Vivek Narayan
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View article: Cancer cell-intrinsic mechanisms controlling the immune response to non-muscle-invasive bladder cancer 3077
Cancer cell-intrinsic mechanisms controlling the immune response to non-muscle-invasive bladder cancer 3077 Open
Description The majority of urothelial carcinomas are diagnosed as non-muscle-invasive bladder cancer (NMIBC). Standard of care treatment for NMIBC includes tumor resection followed by intravesical administration of bacillus Calmette-Guéri…
View article: HLA class I expression shapes the tumor immune microenvironment and influences prognosis in prostate cancer
HLA class I expression shapes the tumor immune microenvironment and influences prognosis in prostate cancer Open
Background Human leukocyte antigen (HLA) class I encompasses peptide-binding proteins that regulate T-cell interactions. We examined HLA class I expression in prostate cancers (PC), exploring associations with clinical outcomes, molecular …
View article: 42The impact of belzutifan on tumor reduction procedures and healthcare resource utilization in von hippel–lindau (VHL) disease
42The impact of belzutifan on tumor reduction procedures and healthcare resource utilization in von hippel–lindau (VHL) disease Open
Background Belzutifan, a hypoxia-inducible factor 2 alpha inhibitor, was approved in the United States in August 2021 to treat VHL-associated renal cell carcinoma (RCC), central nervous system hemangioblastomas (CNS-Hb), and pancreatic neu…
View article: Hypocalcemia as a Predictor of Mortality in Trauma Patients: A Systematic Review and Meta-analysis
Hypocalcemia as a Predictor of Mortality in Trauma Patients: A Systematic Review and Meta-analysis Open
Hypocalcemia is commonly observed in trauma patients and has been linked to adverse clinical outcomes. However, its role as a predictor of mortality remains unclear. This systematic review and meta-analysis aim to evaluate the association …
View article: The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2
The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2 Open
Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate cell cycle progression. This approach uncovere…
View article: Enhancing Radiation Therapy Response in Prostate Cancer Through Metabolic Modulation by Mito-Lonidamine: A 1H and 31P Magnetic Resonance Spectroscopy Study
Enhancing Radiation Therapy Response in Prostate Cancer Through Metabolic Modulation by Mito-Lonidamine: A 1H and 31P Magnetic Resonance Spectroscopy Study Open
Radiation therapy (RT) is the cornerstone treatment for prostate cancer; however, it frequently induces gastrointestinal and genitourinary toxicities that substantially diminish the patients’ quality of life. While many individuals experie…
View article: The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2
The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2 Open
Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate cell cycle progression. This approach uncovere…
View article: Figure S2 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S2 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Impact of EGR2 knockout on CD8+/CD4+ ratio and Th2 cytokine production in the setting of chronic tumor antigen stimulation. A, Comparison of CD8+/CD4+ ratio in control and EGR2 knockout (KO) CAR T-cells after chronic CAR stimulation. B, Th…
View article: Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Comparison of Type I IFN gene expression in different CAR-T engineering approaches. (A-F) show volcano plots and a heatmap of gene expression in engineered CAR T-cells, with type I IFN genes highlighted in blue. These data represent differ…
View article: Figure S5 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S5 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Gene expression and pathway enrichment analysis of CD8+ T cell clusters. A, Heatmap showing differentially expressed genes between memory-like KLF2+ and exhausted-like MKI67+ CD8+ T-cells. Gene signature scores related to cell cycle and cl…
View article: Figure S7 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S7 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Gene expression and pathway enrichment analysis of CD4+ T cell clusters. (A) Heatmap showing differentially expressed genes between AAVS1 and EGR2 knockout (KO) CD4+ T-cells. (B-D) Top differentially regulated pathways in CD4+ EGR2 KO comp…
View article: Table S2 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Table S2 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Genes deferentially expressed in EGR2 compared to AAVS1 knockout CD8+ CAR T-cells. The corresponding log2 fold change values and statistical significance are provided for the listed genes.
View article: Figure S11 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S11 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Analysis of survival outcomes and EGR2 gene expression in CD19 CAR T-cell products. The figure presents the P values and hazard ratio of different EGR2 molecular marker stratification points in relation to A, overall survival and B, event-…
View article: Figure S7 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S7 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Gene expression and pathway enrichment analysis of CD4+ T cell clusters. (A) Heatmap showing differentially expressed genes between AAVS1 and EGR2 knockout (KO) CD4+ T-cells. (B-D) Top differentially regulated pathways in CD4+ EGR2 KO comp…
View article: Figure S9 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S9 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Epigenetic remodeling of CAR T-cells by EGR2 knockout and effect of type I IFN signaling on the development of memory and exhaustion. A, Volcano plots showing differentially accessible chromatin regions within genes between KLF2+ and MKI67…
View article: Figure S6 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S6 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Pathways regulated by EGR2 in CD8+ CAR T-cells. (A-C) Top pathways differentially expressed in EGR2 knockout CD8+ CAR-T cells compared to AAVS1 knockout CAR T-cells. Libraries used in this enrichment analysis: A, Reactome 2016. B, NCI-Natu…
View article: Table S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Table S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Chromatin accessibility profiles for EGR2 knockout (KO) and AAVS1 knockout (AAVS1) CD8+ CAR T-cells. The table provides information on the locus mapping, p-value, average log2 fold change, percentage of cells, adjusted p-value, transcript …
View article: Figure S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Impact of EGR2 knockout on different T-cell subsets and CD28-based CAR T-cells. A, Naive, central memory, effector memory, and effector T-cells were magnetically isolated. PSMA CAR-T cells with AAVS1 and EGR2 knockout (KO) were then genera…
View article: Table S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Table S3 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Chromatin accessibility profiles for EGR2 knockout (KO) and AAVS1 knockout (AAVS1) CD8+ CAR T-cells. The table provides information on the locus mapping, p-value, average log2 fold change, percentage of cells, adjusted p-value, transcript …
View article: Figure S11 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S11 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Analysis of survival outcomes and EGR2 gene expression in CD19 CAR T-cell products. The figure presents the P values and hazard ratio of different EGR2 molecular marker stratification points in relation to A, overall survival and B, event-…
View article: Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Comparison of Type I IFN gene expression in different CAR-T engineering approaches. (A-F) show volcano plots and a heatmap of gene expression in engineered CAR T-cells, with type I IFN genes highlighted in blue. These data represent differ…
View article: Table S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Table S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Genes comprising the TCF7 regulon, the type I IFN signature, and the EGR2 Co-expression signatures. Gene names and symbols are listed.
View article: Figure S9 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S9 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Epigenetic remodeling of CAR T-cells by EGR2 knockout and effect of type I IFN signaling on the development of memory and exhaustion. A, Volcano plots showing differentially accessible chromatin regions within genes between KLF2+ and MKI67…
View article: Figure S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction
Figure S1 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T cell-intrinsic Dysfunction Open
Analysis of EGR2 and type I IFN pathway regulation in CAR T-cells. (A-C) ATAC-seq tracks of genes associated with dysfunction, type I IFN signaling, and memory differentiation are shown, with differentially accessible regions indicated. D,…