V. О. Polyakova
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View article: The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation
The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation Open
It has been previously shown that some short peptides are involved in various cellular processes, such as transcription modulation and regulation of differentiation mechanisms. In particular, the effect of peptides on the neuronal differen…
View article: The Neurotropic Activity of Novel Dermorphin Analogs Active at Systemic and Noninvasive Administration
The Neurotropic Activity of Novel Dermorphin Analogs Active at Systemic and Noninvasive Administration Open
The neuropeptide’s multifaceted involvement in various components of neural homeostasis impacts pain and behavioral regulation. One of the highly potent neuropeptides is dermorphin, extracted from the skin of the Amazon frog (Phyllomedusa …
View article: Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review)
Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review) Open
The article analyzes 50 publications devoted to diagnostic approaches to detection of sarcoidosis. It highlights that currently diagnosis of this disease is not standardized and thus errors are highly possible to occur. Improved approaches…
View article: Sagittal Parameters and Clinical Outcomes in Cervical Spondylitis: The Cohort Analysis
Sagittal Parameters and Clinical Outcomes in Cervical Spondylitis: The Cohort Analysis Open
Background. Cervical spondylitis is accompanied by segmental instability and sagittal imbalance. The purpose of this work is to conduct a search of correlation between sagittal parameters and clinical outcomes in cervical spondylitis. Mate…
View article: Factors affecting the risk of falls in people over 60 years old living in a long-term care social institution
Factors affecting the risk of falls in people over 60 years old living in a long-term care social institution Open
Introduction. The incidence of falls in people living in social institutions of long-term care and undergoing medical and social rehabilitation in a hospital setting significantly exceeds that in comparison with people living at home. The …
View article: Novel Peptidomimetic Cyclo-{E(I)-E(W)}Na (CP-88) with Hematopoietic Activity Sustained in Invasive and Oral Administration: Experimental and Preclinical Evaluation
Novel Peptidomimetic Cyclo-{E(I)-E(W)}Na (CP-88) with Hematopoietic Activity Sustained in Invasive and Oral Administration: Experimental and Preclinical Evaluation Open
Over the last decades, significant progress has been made in studying agonistic and antagonistic hematopoietic peptides. The main disadvantage of this class of peptides is their low stability with noninvasive administration methods, which …
View article: Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes
Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes Open
Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendr…
View article: Melatonin Receptors and Serotonin: Age-Related Changes in the Ovaries
Melatonin Receptors and Serotonin: Age-Related Changes in the Ovaries Open
Introduction. Melatonin and serotonin can influence certain aging processes in the ovaries. The main melatonin receptors are represented by types MT1 and MT2. The goal of investigation. Here, we evaluated the expression of genes and synthe…
View article: Collagens of placenta composition in obese puerperant women who gave birth to сhildren at St. Petersburg State Pediatric Medical University in 2018–2021
Collagens of placenta composition in obese puerperant women who gave birth to сhildren at St. Petersburg State Pediatric Medical University in 2018–2021 Open
BACKGROUND: The relevance of the problem of obesity is associated with the high frequency and steady growth of this pathology in the population. The epigenetic influence of maternal obesity on the course of pregnancy and childbirth, as wel…
View article: Endovascular Recanalization and Carotid Stenting: The New Approach to Restore Cerebral Perfusion during Aortic Dissection
Endovascular Recanalization and Carotid Stenting: The New Approach to Restore Cerebral Perfusion during Aortic Dissection Open
A type A aortic dissection (TAAD) is a dangerous condition requiring emergency surgery. Due to the similarity of the symptoms of cerebral malperfusion in TAAD and the signs of ischemic stroke, a differential diagnosis of these diseases is …
View article: Use of non-invasive mesodiencephalic brain modulation for enhancing stress resistance in athletes
Use of non-invasive mesodiencephalic brain modulation for enhancing stress resistance in athletes Open
BACKGROUND: During many years of intensive training, professional athletes may experience manifestations of stress due to significant physical and emotional stress, which require corrective measures. AIM: The aim of the study is to evaluat…
View article: The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples
The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples Open
Peptides show high promise in the targeting and intracellular delivery of next-generation biotherapeutics. The main limitation is peptides’ susceptibility to proteolysis in biological systems. Numerous strategies have been developed to ove…
View article: The molecular profile people of different ages in «normal» and with dilated cardiomyopathy
The molecular profile people of different ages in «normal» and with dilated cardiomyopathy Open
Background: Dilated cardiomyopathy (DCMP) is a cardiovascular pathology promising for consideration as a clinical model of premature aging of the body. According to the literature, sirtuins-1, 2, 3, 6; melatonin and its receptors (MT-1 and…
View article: Spectrum of Surgical Site Infection Pathogens in Chronic Infectious Spondylitis Requiring Revision Surgery: A 5-Year Cohort Study
Spectrum of Surgical Site Infection Pathogens in Chronic Infectious Spondylitis Requiring Revision Surgery: A 5-Year Cohort Study Open
Background: Spectrum monitoring of the pathogen in spondylitis patients plays a key role in preventing infectious complications of spinal reconstructions in chronic spondylitis (CS) and in the treatment of surgical site infection (SSI). Th…
View article: Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches
Melatonin levels and fetal growth restriction: Clinical insights and analytical approaches Open
Fetal growth restriction is a prevalent complication of pregnancy. Fetal growth restriction entails the pathological restriction of fetal growth, leading to heightened perinatal risks. Placental histopathology in fetal growth restriction t…
View article: The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis
The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis Open
Endometriosis is characterized by a condition where endometrial tissue grows outside the uterine cavity. The mechanisms of endometrium growth during endometriosis might be similar to the development of a tumor. The kisspeptin (KISS1) gene …
View article: Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine
Molecular Markers of Early Immune Response in Tuberculosis: Prospects of Application in Predictive Medicine Open
Tuberculosis (TB) remains an important public health problem and one of the leading causes of death. Individuals with latent tuberculosis infection (LTBI) have an increased risk of developing active TB. The problem of the diagnosis of the …
View article: Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots
Pulmonary Sarcoidosis: Experimental Models and Perspectives of Molecular Diagnostics Using Quantum Dots Open
Sarcoidosis is a complex inflammatory multisystem disease of unknown etiology that is characterised by epithelioid cell granulomatous lesions affecting various organs, mainly the lungs. In general, sarcoidosis is asymptomatic, but some cas…
View article: Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review
Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review Open
Wound healing is a complex process of overlapping phases with the primary aim of the creation of new tissues and restoring their anatomical functions. Wound dressings are fabricated to protect the wound and accelerate the healing process. …
View article: A Review on Chitosan and Cellulose Hydrogels for Wound Dressings
A Review on Chitosan and Cellulose Hydrogels for Wound Dressings Open
Wound management remains a challenging issue around the world, although a lot of wound dressing materials have been produced for the treatment of chronic and acute wounds. Wound healing is a highly dynamic and complex regulatory process th…
View article: Melatonin: Manager of psychosomatic and metabolic disorders in polymorbid cardiovascular pathology
Melatonin: Manager of psychosomatic and metabolic disorders in polymorbid cardiovascular pathology Open
Objectives To investigate the relationship between changes in circadian patterns of melatonin and clinical manifestations of polymorbid cardiovascular pathology (PCVP) in young men and to analyze the effectiveness of their complex treatmen…
View article: The Fabrication of Alginate–Carboxymethyl Cellulose-Based Composites and Drug Release Profiles
The Fabrication of Alginate–Carboxymethyl Cellulose-Based Composites and Drug Release Profiles Open
Recently, hydrogels based on natural water-soluble polysaccharides have attracted more and more attention due to their favorable characteristics. The high water-holding capacity, lack of toxicity, and biodegradability of such hydrogels mak…
View article: fMRI Findings in Cortical Brain Networks Interactions in Migraine Following Repetitive Transcranial Magnetic Stimulation
fMRI Findings in Cortical Brain Networks Interactions in Migraine Following Repetitive Transcranial Magnetic Stimulation Open
Background Repetitive transcranial magnetic stimulation (rTMS) is one of the high-potential non-pharmacological methods for migraine treatment. The purpose of this study is to define the neuroimaging markers associated with rTMS therapy in…
View article: Immunohistochemical and morphological markers of susceptibility to prolonged and postterm pregnancies
Immunohistochemical and morphological markers of susceptibility to prolonged and postterm pregnancies Open
Изучение роли маркеров NO-синтазы, CD34, коллагена и проколлагена в плаценте при тенденции к перенашиванию и переношенной беременности как клинико-морфологических и иммуногистохимических критериев диагностики и профилактики постнатальных н…
View article: Melatonin as the Cornerstone of Neuroimmunoendocrinology
Melatonin as the Cornerstone of Neuroimmunoendocrinology Open
Much attention has been recently drawn to studying melatonin – a hormone whose synthesis was first found in the epiphysis (pineal gland). This interest can be due to discovering the role of melatonin in numerous physiological processes. It…
View article: fMRI findings in cortical brain networks interactions in migraine following repetitive transcranial magnetic stimulation
fMRI findings in cortical brain networks interactions in migraine following repetitive transcranial magnetic stimulation Open
Background: Repetitive transcranial magnetic stimulation (rTMS) is one of high-potential non-pharmacological methods for migraine treatment. The purpose of this study is to objectively evaluate the efficacy of rTMS in patients with migrain…
View article: On the markers for schizophrenia
On the markers for schizophrenia Open
Summary . The study of various markers indicating an imbalance in both the neurotransmitter and immune systems observed in patients with schizophrenia is currently of great scientific and practical interest. These studies allow us to deepe…
View article: Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets
Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets Open
Sudden infant death syndrome (SIDS) is one of the primary causes of death of infants in the first year of life. According to the WHO’s data, the global infant mortality rate is 0.64–2 per 1,000 live-born children. Molecular and cellular as…
View article: Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression
Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression Open
Embryogenesis is a complex multi-stage process regulated by various signaling molecules including pineal and extrapineal melatonin (MT). Extrapineal MT is found in the placenta and ovaries, where it carries out local hormonal regulation. M…