Vitali Moiseenko
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View article: OCTS-09 THE PROSPECTIVE PHASE II COG-SRS TRIAL: AN UPDATE ON COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES
OCTS-09 THE PROSPECTIVE PHASE II COG-SRS TRIAL: AN UPDATE ON COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES Open
Stereotactic radiosurgery (SRS) plans that respect the neural correlates of cognition should result in better post-treatment cognitive outcomes compared to standard plans. The prospective phase II COG-SRS Trial is designed to test this hyp…
View article: RADT-50. EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RADIATION (RT)
RADT-50. EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RADIATION (RT) Open
Beyond the hippocampus, there are no evidence-based dose constraints for eloquent brain structures which subserve cognitive domains. We performed a multivariate NTCP analysis of post-RT neurocognitive decline, examining dosimetric predicto…
View article: LMAP-20 EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RT
LMAP-20 EVIDENCE-BASED MULTIVARIATE NORMAL TISSUE COMPLICATION PROBABILITY (NTCP) STUDY OF DOMAIN-SPECIFIC COGNITIVE DECLINE AFTER PARTIAL BRAIN RT Open
Beyond the hippocampus, there are no evidence-based dose constraints for eloquent structures which subserve memory and attention/processing speed. We performed a multivariate normal tissue complication probability analysis of post-RT neuro…
View article: LMAP-17 FEASIBILITY OF COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES: INITIAL REPORT OF PHASE II COG-SRS TRIAL
LMAP-17 FEASIBILITY OF COGNITIVE-SPARING STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES: INITIAL REPORT OF PHASE II COG-SRS TRIAL Open
Radiotherapy at high doses leads to white matter (WM) and hippocampal injury which can cause cognitive decline. We designed the first, to our knowledge, evidence-based cognitive-sparing brain SRS trial for patients with limited brain metas…
View article: The relationship between radiation dose and bevacizumab-related imaging abnormality in patients with brain tumors: A voxel-wise normal tissue complication probability (NTCP) analysis
The relationship between radiation dose and bevacizumab-related imaging abnormality in patients with brain tumors: A voxel-wise normal tissue complication probability (NTCP) analysis Open
Purpose Bevacizumab-related imaging abnormality (BRIA), appearing as areas of restricted diffusion on magnetic resonance imaging (MRI) and representing atypical coagulative necrosis pathologically, has been observed in patients with brain …
View article: Erratum: “Correction to stereotactic body radiation therapy: The report from the AAPM Task Group No. 101” [Med. Phys. 37(8), 4078–4101 (2010)]
Erratum: “Correction to stereotactic body radiation therapy: The report from the AAPM Task Group No. 101” [Med. Phys. 37(8), 4078–4101 (2010)] Open
Table III contained typos for three fraction constraints for parallel tissues.Specifically, threshold dose (dose per fraction) values, Gy, shown for Lung (right and left), 1500 and 1000 cc; Liver, 700 cc; and Renal cortex (right and left),…
View article: Is individual perfusion dose-response different than ventilation dose-response for lung cancer patients treated with radiotherapy?
Is individual perfusion dose-response different than ventilation dose-response for lung cancer patients treated with radiotherapy? Open
Objective: Current ventilation and perfusion dose–response studies focus on single-modalities (ventilation or perfusion) and perform pulmonary-toxicity assessment related to radiotherapy on a population-based basis. This study aims at quan…
View article: Fine Motor Skill Decline after Brain RT – A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial
Fine Motor Skill Decline after Brain RT – A Multivariate Normal Tissue Complication Probability Study of a Prospective Trial Open
Purpose Brain radiotherapy can impair fine motor skills (FMS). FMS are essential for activities of daily living, enabling hand-eye coordination for manipulative movements. We developed normal tissue complication probability (NTCP) models f…
View article: Why Do Both Mean Dose and V≥x Often Predict Normal Tissue Outcomes?
Why Do Both Mean Dose and V≥x Often Predict Normal Tissue Outcomes? Open
In the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC), High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC), and Pediatric Normal Tissue Effects in the Clinic (PENTEC) reviews, the mean d…
View article: Hypofractionated radiation therapy as palliative management for symptomatic and local control of advanced thoracic malignancies
Hypofractionated radiation therapy as palliative management for symptomatic and local control of advanced thoracic malignancies Open
Palliative SBRT has the advantage of higher biologic dose without protracted course for patients with limited prognosis. Patients showed significant symptom palliation and long-term local control. Palliative SBRT represents a reasonable tr…
View article: Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy
Evaluating predictive factors for toxicities experienced by head & neck cancer patients undergoing radiotherapy Open
Purpose The purpose of this study was to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics and dose metrics for head and neck cancer pa…
View article: Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma
Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma Open
Background Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at risk. These toxicitie…
View article: Radiotherapy Dose–Volume Effects on Salivary Gland Function
Radiotherapy Dose–Volume Effects on Salivary Gland Function Open
Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time. Severe xero…
View article: Dose-Volume Predictors of Radiation Pneumonitis After Lung Stereotactic Body Radiation Therapy (SBRT): Implications for Practice and Trial Design
Dose-Volume Predictors of Radiation Pneumonitis After Lung Stereotactic Body Radiation Therapy (SBRT): Implications for Practice and Trial Design Open
Background and purpose Recently published HyTEC report summarized lung toxicity data and proposed guidelines of mean lung dose (MLD) 20Gy<10-15% to avoid lung toxicity. Support for preferred use of a particular dosimetric parameter has bee…