Explanipedia

Comparative analysis of laser thermotherapy and cryotherapy efficacy in the treatment of retinoblastoma of peripheral localization Open

D.P. Volodin, A.A. Yarovoy, Andrey Alexeev, V.А. Yarovaya · 2025

Purpose. To evaluate the efficacy of laser thermotherapy (TT) and cryotherapy (CT) in the treatment of retinoblastoma of peripheral localization in standardized groups using comparative analysis. Material and methods. Comparative analysis …

Combined stereotactic radiation therapy and immunotherapy for metastatic uveal melanoma Open

V.V. Nazarova, Kristina V. Orlova, Z.R. Magomedova, Д. С. Романов, Raman Maskalenka , et al. · 2025

Aim Uveal melanoma (UM) is a rare primary intraocular malignant tumor with an extremely poor prognosis. Our study evaluated the feasibility to improve metastatic UM treatment outcomes with a combined approach of immunotherapy and radiation…

Uveal melanoma in children and adolescents: clinical features and treatment approaches according to 30-years’ experience Open

А.А. Yarovoy, Andrei Alekseev, D.P. Volodin, А. D. Matyaeva, V.А. Yarovaya · 2025

Relevance. The number of uveal melanomas (UM) in the structure of melanomas of the visual organ and its adnexa is approximately 85 %. This malignant intraocular neoplasm affects mainly the adult population. UM is a rather rare phenomenon a…

Choroidal metastases: clinical and diagnostic features based on 10-years’ experience Open

A.A. Yarovoi, V.I. Miroshnikov, A. G. Galbatsova, V.А. Yarovaya, D.P. Volodin · 2025

Purpose. To present our personal experience of observation of patients with choroidal metastases. Material and methods. Medical data of 49 patients were analyzed with diagnosis of choroidal metastasis during the period from 2013 to 2023. T…

Intraocular surgery in children with pretreated retinoblastoma: long-term results Open

A.A. Yarovoy, D.P. Volodin, А.С. Алексеев, V.А. Yarovaya, И. Г. Осокин , et al. · 2025

Aim: to evaluate long-term clinical and functional results, as well as local and systemic safety of intraocular surgery (IOS) in children with pretreated retinoblastoma (RB). Materials and Methods: from 2012 to 2023, the IOS was performed …

Primary endoresection of choroidal melanoma: 10-year experience results Open

А.А. Yarovoy, I.M. Gorshkov, V.А. Yarovaya, V.I. Miroshnikov, D.P. Volodin · 2025

Aim: to present 10-year experience results in choroidal melanoma (CM) management by primary endoresection (ER). Materials and Methods: 35 patients (35 eyes) with CM aged from 30 to 75 years (mean — 58 years) were treated by the primary ER …

Treatment of Metastatic Uveal Melanoma. The Experience of a Leading Reference Center Open

V.V. Nazarova, Z.R. Magomedova, Kristina V. Orlova, E.A. Azarova, V. M. Unguryan , et al. · 2024

Uveal melanoma (UM) is the most common primary intraocular tumor. Despite successful treatment of the primary tumor, 50% of patients develop distant metastases. To date, there are no clear standards for choosing the first line of therapy f…

Local treatment efficacy in different stages of retinoblastoma Open

А.А. Yarovoy, D.P. Volodin, V.А. Yarovaya, А. М. Чочаева · 2024

Background . Nowadays local modalities play an important role in retinoblastoma (Rb) treatment. Despite a great number of publications in scientific literature about local treatment there are no scientific works about comparative analysis …

Results of anti-VEGF therapy in patients with uveal melanoma Open

V.А. Yarovaya, E.O. Malakshinova, V.A. Pismenskaya, Р. А. Логинов, A.A. Yarovoi · 2024

Relevance. Radiation retinopathy (RR) in the form of macular edema (ME) is a predictable complication of radiation therapy (RT) in uveal melanoma (UM). ME is the main reason for the decrease in visual acuity (VA) after RT. By reducing visu…

Uveal melanoma: the value of molecular genetic testing for early detection of metastatic disease. Clinical case Open

V.А. Yarovaya, Andrey Golanov, V.V. Nazarova, А. R. Zaretskii, I. А. Levashov , et al. · 2024

To date, the issue of not only timely diagnosis and treatment of patients with uveal melanoma (UM), but also the prediction of this pathology remains relevant. The technology of fine needle aspiration biopsy (FNAB) makes it possible to ass…

Prognostic fine needle aspiration biopsy of uveal melanoma: Molecular and genetic factors of metastasis risk Open

V.А. Yarovaya, I. А. Levashov, Andrew R. Zaretsky, L. V. Chudakova, V.V. Nazarova , et al. · 2023

Introduction. Molecular genetic testing is actively used for prognostication in patients with uveal melanoma (UM). Tissue for genetic analysis may be obtained either by surgical excision or through fine-needle aspiration biopsy (FNAB). Per…

Primary endoprosthetics of the orbit with a silicone implant in patients with retinoblastoma Open

A. V. Kotelnikova, V.А. Yarovaya, Т. Л. Ушакова, E. P. Sudakova, А. D. Matyaeva , et al. · 2023

Relevance . Currently there are various methods of organ-preserving treatment of retinoblastoma (RB), but nevertheless, eyeball enucleation remains one of the main methods of its treating. After removal of the eyeball, children face cosmet…

Intravitreal anti-vascular endothelial growth factor treatment in patients with radiation retinopathy following plaque radiotherapy for uveal melanoma Open

E. P. Sudakova, V.А. Yarovaya, E.O. Malakshinova · 2023

Relevance. Radiation retinopathy and maculopathy are the most common causes of visual impairment in patients with uveal melanoma treated with plaque radiotherapy. There are no standards of medical care for such patients, and various therap…

Combined Immunotherapy for Metastatic Uveal Melanoma. Single Centre Experience Open

V.V. Nazarova, Kristina V. Orlova, Igor Utyashev, A.A. Yarovoy, V.А. Yarovaya , et al. · 2023

Uveal melanoma (UM) is the most common intraocular tumor. Despite satisfactory results in the treatment of primary uveal melanoma, almost 50% of patients develop a metastatic lesion. Overall one-year survival in patients with metastatic uv…

Reply Open

Paul T. Finger, Ankit Singh Tomar, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

Cryotherapy of retinoblastoma: 13-year experience Open

А.А. Yarovoy, D.P. Volodin, V.А. Yarovaya, Т. Л. Ушакова, Е.S. Kotova , et al. · 2022

Introduction. Cryotherapy (CT) is one of the main methods of small retinoblastoma (Rb) treatment and remains the “gold standard” for the treatment of small tumors of pre-equatorial localization, however, the number of studies in the litera…

Stereotactic Gamma Knife® Radiosurgery of Intraocular Retinoblastoma: Six-Year Experience Open

А.А. Yarovoy, Andrey Golanov, V.А. Yarovaya, Valery Kostjuchenko, D.P. Volodin · 2022

Metastatic risk of prognostic fine-needle aspiration biopsy in u veal melanoma patients Open

I. А. Levashov, A.A. Yarovoi, V.А. Yarovaya, Е. С. Булгакова · 2022

Despite the widespread u se of fine-needle aspiration biopsy (FNAB) of uveal melanoma (UM) for prognostic purposes, there are still doubts about the safety of this procedure. No analysis of such data can be found in domestic literature, an…

Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda L. Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

Comprehensive analysis of chromosome 8 abnormalities and its prognostic value in patients with uveal melanoma Open

V.А. Yarovaya, А.А. Yarovoy, L. V. Chudakova, I. А. Levashov, A. R. Zaretskiy · 2022

Introduction. Uveal melanoma ability to metastasize depends on a few prognostic factors. The genetic ones are considered to be the most significant. The role of disorders of the short arm of chromosome 8 (8p), as well as a combination of c…

Transpupillary laser thermotherapy of retinoblastoma Open

А.А. Yarovoy, D.P. Volodin, V.А. Yarovaya, Т. Л. Ушакова, Е.S. Kotova , et al. · 2021

Introduction. Despite the fact that transpupillary thermotherapy (TTT) is one of the main local methods of small retinoblastoma (RB) destruction, only a few studies have been published on the use of this method, and they are devoted only t…

Results of cataract surgery in children with retinoblastoma Open

А.А. Yarovoy, V.А. Yarovaya, И. Г. Осокин, Е.S. Kotova, D.P. Volodin · 2021

Purpose. To present results of cataract surgery in children with retinoblastoma. Material and methods. Within the period from 2012 to 2020, cataract surgery was performed in 21 children (22 eyes) with retinoblastoma aged 28 to 155 months (…

Brachytherapy for retinoblastoma: a 13 year experience Open

А.А. Yarovoy, V.А. Yarovaya, Е.S. Kotova, Т. Л. Ушакова, Andrey Golanov , et al. · 2021

Brachytherapy (BT) is a method of radiation therapy with radioactive source contacting the tumor. It was proposed by P. Moore and H. Stallard in 1929. Despite those 50 years of experience with the use of BT in ophthalmic oncology, there ar…

Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2021

Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data w…

Gamma Knife stereotactic radiosurgery for intraocular retinoblastoma: a 5-year experience Open

А.А. Yarovoy, Andrey Golanov, Т. Л. Ушакова, V. V. Kostyuchenko, V.А. Yarovaya , et al. · 2021

External beam radiotherapy (EBR) remained for a long time the only method of treatment in children with recurrent and resistant retinoblastoma (RB). This method often leads to serious complications, including the occurrence of secondary ma…

Incidence of Retinoblastoma Has Increased: Results from 40 European Countries Open

Andrew W. Stacey, Richard Bowman, Allen Foster, Tero Kivelä, Francis L. Munier , et al. · 2021

The role of three-component selective intra-arterial chemotherapy in the failure of standard organ-preserving treatment in children with intraocular retinoblastoma Open

Т. Л. Ушакова, А. С. Волкова, О. В. Горовцова, А.А. Yarovoy, V.А. Yarovaya , et al. · 2021

Introduction . Retinoblastoma (RB) is a malignant tumor of the retina, the survival rate for the intraocular form reaches 99 %. According to the researchers, the risk factors for the occurrence of refractory or recurrent forms of RB are th…

Uveal melanoma dissemination within the scleral tract in fine needle aspiration biopsy Open

V.А. Yarovaya, А. В. Шацких, I. А. Levashov, А.А. Yarovoy · 2020

Introduction. Fine needle aspiration biopsy (FNAB) of uveal melanoma (UM) is an invasive procedure. Many authors consider UM FNAB to be safe procedure, however extraocular extension of the tumor through the scleral tracts may occur. Curren…

Global Retinoblastoma Treatment Outcomes Open

Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2020

This international, multicenter, registry-based analysis of retinoblastoma management revealed that lower national income levels were associated with significantly higher rates of metastasis-related mortality, local treatment failure, and …

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