Juan San Martín
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View article: Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy
Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy Open
Introduction The most severe form of leishmaniasis, visceral leishmaniasis (VL), lacks standardized validated early predictors of treatment success or relapse. To distinguish between active infection and successful treatment, we searched f…
View article: <i>N</i>-[(Thiophen-3-yl)methyl]benzamides as Fusion Inhibitors of Influenza Virus Targeting H1 and H5 Hemagglutinins
<i>N</i>-[(Thiophen-3-yl)methyl]benzamides as Fusion Inhibitors of Influenza Virus Targeting H1 and H5 Hemagglutinins Open
Novel antiviral drugs are needed to prepare for infections from influenza A virus (IAV). Here, a series of N-[(thiophen-3-yl)methyl]benzamides, which target the hemagglutinin (HA)-mediated fusion process, is reported. The most active compo…
View article: <i>N</i>-[(Thiophen-3-yl)methyl]benzamides as Influenza Virus Fusion Inhibitors Acting on H1 and H5 Hemagglutinins
<i>N</i>-[(Thiophen-3-yl)methyl]benzamides as Influenza Virus Fusion Inhibitors Acting on H1 and H5 Hemagglutinins Open
Novel antiviral drugs are needed to prepare against infections from influenza A virus (IAV). Here a series of N -[(thiophen-3-yl)methylbenzamides which target the hemagglutinin (HA)-mediated fusion process is reported. The most active comp…
View article: AI Predictive Model of Mortality and Intensive Care Unit Admission in the COVID-19 Pandemic: Retrospective Population Cohort Study of 12,000 Patients
AI Predictive Model of Mortality and Intensive Care Unit Admission in the COVID-19 Pandemic: Retrospective Population Cohort Study of 12,000 Patients Open
Background One of the main challenges with COVID-19 has been that although there are known factors associated with a worse prognosis, clinicians have been unable to predict which patients, with similar risk factors, will die or require int…
View article: A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses Open
The approval of COVID-19 vaccines and antiviral drugs has been crucial to end the global health crisis caused by SARS-CoV-2. However, to prepare for future outbreaks from drug-resistant variants and novel zoonotic coronaviruses (CoVs), add…
View article: Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria
Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria Open
Background: Five fulfilled hemophagocytic lymphohistiocytosis (HLH)‐2004 criteria, and the HScore are widely used and recommended by international expert consensus to diagnose secondary HLH. Both diagnostic scores have never been validated…
View article: Health outcomes of COVID-19 in immigrants versus native Spaniards
Health outcomes of COVID-19 in immigrants versus native Spaniards Open
Elevated infection rates in immigrants, particularly Latin Americans, likely explain their higher hospitalization and ICU admission rates. Mortality, adjusted for demographics and clinical factors, did not differ significantly. Future rese…
View article: Assessment of Chemical and Biological Fungicides for the Control of Diplodia mutila Causing Wood Necrosis in Hazelnut
Assessment of Chemical and Biological Fungicides for the Control of Diplodia mutila Causing Wood Necrosis in Hazelnut Open
Fungal trunk disease (FTD) poses a significant threat to hazelnut (Corylus avellana L.) production worldwide. In Chile, the fungus Diplodia mutila, from the Botryosphaeriaceae family, has been frequently identified causing this disease in …
View article: A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses Open
The approval of COVID-19 vaccines and antiviral drugs has been crucial to end the global health crisis caused by SARS-CoV-2. However, to prepare for future outbreaks from drug-resistant variants and novel zoonotic coronaviruses (CoVs), add…
View article: Assessment of Chemical and Biological Fungicides for the Control of Diplodia mutila Causing Wood Necrosis in Hazelnut
Assessment of Chemical and Biological Fungicides for the Control of Diplodia mutila Causing Wood Necrosis in Hazelnut Open
Fungal trunk disease (FTD) poses a significant threat to hazelnut (Corylus avellana L.) production worldwide. In Chile, the fungus Diplodia mutila, from the Botryosphaeriaceae family, has been frequently identified causing this disease in …
View article: Use of Pseudomonas protegens to Control Root Rot Disease Caused by Boeremia exigua var. exigua in Industrial Chicory (Cichorium intybus var. sativum Bisch.)
Use of Pseudomonas protegens to Control Root Rot Disease Caused by Boeremia exigua var. exigua in Industrial Chicory (Cichorium intybus var. sativum Bisch.) Open
Boeremia exigua var. exigua is a recurrent pathogen causing root rot in industrial chicory. Currently, there is no chemical or varietal control for this disease, and thus, management strategies need to be developed. This study determined t…
View article: Use of <em>Pseudomonas protegens </em>to Control Root Rot Disease Caused by <em>Boeremia exigua</em> var. <em>exigua </em>in Industrial Chicory (<em>Cichorium intybus</em> var. <em>sativum</em> Bisch.)
Use of <em>Pseudomonas protegens </em>to Control Root Rot Disease Caused by <em>Boeremia exigua</em> var. <em>exigua </em>in Industrial Chicory (<em>Cichorium intybus</em> var. <em>sativum</em> Bisch.) Open
Boeremia exigua var. exigua is a recurrent pathogen causing root rot in industrial chicory. Currently, there is no chemical or varietal control for this disease, and thus management strategies need to be developed. This study determined th…
View article: Seven Epidemic Waves of COVID-19 in a Hospital in Madrid: Analysis of Severity and Associated Factors
Seven Epidemic Waves of COVID-19 in a Hospital in Madrid: Analysis of Severity and Associated Factors Open
(1) Background: COVID-19 has evolved during seven epidemic waves in Spain. Our objective was to describe changes in mortality and severity in our hospitalized patients. (2) Method: This study employed a descriptive, retrospective approach …
View article: Seven Epidemic Waves of COVID-19 in a Hospital in Madrid. Analysis of Severity and Associated Factors
Seven Epidemic Waves of COVID-19 in a Hospital in Madrid. Analysis of Severity and Associated Factors Open
(1) Background: Since the onset of the SARS-CoV-2 pandemic, seven epidemic waves have been described in Spain. Our objective was to study mortality and severity, and associated factors in our hospitalized patients; (2) Method: Retrospectiv…
View article: Anatomy of a high-silica eruption as observed by a local seismic network: the June 2011 Puyehue–Cordón Caulle event (southern Andes, Chile)
Anatomy of a high-silica eruption as observed by a local seismic network: the June 2011 Puyehue–Cordón Caulle event (southern Andes, Chile) Open
High-silica explosive eruptions are one of the most dangerous natural phenomena, yet it is unclear which processes are involved in this infrequent kind of event. We present the first systematic characterization of near-field seismicity ass…
View article: Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants
Comparative Study of Vaccinated and Unvaccinated Hospitalised Patients: A Retrospective Population Study of 500 Hospitalised Patients with SARS-CoV-2 Infection in a Spanish Population of 220,000 Inhabitants Open
Objectives. This study aimed to compare the characteristics of fully and partially vaccinated or unvaccinated coronavirus disease 2019 (COVID-19) patients who were hospitalised in a population of 220,000 habitants. Methods: Retrospective, …
View article: Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells)
Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells) Open
Our research group has been developing a series of biological drugs produced by coculture techniques with M2-polarized macrophages with different primary tissue cells and/or mesenchymal stromal cells (MSC), generally from fat, to produce a…
View article: Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM)
Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM) Open
Intercellular communication between monocytes/macrophages and cells involved in tissue regeneration, such as mesenchymal stromal cells (MSCs) and primary tissue cells, is essential for tissue regeneration and recovery of homeostasis. Typic…
View article: Prognostic factors and combined use of tocilizumab and corticosteroids in a Spanish cohort of elderly COVID‐19 patients
Prognostic factors and combined use of tocilizumab and corticosteroids in a Spanish cohort of elderly COVID‐19 patients Open
Coronavirus disease 2019 (COVID‐19) infection in elderly patients is more aggressive and treatments have shown limited efficacy. Our objective is to describe the clinical course and to analyze the prognostic factors associated with a highe…
View article: Leishmaniasis: A new method for confirming cure and detecting asymptomatic infection in patients receiving immunosuppressive treatment for autoimmune disease
Leishmaniasis: A new method for confirming cure and detecting asymptomatic infection in patients receiving immunosuppressive treatment for autoimmune disease Open
Visceral leishmaniasis (VL) in patients receiving immunosuppressant drugs for autoimmune disease has been on the rise. It is important—but difficult—to know when cure has been achieved in these patients since the withdrawal of immunosuppre…
View article: Role of asymptomatic and symptomatic humans as reservoirs of visceral leishmaniasis in a Mediterranean context
Role of asymptomatic and symptomatic humans as reservoirs of visceral leishmaniasis in a Mediterranean context Open
There is no consensus amongst authors on the definition of an 'asymptomatic case' nor on the tools for screening; we, therefore, have adopted one for the sake of clarity. Immunocompetent subjects, both infected asymptomatics and those trea…
View article: Processes culminating in the 2015 phreatic explosion at Lascar volcano, Chile, evidenced by multiparametric data
Processes culminating in the 2015 phreatic explosion at Lascar volcano, Chile, evidenced by multiparametric data Open
Small steam-driven volcanic explosions are common at volcanoes worldwide but are rarely documented or monitored; therefore, these events still put residents and tourists at risk every year. Steam-driven explosions also occur frequently (on…