Explanipedia

Melittin induces apoptosis, Mitochondrial membrane potential, Reactive Oxygen species, and cell cycle arrest against T-cell acute lymphoblastic leukemia (T-ALL) in vitro. Open

Ajeet Kumar, Vijai Tilak, Saraswati Raju, Akhtar Ali · 2024

Acute lymphoblastic leukemia originating from early T-cell progenitors is called T-cell acute lymphoblastic leukemia (T-ALL). Chemoresistant T-ALL cancer is gaining interest in less hazardous drugs and therapy. These days, pyrimidine and p…

Imatinib-resistant Chronic Myeloid Leukaemia Patients' BCR-ABL1 Kinase Domain Mutations in the Eastern Indian Population Open

Ajeet Kumar, Vijai Tilak, Nilesh Kumar, Akhtar Ali · 2024

Chronic myeloid leukemia is a bone marrow cancer that spreads slowly. Platelets (thrombocytes), which aid in blood clotting, white blood cells (leukocytes), which protect the body from infection, and red blood cells (erythrocytes), which s…

Histoplasmosis in Eastern Uttar Pradesh: Our five years experience at a tertiary care center Open

Ragini Tilak, Munesh Kumar Gupta, Jaya Chakravarty, Ojas Gupta, Vijai Tilak · 2023

Histoplasmosis is an endemic fungal infection which primarily infects the immunocompetent as well as immunocompromised patients. It primarily affects the respiratory tract and disseminates hematogenously where it involves the bone marrow, …

In silico analysis of genes and pathways related to acute myeloid leukemia presenting leukopenia Open

Ajeet Kumar, Ravi Bhushan, Pawan K. Dubey, Vijai Tilak, Vineeta Gupta , et al. · 2022

Acute myeloid leukemia (AML) is the progenitor and hematopoietic stem cell blood cancer. Chromosomal abnormalities include balanced translocations between two chromosomes like t[8;21] and t[15;17]) in malignant cells. The current study aim…

Philadelphia Chromosome-Positive Myelodysplastic Syndrome With Single Lineage Dysplasia Open

Ajeet Kumar, Vijai Tilak, Disha Arora, Marisha Tiwari, R. Rahul , et al. · 2022

Myelodysplastic syndrome (MDS) is a group of acquired clonal disorders characterized by dysplastic and ineffective hematopoiesis in the bone marrow. Various specific karyotypic and molecular abnormalities associated with MDS further guide …

Prevalence of von Willebrand Disease in Patients with Heavy Menstrual Bleeding: An Indian Perspective Open

Shuchi Jain, Nisha Agrawal, Vijai Tilak, Krishna S Piplani · 2022

Aim:The von Willebrand disease (vWD) is said to be the most common hemostatic disorder among the nonstructural causes of heavy menstrual bleeding (HMB).This study was carried out to find prevalence of vWD and its subtypes in patients with …

In silico analysis of genes and pathways related to acute myeloid leukemia presenting leukopenia Open

Ajeet Kumar, Ravi Bhushan, Pawan K. Dubey, Vijai Tilak, Vineeta Gupta , et al. · 2021

Acute myeloid leukemia (AML) is a type of blood cancers that begins from progenitor and hematopoietic stem cell. Chromosomal abnormalities include balanced translocations between two chromosome like t[8;21] and t[15;17]) in malignancies ce…

Clinicopathological Profile of the von Willebrand Disease in a Tertiary Care Centre in Varanasi Open

Pawan Kumar Pandey, Vijai Tilak, Mahima Yadav, Neelu Kashyap · 2021

Objective The von Willebrand disease (vWD) is one of the most common inherited bleeding disorders in India; however, the diagnostic tests and its interpretation require specialized laboratory and personnel which are not readily available i…

Indian Society of Hematology and Blood Transfusion (ISHBT) Consensus Document on Hematological Practice During COVID-19 Pandemic Open

Rakhee Kar, Tuphan Kanti Dolai, Prakash Singh Shekhawat, Pankaj Malhotra, Avinash Singh , et al. · 2021

Semi-nested polymerase chain reaction over blood culture in detection of bloodstream fungal infection in leukemic children with febrile neutropenia Open

Deepak Kumar, Pradeep Paul, Nidhi Pandey, Vineeta Gupta, Vijai Tilak , et al. · 2020

BACKGROUND: Children with hematologic malignancies are currently at a severe threat of developing bloodstream fungal infection (BSFI). The early detection of BSFI followed by appropriate management of these patients remains a challenge to …

Clinical and biochemical profile of patients with Iron deficiency anemia at a tertiary care hospital Open

Anju Bharti, Abhishek Kumar, L P Meena, Vijai Tilak · 2020

Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia worldwide, especially in adolescent girls, women of reproductive age group, and young children. The clinical presentation and the other biochemical parameters di…

Case Report: Histoplasmosis Accompanying Disseminated Tuberculosis in an Immunocompetent Adolescent Boy Open

Ashis Kumar Choudhury, Ankit Mishra, Deepak Gautam, Ragini Tilak, Vijai Tilak , et al. · 2019

The incidence of tuberculosis in India is quite high. In such a situation, empirical antitubercular therapy (ATT) is often resorted to, when some of the investigation findings are clearly diagnostic of tuberculosis. This may mean missing o…

Hemophagocytic lymphohistiocytosis– A report of three cases from Varanasi Open

Ragini Gupta, Vijai Tilak, Jaya Chakravorty · 2019

Sudan black B positive acute lymphoblastic leukemia – a case report Open

Tanima Mandal, Vijai Tilak, Dr Vineeta Gupta, Dr Priyanka Aggarwal, Dr Deepa Rani · 2019

Idiopathic Fatal Pancytopenia: A Case Report Open

Hema Goyal, Vijai Tilak · 2016

Pancytopenia is defined as decrease in red blood cells, white blood cells and platelets. Many disease processes involve the bone marrow primarily or secondarily resulting in pancytopenia. A 55-year-old male presented with generalized body …

Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia Open

Aarthi Kannan, Vijai Tilak, Madhukar Rai, Vineetha Gupta · 2016

Background: Macrocytosis is a common finding encountered in automated coulters and evaluation of clinical, biochemical and haematological parameters in macrocytic anemias will provide a clue to diagnosis. This study was done to evaluate th…

Lymphoma without Lymphadenopathy Open

Ashutosh Jain, Kailash Kumar, Mahendra Kumar Jangid, Indrajeet Singh Gambhir, Vijai Tilak · 2015

A seventy-five years old man was presented to our hospital with a complaint of gradually progressive heaviness in the left half of abdomen for past 10 months. History was negative for fever, weight loss, and night sweats. Physical examinat…

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