’s Disease (ACAD) Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians
Asian Cohort for Alzheimer’s Disease (ACAD) Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians Open
Background Asian Americans and Asian Canadians (ASACs) are the fastest growing minority group in the US and Canada. However, ASACs are under‐sampled in Alzheimer’s disease (AD) research. To address the need of culturally appropriate clinic…
Misperception of night‐to‐night sleep quality in Alzheimer’s and Lewy body disease Open
Background Objective sleep measures obtained from actigraphy (wrist‐worn accelerometry) reveal sleep disruption patterns and may serve as indicators of neurodegenerative disease. However, whether individuals’ subjective account of their sl…
View article: Elevated tau in the piriform cortex in Alzheimer’s but not Parkinson’s disease using MR‐PET
Elevated tau in the piriform cortex in Alzheimer’s but not Parkinson’s disease using MR‐PET Open
Background Olfactory deficiency can be present in preclinical Alzheimer’s (AD) and Parkinson’s disease (PD), predicting their subsequent manifestation, including mild cognitive impairment (MCI). Analyzing key regions within the olfactory c…
View article: Comparing the diagnostic performance of plasma pTau181 and pTau217 for the identification of Alzheimer’s disease co‐pathology in Lewy Body Disease
Comparing the diagnostic performance of plasma pTau181 and pTau217 for the identification of Alzheimer’s disease co‐pathology in Lewy Body Disease Open
Background Lewy body disease (LBD) often co‐occurs with Alzheimer’s disease neuropathological change (ADNC), which can be detected using plasma pTau181 and pTau217. Few studies have investigated these biomarkers in LBD, nor have studies in…
View article: Over‐Representation of Extremely Wealthy Neighborhood Social Exposomes for Brain Donors within Alzheimer’s Disease Research Center Brain Banks assessed by the Neighborhoods Study
Over‐Representation of Extremely Wealthy Neighborhood Social Exposomes for Brain Donors within Alzheimer’s Disease Research Center Brain Banks assessed by the Neighborhoods Study Open
Background Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80‐100 or ‘high ADI’) is linked to structural inequities and increased risk of Alzheimer’s disease neuropathology. Twenty percent of the US population res…
Evidence for a protective effect of hormone replacement therapy on Alzheimer’s disease neuropathological and clinical outcomes across cohorts Open
Background More than 2/3 of Alzheimer’s Disease (AD) patients are women, which has led to increased interest in the neurophysiological impact of estrogen decline during menopause. While early evidence suggested that hormone replacement the…
View article: Amyloid-β predominant Alzheimer’s disease neuropathologic change
Amyloid-β predominant Alzheimer’s disease neuropathologic change Open
Different subsets of Alzheimer’s disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic…
View article: Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR
Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR Open
INTRODUCTION Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison …
Myeloproliferative Neoplasms and Dementia Risk: A Population‐Based Cohort Study Open
Objectives To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model. Methods We identified 9895 individuals in Denmark newl…