V. Siddartha Yerramilli
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View article: Role of Dynamin 2 in mitochondrial fission and cell cycle regulation:<i>Dysregulation of a miR-124-3p-STAT3-DNM2-Drp1-RGCC pathway connects fission and cell proliferation in pulmonary arterial hypertension</i>
Role of Dynamin 2 in mitochondrial fission and cell cycle regulation:<i>Dysregulation of a miR-124-3p-STAT3-DNM2-Drp1-RGCC pathway connects fission and cell proliferation in pulmonary arterial hypertension</i> Open
Introduction Dynamin-related protein 1 (Drp1) activation increases mitochondrial fission and cell cycle progression in hyperproliferative cells, termed mitotic fission . However, the diameter of a fission apparatus comprised solely of Drp1…
View article: The scaffolding protein IQGAP1 enhances EGFR signaling by promoting oligomerization and preventing degradation
The scaffolding protein IQGAP1 enhances EGFR signaling by promoting oligomerization and preventing degradation Open
IQGAP1 is a large, multi-domain scaffold that connects and modulates different signaling networks including the one initiated by epidermal growth factor (EGF). In this study, we have used live cell fluorescence imaging methods along with o…
View article: Human ESCRT-I and ALIX function as scaffolding helical filaments<i>in vivo</i>
Human ESCRT-I and ALIX function as scaffolding helical filaments<i>in vivo</i> Open
Summary The Endosomal Sorting Complex Required for Transport (ESCRT) is an evolutionarily conserved machinery that performs reverse-topology membrane scission in cells universally required from cytokinesis to budding of enveloped viruses. …
View article: IQGAP1 enhances EGFR signaling by Promoting Oligomerization and Preventing Degradation
IQGAP1 enhances EGFR signaling by Promoting Oligomerization and Preventing Degradation Open
IQGAP1 is a large, multi-domain scaffold that connects and modulates different signaling networks including the one initiated by epidermal growth factor (EGF)by localizing and concentrating pathway components to promote activation. In this…
View article: IQGAP1 scaffolding links phosphoinositide kinases to cytoskeletal reorganization
IQGAP1 scaffolding links phosphoinositide kinases to cytoskeletal reorganization Open
View article: Design of a Rapid and Reversible Fluorescence Assay to Detect Covid-19 and other Pathogens
Design of a Rapid and Reversible Fluorescence Assay to Detect Covid-19 and other Pathogens Open
We describe a rapid and reusable biophysical method to assay COVID-19. The method uses fluorescent sensors (i.e., molecular beacons) designed to detect a specific RNA sequence from COVID-19 but is general to any RNA of interest. The assay …
View article: Design Of A Rapid And Reversible Fluorescence Assay To Detect Covid-19 And Other Pathogens
Design Of A Rapid And Reversible Fluorescence Assay To Detect Covid-19 And Other Pathogens Open
We describe a rapid and reusable biophysical method to assay COVID-19 and other pathogens. The method uses fluorescent sensors (i.e. molecular beacons) designed to detect COVID-19 RNA or any RNA of interest, concurrent with an internal con…
View article: The Gαq/phospholipase Cβ signaling system represses tau aggregation
The Gαq/phospholipase Cβ signaling system represses tau aggregation Open
View article: IQGAP1 Scaffolding Connects EGFR and Phosphoinositide Signaling to Cytoskeletal Reorganization
IQGAP1 Scaffolding Connects EGFR and Phosphoinositide Signaling to Cytoskeletal Reorganization Open
View article: IQGAP1 connects phosphoinositide signaling to cytoskeletal reorganization
IQGAP1 connects phosphoinositide signaling to cytoskeletal reorganization Open
IQGAP1 is a multi-domain protein that acts as a scaffold for multiple signaling pathways. IQGAP1 generates the lipid messenger PI(3,4,5)P 3 by scaffolding the phosphoinositide kinases PIPKIs and PI3K. The dynamics of this scaffolding prote…
View article: Labeling RNAs in live cells using malachite green aptamer scaffolds as fluorescent probes
Labeling RNAs in live cells using malachite green aptamer scaffolds as fluorescent probes Open
RNAs mediate many different processes that are central to cellular function. The ability to quantify or image RNAs in live cells is very useful in elucidating such functions of RNA. RNA aptamerfluorogen systems have been increasingly used …
View article: Context-Dependent Genetic Regulation
Context-Dependent Genetic Regulation Open
Cells process extra-cellular signals with multiple layers of complex biological networks. Due to the stochastic nature of the networks, the signals become significantly noisy within the cells and in addition, due to the nonlinear nature of…
View article: HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding
HIV-1 Nucleocapsid Mimics the Membrane Adaptor Syntenin PDZ to Gain Access to ESCRTs and Promote Virus Budding Open
View article: The breast cancer susceptibility gene product (γ-synuclein) alters cell behavior through it interaction with phospholipase Cβ
The breast cancer susceptibility gene product (γ-synuclein) alters cell behavior through it interaction with phospholipase Cβ Open