Satish S.C. Rao
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View article: Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study
Efficacy and safety of Cyperus rotundus extract on weight management in obese individuals: A randomized, double-blind, placebo-controlled study Open
Background: Obesity, a critical public health issue, is linked to numerous metabolic and cardiovascular disorders. Natural products may present a safer and more holistic approach to weight management. A standardized extract of Cyperus rotu…
View article: Estimation of salivary protectin D1 in periodontitis patients with metabolic syndrome following non-surgical periodontal therapy
Estimation of salivary protectin D1 in periodontitis patients with metabolic syndrome following non-surgical periodontal therapy Open
Objectives This study aims to assess periodontal and biochemical parameters and evaluate the salivary Protectin D1 levels in periodontitis patients with and without metabolic syndrome after non-surgical periodontal therapy. Materials and m…
View article: Real-World Evidence of the Long-Term Clinical Utility of a Vibrating Capsule in the Management of Chronic Idiopathic Constipation
Real-World Evidence of the Long-Term Clinical Utility of a Vibrating Capsule in the Management of Chronic Idiopathic Constipation Open
INTRODUCTION: Pharmacological therapies for chronic idiopathic constipation (CIC) are useful, but many patients report dissatisfaction from a lack of efficacy and occurrence of adverse events. The vibrating capsule (VC) is a US Food and Dr…
View article: Postpartum Anorectal and Pelvic Floor Disorders: Evaluation, Treatment, and Prevention
Postpartum Anorectal and Pelvic Floor Disorders: Evaluation, Treatment, and Prevention Open
Purpose of Review Postpartum anorectal and pelvic floor disorders (PFD) are common, though under-recognized. There is limited knowledge regarding their diagnosis, treatment, and prevention. Here we provide a critical review of this topic a…
View article: Development and Validation of a Bowel Diary for Fecal Incontinence: Comparison With a Questionnaire
Development and Validation of a Bowel Diary for Fecal Incontinence: Comparison With a Questionnaire Open
Background and Aims Bowel diaries are used to characterize the severity of fecal incontinence (FI) but have not been adequately validated for this purpose. Our aims were to validate a new bowel diary and to compare the characteristics of F…
View article: Artificial Intelligence Model for Time Series Classification: Prediction of Delayed Balloon Expulsion Test Using High‐Resolution Anorectal Manometry Data and Time‐Series Integrated Pressurized Volume
Artificial Intelligence Model for Time Series Classification: Prediction of Delayed Balloon Expulsion Test Using High‐Resolution Anorectal Manometry Data and Time‐Series Integrated Pressurized Volume Open
Background We previously demonstrated the novel concept of using the integrated pressurized volume (IPV) with high‐resolution anorectal manometry (HRAM) and found that it was predictive of delayed balloon expulsion (BE) test results. Howev…
View article: Bidirectional endoscopic and pharmacological approach for the treatment of severe right-sided colonic stool impaction
Bidirectional endoscopic and pharmacological approach for the treatment of severe right-sided colonic stool impaction Open
A female patient in her 40s with scleroderma and Behçet’s disease presented with dehydration, weight loss, fever and stool impaction. She failed aggressive laxatives and rectal enemas and was referred for colectomy. Abdominal X-ray reveale…
View article: The Vibrating Capsule: Safety and Tolerability in Patients With Chronic Idiopathic Constipation
The Vibrating Capsule: Safety and Tolerability in Patients With Chronic Idiopathic Constipation Open
Background Chronic idiopathic constipation (CIC) remains a significant problem globally with increasing estimates for disease burden. In a Phase 3 placebo‐controlled trial, a novel treatment using the Vibrating Capsule was recently shown t…
View article: Impact of Constipation Therapies on Severity of Gastroparesis and Constipation Symptoms in Relation to Gastric and Colonic Transit
Impact of Constipation Therapies on Severity of Gastroparesis and Constipation Symptoms in Relation to Gastric and Colonic Transit Open
Introduction Studies demonstrate an overlap of constipation with gastroparesis and functional dyspepsia, but the impact of treatments that target constipation on improving upper gastrointestinal (UGI) symptoms is unexplored. We quantified …
View article: The Assessment of Gastrointestinal Transit by the Atmo Capsule: A Comparison With the SmartPill Capsule
The Assessment of Gastrointestinal Transit by the Atmo Capsule: A Comparison With the SmartPill Capsule Open
gov number, NCT05718505.
View article: Disaccharidase Enzyme Deficiency in Adult Patients With Gas and Bloating
Disaccharidase Enzyme Deficiency in Adult Patients With Gas and Bloating Open
INTRODUCTION: Disaccharidases produced by the small intestinal brush border facilitate digestion of dietary carbohydrates. If deficient, they can cause carbohydrate malabsorption, resulting in several abdominal symptoms. Our aim was to exa…
View article: Clinical trial: Effects of treatment with a vibrating capsule in patients with severe chronic constipation
Clinical trial: Effects of treatment with a vibrating capsule in patients with severe chronic constipation Open
Summary Background There is little information on the effectiveness of therapies for severe chronic constipation. In a phase 3 trial, we previously demonstrated that a vibrating capsule was significantly more efficacious than a placebo in …
View article: The role of a social determinants of health summary measure on the association between cancer history status and colorectal cancer screening utilization among screening eligible adults
The role of a social determinants of health summary measure on the association between cancer history status and colorectal cancer screening utilization among screening eligible adults Open
A personal history of cancer was associated with greater utilization of CRC screening, whilst having at least one social need had lower screening use. Having social needs plays an important role in reducing screening uptake among adults wi…
View article: Predicting Response to Neuromodulators or Prokinetics in Patients With Suspected Gastroparesis Using Machine Learning: The “BMI, Infectious Prodrome, Delayed GES, and No Diabetes” Model
Predicting Response to Neuromodulators or Prokinetics in Patients With Suspected Gastroparesis Using Machine Learning: The “BMI, Infectious Prodrome, Delayed GES, and No Diabetes” Model Open
INTRODUCTION: Pharmacologic therapies for symptoms of gastroparesis (GP) have limited efficacy, and it is difficult to predict which patients will respond. In this study, we implemented a machine learning model to predict the response to p…
View article: The Vibrating Capsule- Safety and Tolerability in Patients with Chronic Idiopathic Constipation
The Vibrating Capsule- Safety and Tolerability in Patients with Chronic Idiopathic Constipation Open
BACKGROUND Chronic Idiopathic Constipation (CIC) remains a significant problem globally with increasing estimates for disease burden. The Vibrating Capsule was recently shown in a Phase 3 Placebo-Controlled Trial to be effective in treatin…
View article: Accuracy of patient‐reported bowel symptoms for fecal incontinence: Historical recall versus prospective evaluation
Accuracy of patient‐reported bowel symptoms for fecal incontinence: Historical recall versus prospective evaluation Open
Introduction Fecal incontinence (FI) is characterized by both irregular and unpredictable bowel symptoms. An accurate history of symptoms is important for diagnosis and guiding management. Whether a patient's history of bowel symptoms is r…
View article: Pathoetiology of Levator Ani Syndrome and Its Treatment With Translumbosacral Neuromodulation Therapy
Pathoetiology of Levator Ani Syndrome and Its Treatment With Translumbosacral Neuromodulation Therapy Open
INTRODUCTION: The pathoetiology and treatment of levator ani syndrome (LAS) remain unclear. METHODS: We evaluated pathophysiology using translumbosacral motor-evoked potentials and anorectal manometry in patients with LAS and compared with…
View article: Influence of Demographic Factors on Clinical Outcomes in Adults With Chronic Idiopathic Constipation Treated With Plecanatide
Influence of Demographic Factors on Clinical Outcomes in Adults With Chronic Idiopathic Constipation Treated With Plecanatide Open
INTRODUCTION: Chronic idiopathic constipation (CIC) is a common condition that affects some patient groups more often. Demographic/clinical characteristics can differ in presentation and therapeutic response. The impact of these characteri…
View article: Editorial: faecal incontinence is prevalent in IBS, as are effective treatment options!
Editorial: faecal incontinence is prevalent in IBS, as are effective treatment options! Open
LINKED CONTENT This article is linked to Goodoory et al papers. To view these articles, visit https://doi.org/10.1111/apt.17465 and https://doi.org/10.1111/apt.17494 .
View article: Thoracic Spinal Nerve Neuromodulation Therapy for Diabetic Gastroparesis: A Proof-of-Concept Study
Thoracic Spinal Nerve Neuromodulation Therapy for Diabetic Gastroparesis: A Proof-of-Concept Study Open
Diabetic gastroparesis (DGp) is associated with severe symptoms, impaired quality of life, and significant health care utilization.1Sharma A. et al.Curr Gastroenterol Rep. 2020; 22: 1-10Crossref Scopus (7) Google Scholar Treatment of DGp r…
View article: Dr. Jeffrey L. Conklin memoriam
Dr. Jeffrey L. Conklin memoriam Open
Dr. Jeffrey L. Conklin was born in Iowa City, Iowa, on February 20, 1950, the state in which he spent his formative years. He completed his undergraduate studies at the University of Iowa with a Bachelor of Science degree in journalism tha…
View article: Sucrose intolerance in adults with common functional gastrointestinal symptoms
Sucrose intolerance in adults with common functional gastrointestinal symptoms Open
Sucrose intolerance is a form of carbohydrate malabsorption caused by sucrase-isomaltase deficiency that is more common than recognized. Its symptoms include postprandial cramping, bloating, gas, and diarrhea, which are difficult to distin…