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View article: Antigen dependency delineates memory and exhausted CD8 T cells 4050
Antigen dependency delineates memory and exhausted CD8 T cells 4050 Open
Description Antigen experienced T cell subsets are heterogenous, and can be described based on their phenotype, function, and migration properties. Whether antigen stimulation regulates the migration, survival, differentiation, or developm…
View article: Elucidating the cellular and molecular basis of anti-tumor peptide alarm therapy 4568
Elucidating the cellular and molecular basis of anti-tumor peptide alarm therapy 4568 Open
Description After viral infection, non-circulating antigen-specific CD8+ T cells are stably maintained at sites of infection, primed for rapid response to re-infection. Immunosurveillance by these memory T cells is evident across multiple …
View article: Early exposure to frequent microbial infections prevents both spontaneous and immune checkpoint inhibitor-induced autoimmune diabetes 4408
Early exposure to frequent microbial infections prevents both spontaneous and immune checkpoint inhibitor-induced autoimmune diabetes 4408 Open
Description It has been difficult to study contextually how infections may trigger or prevent autoimmune diabetes because diabetes mouse models are kept in specific pathogen-free (SPF) environments, which do not accurately correlate to an …
View article: Iterative stimulation generates exhaustion resistant T cells 3147
Iterative stimulation generates exhaustion resistant T cells 3147 Open
Description It is currently unclear whether T cell exhaustion can be avoided or is an axiomatic product of chronic antigen stimulation. Recently we have demonstrated that memory CD8 T cells are capable of mounting highly functional antigen…
View article: Humanized DRAGA mice are a valuable model to study novel immunotherapies for HIV-1
Humanized DRAGA mice are a valuable model to study novel immunotherapies for HIV-1 Open
Humanized (h) DRAGA mice are a promising in vivo model for investigating immunotherapies for treating HIV infections. These mice are not only susceptible to HIV infection, but they also develop functional human immune cells, including T ce…
View article: Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease
Chronic Intestinal Inflammation and Microbial Dysbiosis Are Associated With Female Reproductive Outcomes in a Mouse Model of Inflammatory Bowel Disease Open
Chronic bowel inflammation induces gut dysbiosis and likely contributes to adverse reproductive outcomes through endocrine imbalances. Further investigation with human studies is needed.
View article: Human-immune-system humanized-DRAGA mice are a valuable model to study novel immunotherapies for HIV-1
Human-immune-system humanized-DRAGA mice are a valuable model to study novel immunotherapies for HIV-1 Open
Humanized (h)DRAGA mice are a promising in vivo model for investigating immunotherapies for treating HIV infections. These mice are not only susceptible to HIV infection, but they also develop functional human immune cells, including T cel…
View article: Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
Conserved epigenetic hallmarks of T cell aging during immunity and malignancy Open
Chronological aging correlates with epigenetic modifications at specific loci, calibrated to species lifespan. Such ‘epigenetic clocks’ appear conserved among mammals, but whether they are cell autonomous and restricted by maximal organism…
View article: Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses
Cutting Edge: First Lung Infection Permanently Enlarges Lymph Nodes and Enhances New T Cell Responses Open
Humans experience frequent respiratory infections. Immunology and vaccinology studies in mice are typically performed in naive specific pathogen-free animals responding to their very first respiratory challenge. We found that the first res…
View article: Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues
Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues Open
T cells are required to clear infection, and T cell motion plays a role in how quickly a T cell finds its target, from initial naive T cell activation by a dendritic cell to interaction with target cells in infected tissue. To better under…
View article: Author response: Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues
Author response: Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract T cells…
View article: Chronic antigen in solid tumors drives a distinct program of T cell residence
Chronic antigen in solid tumors drives a distinct program of T cell residence Open
Analyses of healthy tissue reveal signatures that identify resident memory CD8 + T cells (T RM ), which survey tissues without recirculating. The density of T RM phenotype cells within solid tumors correlates favorably with prognosis, sugg…
View article: Defining the abundance, fate, and function of secondary lymphoid organ resident memory T cells
Defining the abundance, fate, and function of secondary lymphoid organ resident memory T cells Open
For sixty years we have understood that lymphocytes recirculate through blood and secondary lymphoid organs (SLO). Recently, it has been observed that SLOs contain resident populations of memory T cells. Here, we show that conventional iso…
View article: C57BL/6 mice cohoused with pet shop mice phenocopy immune-related adverse events associated with checkpoint inhibition
C57BL/6 mice cohoused with pet shop mice phenocopy immune-related adverse events associated with checkpoint inhibition Open
Checkpoint inhibition has been successful in the treatment of a number of malignancies. These medications block inhibitory pathways in T cells and allow for their improved function in anti-tumor immune responses. An important factor limiti…
View article: Precise activation of antiviral memory T cells in solid tumors triggers a multi-cytokine response that ultimately drives tumor clearance
Precise activation of antiviral memory T cells in solid tumors triggers a multi-cytokine response that ultimately drives tumor clearance Open
The reactivation of CD8+ tissue-resident memory T cells (TRM) triggers a broad, yet local response that mobilizes adaptive and innate immune cells. This immunostimulatory process can be initiated in solid tumors when infiltrating antiviral…
View article: Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa Open
The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues and mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop …
View article: Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Open
Respiratory tract resident memory T cells (T RM ), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes r…
View article: Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues
Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues Open
T cells are required to clear infection, moving first in lymph nodes to interact with antigen bearing dendritic cells leading to activation. T cells then move to sites of infection to find and clear infection. T cell motion plays a role in…
View article: Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803
Transient T Cell Expansion, Activation, and Proliferation in Therapeutically Vaccinated Simian Immunodeficiency Virus-Positive Macaques Treated with N-803 Open
While antiretroviral therapy (ART) can suppress HIV replication, it is not a cure. It is therefore essential to develop therapeutic strategies to enhance the immune system to better become activated and recognize virus-infected cells.
View article: 1027 Chronic antigen in solid tumors drives a distinct program of T cell residence
1027 Chronic antigen in solid tumors drives a distinct program of T cell residence Open
Background Resident-memory T cells (TRM) permanently reside in tissues, surveying local environments without recirculating. Surface protein expression (e.g. CD69, CD103) and transcriptional signatures from infection models are used as surr…
View article: Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia
Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia Open
Lymphocytic choriomeningitis virus (LCMV) is the prototypic arenavirus and a natural mouse pathogen. LCMV-Armstrong, an acutely resolved strain, and LCMV-clone 13, a mutant that establishes chronic infection, have provided contrasting infe…
View article: Transient T cell expansion, activation, and proliferation in therapeutically vaccinated SIV+ macaques treated with N-803
Transient T cell expansion, activation, and proliferation in therapeutically vaccinated SIV+ macaques treated with N-803 Open
Vaccine strategies aimed at eliciting HIV-specific CD8+ T cells are one major target of interest in HIV functional cure strategies. We hypothesized that CD8+ T cells elicited by therapeutic vaccination during antiretroviral therapy (ART) w…
View article: Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells
Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Open
Respiratory tract resident memory T cells (Trm), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes res…
View article: Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity
Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing Abs target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns have arise…
View article: Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity
Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing antibodies target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns hav…