Natarajan Nandakumar
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View article: Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi
Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi Open
View article: Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats
Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats Open
Background: Diabetes mellitus is among the most serious public health problems worldwide, whose incidence is steadily increasing and is now posing a global epidemic danger. Major secondary complications are associated with diabetes that im…
View article: Combination of N-acetyl Cysteine and Thymoquinone Alleviates Hepatocellular Toxicities by Radiation and CCl4 Intoxication in SD Rats
Combination of N-acetyl Cysteine and Thymoquinone Alleviates Hepatocellular Toxicities by Radiation and CCl4 Intoxication in SD Rats Open
Radiation and chemicals were the major clinical toxicants known to cause cellular damage during prognostic interventions in vivo. Cellular and molecular damages in the liver were the major causes for the hepatocellular injury due to variou…
View article: Nerolidol, bioactive compound suppress growth of HCT-116 colorectal cancer cells through cell cycle arrest and induction of apoptosis
Nerolidol, bioactive compound suppress growth of HCT-116 colorectal cancer cells through cell cycle arrest and induction of apoptosis Open
Background Colon cancer is the most prevalent cancer and causes the highest cancer-associated mortality in both men and women globally. It has a high incidence and fatality rate, which places a significant burden on the healthcare system. …
View article: Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plant<i>Bergenia ciliata</i>
Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plant<i>Bergenia ciliata</i> Open
The objective of this work was to assess the bioactive potential of endophytic fungi, Colletotrichum brevisporum (JPSK3), Pestalotiopsis microspora (JPSK19), and Guignardia mangiferae (JPSK25), from Bergenia ciliata . The antibacterial eff…
View article: Editorial: Development of novel small molecules as therapeutics for inflammatory diseases and delineating their molecular mechanisms
Editorial: Development of novel small molecules as therapeutics for inflammatory diseases and delineating their molecular mechanisms Open
EDITORIAL article Front. Pharmacol., 22 November 2022Sec. Inflammation Pharmacology Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1088908
View article: Chitosan-sodium alginate-polyethylene glycol-crocin nanocomposite treatment inhibits esophageal cancer KYSE-150 cell growth via inducing apoptotic cell death
Chitosan-sodium alginate-polyethylene glycol-crocin nanocomposite treatment inhibits esophageal cancer KYSE-150 cell growth via inducing apoptotic cell death Open
Background: Esophageal cancer is a sixth most cause of cancer-associated mortalities worldwide with increased global prevalence in each year. It has a poor prognosis with 5-year survival rate are less than 10%. Objective: The present study…
View article: Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats Open
The present findings suggested that the formulated SCPg-AI-NCs remarkably inhibited the DEN-induced liver carcinogenesis in rats. These findings provide an evidence that SCPg-AI-NCs can be a promising anticancer nano-drug in the future to …
View article: Coral-associated bacterial extracts inhibit cellular NF-κB pathway
Coral-associated bacterial extracts inhibit cellular NF-κB pathway Open
Marine natural products have recently been recognized as a promising source of NF-κB inhibitors. In this study, extracts of bacterial isolates from the coral Favis sp. were screened for NF-κB modulatory capability using an NF-κB luciferase…
View article: Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats
Chemopreventive effect of myrtenal on bacterial enzyme activity and the development of 1,2-dimethyl hydrazine-induced aberrant crypt foci in Wistar Rats Open
Colon cancer remains as a serious health problem around the world despite advances in diagnosis and treatment. Dietary fibers are considered to reduce the risk of colon cancer as they are converted to short chain fatty acids by the presenc…
View article: Exposure to polycyclic aromatic hydrocarbons with special focus on cancer
Exposure to polycyclic aromatic hydrocarbons with special focus on cancer Open
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting of two or more fused aromatic rings. Most of them are formed during incomplete combustion of organic materials such as wood and fossil fuels, petroleum products, a…