Valentina Vaira
YOU?
Author Swipe
View article: Chromatin remodeling restrains oncogenic functions in prostate cancer
Chromatin remodeling restrains oncogenic functions in prostate cancer Open
View article: Lipidome profile of cystic fibrosis-related diabetes, type 1 and type 2 diabetes mellitus: potential links to inflammation and glucose and lipid metabolism
Lipidome profile of cystic fibrosis-related diabetes, type 1 and type 2 diabetes mellitus: potential links to inflammation and glucose and lipid metabolism Open
CFRD is characterized by altered lipid metabolism, insulin deficiency, and insulin resistance, which are distinctive features that partially overlap with both T1DM and T2DM. Systemic inflammation with elevated free FA and reduced plasma li…
View article: Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study
Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study Open
View article: V-ATPase in glioma stem cells: a novel metabolic vulnerability
V-ATPase in glioma stem cells: a novel metabolic vulnerability Open
Background Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. Here we studied how pa…
View article: Preclinical Evaluation of the Antitumoral Efficacy of Wee1 Inhibitor Azd1775 in Adrenocortical Carcinoma
Preclinical Evaluation of the Antitumoral Efficacy of Wee1 Inhibitor Azd1775 in Adrenocortical Carcinoma Open
View article: MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity Open
Metastasis to vital organs remains the leading cause of cancer-related deaths, emphasizing an urgent need for actionable targets in advanced-stage cancer. The role of mitochondrial Rho GTPase 2 (MIRO2) in prostate cancer growth was recentl…
View article: Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors
Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors Open
RASSF1A and APC promoter methylation is a hallmark of parathyroid tumors; deregulation of DNMTs activity contributes to modulation of RASSF1A expression. Loss of RASSF1A may be involved in the tuning of ERK pathway in parathyroid tumors.
View article: Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors
Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors Open
Purpose: Aberrant epigenetic features are key events involved in parathyroid tumorigenesis, including DNA methylation, histone methylation, and non-coding RNAs. Ras Association Domain Family Protein1 Isoform A (RASSF1A) and Adenomatous Pol…
View article: Chromatin remodeling restraints oncogenic functions in prostate cancer
Chromatin remodeling restraints oncogenic functions in prostate cancer Open
Primary prostate cancer (PCa) is characterized by multifocal growth and a highly variable clinical course, which is not effectively predicted by prognostic screenings. Innovative strategies for the stratification of primary prostate cancer…
View article: Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S6 includes scRNA-seq data showing that Luminal (high Ly6d) cells in MYC-transformed DLP display glycolytic features.
View article: Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S5 shows the output of ESTIMATE and PUREE methods to assess tumor purity.
View article: Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S6 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S6 includes scRNA-seq data showing that Luminal (high Ly6d) cells in MYC-transformed DLP display glycolytic features.
View article: Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S3 shows a graphical representation of key metabolic pathways altered by MYC alone or by obesogenic HFD in WT and MYC-transformed DLP.
View article: Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S7 shows the output of mouse-based deconvolution models ImmuCC and mMCP.
View article: Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S2 shows the effect of obesogenic HFD on AP and VP lobes, the effect of HFD on cell proliferation rate in MYC-transformed DLP, and the effect of HFD on WT prostate lobes.
View article: Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S7 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S7 shows the output of mouse-based deconvolution models ImmuCC and mMCP.
View article: Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Excel file containing 19 supplementary tables
View article: Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S5 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S5 shows the output of ESTIMATE and PUREE methods to assess tumor purity.
View article: Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S9 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S9 shows GSEA_Hallmark results in human PCa
View article: Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S1 shows the systemic effects of HFD.
View article: Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S4 shows the effect of obesogenic high-fat diet on glycolytic enzymes and HIF-1 alpha in vivo.
View article: Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S1 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S1 shows the systemic effects of HFD.
View article: Supplementary Figure S8 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S8 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S8 shows migration assays of MYC-CaP cells treated with lactate or LDHA inhibitor FX11.
View article: Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S2 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S2 shows the effect of obesogenic HFD on AP and VP lobes, the effect of HFD on cell proliferation rate in MYC-transformed DLP, and the effect of HFD on WT prostate lobes.
View article: Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S3 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S3 shows a graphical representation of key metabolic pathways altered by MYC alone or by obesogenic HFD in WT and MYC-transformed DLP.
View article: Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary references for Materials and Methods
View article: Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Tables S1-S19 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Excel file containing 19 supplementary tables
View article: Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Information from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary references for Materials and Methods
View article: Supplementary Figure S10 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S10 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S10 shows the output of human-based deconvolution model QuanTIseq.
View article: Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Supplementary Figure S4 from Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer Open
Supplementary Figure S4 shows the effect of obesogenic high-fat diet on glycolytic enzymes and HIF-1 alpha in vivo.