V. Bansal
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View article: Scalable and accurate rare variant meta-analysis with Meta-SAIGE
Scalable and accurate rare variant meta-analysis with Meta-SAIGE Open
Meta-analysis enhances the power of rare variant association tests by combining summary statistics across several cohorts. However, existing methods often fail to control type I error for low-prevalence binary traits and are computationall…
View article: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors
Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors Open
The procognitive growth factor erythropoietin (EPO) and its canonical receptor, EPOR, have long been recognized to be expressed by most cell types in the brain. Cognitive domains, improved by injections of exogenous EPO or by endogenous, h…
View article: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors
Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors Open
The procognitive growth factor erythropoietin (EPO) and its canonical receptor, EPOR, have long been recognized to be expressed by most cell types in the brain. Cognitive domains, improved by injections of exogenous EPO or by endogenous, h…
View article: Unveiling the potential of macroalgae <i>Porphyra</i> sp. (nori) in food, pharmaceutics and health sector
Unveiling the potential of macroalgae <i>Porphyra</i> sp. (nori) in food, pharmaceutics and health sector Open
Porphyra sp. (nori), a species of red seaweed, has garnered attention for its rich nutritional profile and diverse bioactive compounds. This review synthesizes current research on Porphyra nori, focusing on its composition, bioactive compo…
View article: Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis
Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis Open
BACKGROUND Pulmonary hypertension (PH) is a progressive disease characterized by endothelial dysfunction and vascular remodeling and is a leading cause of mortality worldwide. Although it is independently associated with multiple comorbidi…
View article: Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease
Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease Open
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from a small cohort of …
View article: A critical review on <i>Moringa oleifera</i> : current status, physicochemical attributes, and food industrial applications
A critical review on <i>Moringa oleifera</i> : current status, physicochemical attributes, and food industrial applications Open
Phytomedicine as an alternative to conventional medications which become more interested for researcher. Moringa Oleifera (M. Oleifera) has been used for centuries to cure a range of illnesses. M. Oleifera, commonly known as the miracle tr…
View article: Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutation
Single-cell transcriptomic changes in oligodendroglial lineage cells derived from Parkinson’s disease patient-iPSCs with LRRK2-G2019S mutation Open
Despite extensive research, the contribution of the LRRK2 p.G2019S mutation to Parkinson’s disease (PD) remains unclear. Recent findings indicate oligodendrocytes (ODCs) and their progenitors are vulnerable in PD pathogenesis. Notably, oli…
View article: data for Frontiers in Endocrinology article (doi: 10.3389/fendo.2024.1258982)
data for Frontiers in Endocrinology article (doi: 10.3389/fendo.2024.1258982) Open
Data (shared sequence variants) for the publication "Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene. Frontiers in Endocrinology 2024. 15:1258982."
View article: To Study the Germination Effect on Finger Millet, Pearl Millet and Buckwheat: It’s Impact on Phytochemical Properties and Their Prebiotic Effect
To Study the Germination Effect on Finger Millet, Pearl Millet and Buckwheat: It’s Impact on Phytochemical Properties and Their Prebiotic Effect Open
Effect of germination temperature on the radicle length, phytochemical properties and prebiotic effect of finger millet, pearl millet and buckwheat were investigated.Germination of grain occurred at T1, T2, and T3 with different time range…
View article: ViSHWaS: Violence Study of Healthcare Workers and Systems—a global survey
ViSHWaS: Violence Study of Healthcare Workers and Systems—a global survey Open
Objective To provide insights into the nature, risk factors, impact and existing measures for reporting and preventing violence in the healthcare system. The under-reporting of violence against healthcare workers (HCWs) globally highlights…
View article: A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass
A new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass Open
There remains much that we do not understand about the earliest stages of human development. On a gross level, there is evidence for apoptosis, but the nature of the affected cell types is unknown. Perhaps most importantly, the inner cell …
View article: Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1
Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1 Open
Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 functio…
View article: Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson’s disease
Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson’s disease Open
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem contro…
View article: Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease
Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease Open
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem contro…
View article: Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease
Single-nucleus RNA-sequencing reveals oligodendrocytes and their progenitors as vulnerable cell types in prefrontal cortex and anterior cingulate of brains with Parkinson's disease Open
Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson's disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from post-mortem contro…
View article: SARS-CoV-2 infection activates endogenous retroviruses of the LTR69 subfamily
SARS-CoV-2 infection activates endogenous retroviruses of the LTR69 subfamily Open
Accumulating evidence suggests that endogenous retroviruses (ERVs) play an important role in the host response to infection and the development of disease. By combining RNA- and ChIP-sequencing analyses with RT-qPCR, we show that SARS-CoV-…
View article: Application of Traditional Vaccine Development Strategies to SARS-CoV-2
Application of Traditional Vaccine Development Strategies to SARS-CoV-2 Open
The development, production, and distribution of vaccines is imperative to saving lives, preventing illness, and reducing the economic and social burdens caused by the COVID-19 pandemic. Vaccines that use cutting-edge biotechnology have pl…
View article: The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism
The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism Open
The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an international collaboration producing fundamental resources for Parkinson disease (PD). FOUNDIN-PD generated a multi-layered molecular dataset in a cohort of induced…
View article: Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH
Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH Open
A role of CD4+ T cells during the progression from nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) has been suggested, but which polarization state of these cells characterizes this progression and the devel…
View article: ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control
ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control Open
The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a ta…