Kumar Das
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View article: Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy
Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy Open
Structural neuroimaging analyses require “research quality” images, procured with costly MRI acquisitions. Isotropic (3D-T1) images are desirable for quantitative analyses, however, a routine compromise in the clinical setting is to acquir…
Intraoperative Hypotension Prediction: Proactive Perioperative Hemodynamic Management Open
Intraoperative hypotension (IOH) is a frequent complication during surgery, associated with adverse outcomes such as acute kidney injury, myocardial infarction, and increased mortality. Recent developments have proactively improved the abi…
Perioperative Medicine: Investigating Preoperative and Postoperative Management, Including Reducing Complications in Diabetic and Obese Patients Open
Perioperative medicine is crucial for optimizing outcomes for patients with comorbidities like diabetes and obesity. It involves a multidisciplinary approach to preoperative assessment, intraoperative management, and postoperative care to …
Perioperative Medicine: Investigating Preoperative and Postoperative Management, Including Reducing Complications in Diabetic and Obese Patients Open
Perioperative medicine is crucial for optimizing outcomes for patients with comorbidities like diabetes and obesity. It involves a multidisciplinary approach to preoperative assessment, intraoperative management, and postoperative care to …
Machine Learning-Based Reconstruction of 2D MRI for Quantitative Morphometry in Epilepsy Open
Introduction Structural neuroimaging analyses require ‘research quality’ images, acquired with costly MRI acquisitions. Isotropic (3D-T1) images are desirable for quantitative analyses, however a routine compromise in the clinical setting …
View article: Clinical predictors of encephalitis in UK adults–A multi-centre prospective observational cohort study
Clinical predictors of encephalitis in UK adults–A multi-centre prospective observational cohort study Open
Objectives Encephalitis, brain inflammation and swelling, most often caused by an infection or the body’s immune defences, can have devastating consequences, especially if diagnosed late. We looked for clinical predictors of different type…
Supplementary methods from T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes Open
supplementary data on IHC stains and image files
Supplementary methods from T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes Open
supplementary data on IHC stains and image files
Data from T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes Open
Brain metastases are common and are usually detected by MRI. Diffusion tensor imaging (DTI) is a derivative MRI technique that can detect disruption of white matter tracts in the brain. We have matched preoperative DTI with image-guided sa…
Data from T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes Open
Brain metastases are common and are usually detected by MRI. Diffusion tensor imaging (DTI) is a derivative MRI technique that can detect disruption of white matter tracts in the brain. We have matched preoperative DTI with image-guided sa…
Protocol for an observational cohort study investigating biomarkers predicting seizure recurrence following a first unprovoked seizure in adults Open
Introduction A first unprovoked seizure is a common presentation, reliably identifying those that will have recurrent seizures is a challenge. This study will be the first to explore the combined utility of serum biomarkers, quantitative e…
Midbrain structure volume, estimated myelin and functional connectivity in idiopathic generalised epilepsy Open
Background Previous neuroimaging studies reported functional and structural impairments of the upper basal ganglia (specifically, the striatum) in idiopathic generalised epilepsy (IGE). However, these studies often overlook lower basal gan…
Automated subcortical volume estimation from 2D MRI in epilepsy and implications for clinical trials Open
Purpose Most techniques used for automatic segmentation of subcortical brain regions are developed for three-dimensional (3D) MR images. MRIs obtained in non-specialist hospitals may be non-isotropic and two-dimensional (2D). Automatic seg…
Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy Open
It is well established that abnormal thalamocortical systems play an important role in the generation and maintenance of primary generalised seizures. However, it is currently unknown which thalamic nuclei and how nuclear‐specific thalamoc…
Altered Structural Brain Networks in Refractory and Nonrefractory Idiopathic Generalized Epilepsy Open
Introduction: Idiopathic generalized epilepsy (IGE) is a collection of generalized nonlesional epileptic network disorders. Around 20-40% of patients with IGE are refractory to antiseizure medication, and mechanisms underlying refractorine…
Protocol for DexEnceph: a randomised controlled trial of dexamethasone therapy in adults with herpes simplex virus encephalitis Open
Introduction Herpes simplex virus (HSV) encephalitis is a rare severe form of brain inflammation that commonly leaves survivors and their families with devastating long-term consequences. The virus particularly targets the temporal lobe of…
Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study Open
Despite an increasing number of drug treatment options for people with idiopathic generalized epilepsy (IGE), drug resistance remains a significant issue and the mechanisms underlying it remain poorly understood. Previous studies have larg…
Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance Open
Despite an expanding literature on brain alterations in patients with longstanding epilepsy, few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE). Understanding brain network impairments at diagnosis is …
Thalamohippocampal atrophy in focal epilepsy of unknown cause at the time of diagnosis Open
Background and purpose Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal e…
Thalamohippocampal atrophy in focal epilepsy of unknown cause at the time of diagnosis Open
Background Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal epilepsy (NDf…
Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study Open
Neuropsychological and psychiatric outcomes after encephalitis vary according to aetiology. Memory and naming are severely affected in HSV, and less so in other forms. Neuropsychological functioning improves over time, particularly in thos…
Resting‐state functional brain networks in adults with a new diagnosis of focal epilepsy Open
Objectives Newly diagnosed focal epilepsy (NDfE) is rarely studied, particularly using advanced neuroimaging techniques. Many patients with NDfE experience cognitive impairments, particularly with respect to memory, sustained attention, me…
Neuroradiological findings in patients with “non-lesional” focal epilepsy revealed by research protocol Open
The primary factors explaining the newly identified lesions were the choice of MRI sequences, imaging parameters, data quality, lesion not reported (human factor), and loss of information through incomplete documentation. It is important f…