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STUDY OF THE INFLUENCE OF PREBIOTICS ON THE CONTENTS OF ANTIBODIES TO VIRUSES AND MICROBES OF THE RESPIRATORY GROUP IN PALATINE TONSIL CELL CULTURE OF PATIENTS WITH CHRONIC TONSILLITIS IN EXPERIMENT IN VITRO Open

Oleg F. Melnikov, Dmytro Zabolotnyi, Мarina D. Timchenko, Inna V. Faraon, M B Sambur , et al. · 2024

Purpose: In recent decades, the activity and points of influence of probiotics, microelement compounds and vitamins, which play a significant role as cofactors in maintaining the immune system, both local and systemic, specific and innate,…

RECURRENT TONSILLITIS IN THE SETTING OF KLEBSIELLA PNEUMONIAE-ASSOCIATED INFECTION Open

Oleg F. Melnikov, Kotov Oleksandr V Kotov Oleksandr, V. E. Kotov · 2024

Among the gram-negative flora, Klebsiella pneumoniae is the leading causative agent of recurrent tonsillitis. The high level of pathogenicity and antibiotic resistance of Klebsiella pneumoniae infection is due to the following factors: hig…

PB0143 Induced B Cell Tolerance in Hemophilia A Mice is Destroyed by Infections Open

B. Jurado-Mestre, A. Abdelmageed, V. E. Kotov, T. Albert, Johannes Oldenburg , et al. · 2023

Background: Haemophilia A is an X-linked bleeding disorder characterized by a deficiency of factor VIII (FVIII).Patients may develop anti-FVIII antibodies, rendering FVIII therapy ineffective.Antibody production can be suppressed by target…

Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs Open

Janine Becker-Gotot, Mirjam Meissner, V. E. Kotov, B. Jurado-Mestre, Andréa Maione , et al. · 2022

A major complication of hemophilia A therapy is the development of alloantibodies (inhibitors) that neutralize intravenously administered coagulation factor VIII (FVIII). Immune tolerance induction therapy (ITI) by repetitive FVIII injecti…

Towards Generic Deobfuscation of Windows API Calls Open

V. E. Kotov, Michael Wojnowicz · 2018

A common way to get insight into a malicious program's functionality is to look at which API functions it calls. To complicate the reverse engineering of their programs, malware authors deploy API obfuscation techniques, hiding them from a…

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