Explanipedia

Penile cancer awareness and knowledge among adult patients in an ambulatory urology clinic Open

Nick Kamkari, Vadim Osadchiy, Erika L. Wood, Kristen Williams, Eduardo Piqueiras , et al. · 2025

Penile cancer (PeCa) is a rare urologic malignancy in the United States, and public awareness remains low. In this brief report, we design and execute a survey to evaluate knowledge and awareness of PeCa focusing on general PeCa knowledge,…

Epigenetic aging of semen is associated with inflammation Open

Junxi Feng, Liudmilla Rubbi, Reza Kianian, Jesse N. Mills, Vadim Osadchiy , et al. · 2024

Male infertility has been a primary cause of global infertility, affecting 8-12% of couples worldwide. Previous studies have shown that semen quality decreases with advanced aging with an increased presence of inflammatory cells. In this s…

Semen static oxidation–reduction potential is not helpful in evaluating male fertility Open

T Furtado, Vadim Osadchiy, Marcelo H. Furtado · 2024

Background Infertility affects a significant percentage of couples worldwide, with male infertility contributing substantially in a considerable number of cases. Research indicates that oxidative stress is a critical factor impacting male …

The Promise of Artificial Intelligence in Peyronie’s Disease Open

T Furtado, Vadim Osadchiy, Sriram V. Eleswarapu · 2024

Understanding Pediatric Experiences With Symptomatic Varicoceles: Mixed Methods Study of an Online Varicocele Community Open

Grace E Sollender, Tommy Jiang, Ilana Finkelshtein, Vadim Osadchiy, Michael Zheng , et al. · 2024

Background Varicoceles affect up to 30% of postpubertal adolescent males. Studying this population remains difficult due to this topic’s sensitive nature. Using the popularity of social media in this cohort and natural language processing …

Urine microbes and predictive metagenomic profiles associate with abnormalities in sperm parameters: implications for male subfertility Open

Vadim Osadchiy, André Belarmino, Reza Kianian, John T. Sigalos, Thiago P Furtado , et al. · 2024

Our findings underscore differences in the urinary microbiome and abnormalities in semen parameters, especially sperm motility. By incorporating predictive functional profiling, we also highlight possible mechanisms that may drive the obse…

Combination clomiphene citrate and anastrozole duotherapy improves semen parameters in a multi-institutional, retrospective cohort of infertile men Open

Vadim Osadchiy, Carlos Muñoz-López, Tommy Jiang, Bryan Naelitz, Neel Parekh , et al. · 2024

In men with impaired semen parameters, empiric medical therapies such as clomiphene citrate, a selective estrogen receptor modulator (SERM), and anastrozole, a selective aromatase inhibitor, are often employed. The effects of jointly admin…

Semen microbiota are dramatically altered in men with abnormal sperm parameters Open

Vadim Osadchiy, André Belarmino, Reza Kianian, John T. Sigalos, Jacob Ancira , et al. · 2024

There has recently been an explosion of studies implicating the human microbiome in playing a critical role in many disease and wellness states. The etiology of abnormal semen analysis (SA) parameters is not identified in 30% of cases; inv…

The Interplay of Varicoceles, Sperm Epigenetics, and Male Infertility: A Focused, Contemporary Review Open

Grace E. Sollender, André Belarmino, T Furtado, Vadim Osadchiy, Jesse N. Mills , et al. · 2024

Despite the wide recognition of varicocele as a contributor to infertility, its exact pathophysiologic mechanism is not fully understood. As the field of male infertility continues to see progress in new diagnostic and therapeutic technolo…

Epigenetic aging of seminal fluid is associated with inflammation Open

Junxi Feng, Liudmilla Rubbi, Reza Kianian, Jesse N. Mills, Vadim Osadchiy , et al. · 2023

Male infertility has been a primary cause of global infertility, affecting 8–12% of couples worldwide. Previous studies have shown that semen quality decreases with advanced aging with an increased presence of inflammatory cells. In this s…

Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut Open

Xiaobei Zhang, Hao Wang, Lisa A. Kilpatrick, Tien S. Dong, Gilbert C. Gee , et al. · 2023

Experiences of discrimination are associated with adverse health outcomes, including obesity. However, the mechanisms by which discrimination leads to obesity remain unclear. Utilizing multi-omics analyses of neuroimaging and fecal metabol…

Application of a natural language processing approach to understand adolescents’ perceptions of varicoceles (Preprint) Open

Grace E Sollender, Tommy Jiang, Ilana Finkelshtein, Vadim Osadchiy, Michael Zheng , et al. · 2023

BACKGROUND Varicoceles affect up to 30% of postpubertal adolescent males. Studying this population remains difficult due to this topic’s sensitive nature. Using the popularity of social media in this cohort and natural language processing…

Identifying Targets for Innovation in Amazon Reviews of Bedwetting Alarms: Thematic Analysis Open

Astha Sahoo, Savannah Starr, Vadim Osadchiy, Sophia Desai, Neha Iyer , et al. · 2023

Background Nocturnal enuresis (NE) is a frequent diagnosis in pediatric and adolescent populations with an estimated prevalence of around 15% at the age of 6 years. NE can have a substantial impact on multiple health domains. Bedwetting al…

Machine learning model to predict obesity using gut metabolite and brain microstructure data Open

Vadim Osadchiy, Roshan Bal, Emeran A. Mayer, Rama Kunapuli, Tien S. Dong , et al. · 2023

A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions may contribute to obesity pathogenesis. In this study, we use a machine learning approach to leverage the enormous amount of microstructu…

A multi-omic brain gut microbiome signature differs between IBS subjects with different bowel habits Open

Rachel P. Sarnoff, Ravi R. Bhatt, Vadim Osadchiy, Tien S. Dong, Jennifer S. Labus , et al. · 2022

How Discrimination Gets Under the Skin: Biological Determinants of Discrimination Associated With Dysregulation of the Brain-Gut Microbiome System and Psychological Symptoms Open

Tien S. Dong, Gilbert C. Gee, Hiram Beltrán‐Sánchez, May D. Wang, Vadim Osadchiy , et al. · 2022

Discrimination is attributed to changes in the BGM system more skewed toward inflammation, threat response, emotional arousal, and psychological symptoms. By integrating diverse lines of research, our results demonstrate evidence that may …

Identifying Targets for Innovation in Amazon Reviews of Bedwetting Alarms: Thematic Analysis (Preprint) Open

Astha Sahoo, Savannah Starr, Vadim Osadchiy, Sophia Desai, Neha Iyer , et al. · 2022

BACKGROUND Nocturnal enuresis (NE) is a frequent diagnosis in pediatric and adolescent populations with an estimated prevalence of around 15% at the age of 6 years. NE can have a substantial impact on multiple health domains. Bedwetting a…

Temporal Changes of Clomiphene on Testosterone Levels and Semen Parameters in Subfertile Men Open

Tommy Jiang, John T. Sigalos, Vadim Osadchiy, Alvaro Santamaria, Michael Zheng , et al. · 2022

Duration of treatment with clomiphene may impact testosterone and sperm concentration, and the historical 3 month milestone may be insufficient for clinical and research evaluation. Men taking CC may experience plateau in TT at 6 months an…

Initial gonadotropin levels and sperm parameters differentiate the response to clomiphene citrate in subfertile men Open

Tommy Jiang, Vadim Osadchiy, Alvaro Santamaria, Michael Zheng, Neilufar Modiri , et al. · 2022

Men with lower gonadotropin levels may expect greater degree of improvement in both hormone and semen parameters with use of CC. Men with azoospermia do not benefit based on semen analyses alone. Degree of non-azoospermia does not affect m…

3D-printed phantoms to quantify accuracy and variability of goniometric and volumetric assessment of Peyronie’s disease deformities Open

Dyvon T. Walker, Tommy Jiang, Alvaro Santamaria, Vadim Osadchiy, Doug Daniels , et al. · 2021

Characterization of Peyronie’s disease (PD) involves manual goniometry and penile length measurement. These techniques neglect volume loss or hourglass deformities. Inter-provider variability complicates accuracy. Using 3D-printed models, …

MP31-17 PRE-TREATMENT SEX HORMONE LEVELS AND SPERM CONCENTRATION INFLUENCE MAGNITUDE OF RESPONSE TO CLOMIPHENE IN SUBFERTILE MEN Open

Tommy Jiang, Alvaro Santamaria, Neilufar Modiri, Michael Zheng, Vadim Osadchiy , et al. · 2021

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-17 PRE-TREATMENT SEX HORMONE LEVELS AND SPERM CONCENTRATION INFLUENCE MAGNITUDE OF RESPONSE TO CLOMIPHENE IN SUBFERTILE MEN Tommy Jiang, Alvaro Santamaria, Neilufar…

MP31-16 GONADOTROPIN CONCENTRATION THRESHOLDS TO PREDICT IMPROVEMENTS IN TESTOSTERONE AND SEMEN PARAMETERS WITH CLOMIPHENE CITRATE Open

Tommy Jiang, Alvaro Santamaria, Neilufar Modiri, Michael Zheng, Vadim Osadchiy , et al. · 2021

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-16 GONADOTROPIN CONCENTRATION THRESHOLDS TO PREDICT IMPROVEMENTS IN TESTOSTERONE AND SEMEN PARAMETERS WITH CLOMIPHENE CITRATE Tommy Jiang, Alvaro Santamaria, Neiluf…

Re: Patrick Lewicki, Spyridon P. Basourakos, Bashir Al Hussein Al Awamlh, et al. Estimating the Impact of COVID-19 on Urology: Data from a Large Nationwide Cohort. Eur Urol Open Sci 2021;25:52–6 Open

Tommy Jiang, Sriram V. Eleswarapu, Vadim Osadchiy · 2021

Early life adversity predicts brain-gut alterations associated with increased stress and mood Open

Elena J.L. Coley, Emeran A. Mayer, Vadim Osadchiy, Zixi Chen, Vishvak Subramanyam , et al. · 2021

Alterations in the brain-gut system have been implicated in various disease states, but little is known about how early-life adversity (ELA) impacts development and adult health as mediated by brain-gut interactions. We hypothesize that EL…

Brain–Gut–Microbiome Interactions and Intermittent Fasting in Obesity Open

Juliette Frank, Arpana Gupta, Vadim Osadchiy, Emeran A. Mayer · 2021

The obesity epidemic and its metabolic consequences are a major public health problem both in the USA and globally. While the underlying causes are multifactorial, dysregulations within the brain–gut–microbiome (BGM) system play a central …

Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals Open

Soumya Ravichandran, Ravi R. Bhatt, Bilal Pandit, Vadim Osadchiy, Anita Alaverdyan , et al. · 2021

Impact of the COVID-19 Pandemic on Patient Preferences and Decision Making for Symptomatic Urolithiasis Open

Tommy Jiang, Vadim Osadchiy, James M. Weinberger, Michael Zheng, Michael H. Owen , et al. · 2021

Background: Pandemic restrictions have changed how patients approach symptomatic kidney stones. We used a mixed-methods digital ethnographic approach to evaluate social media discussions about patient concerns and preferences…

Digital ethnographic analysis of prostate cancer discussions on social media Open

Sriram V. Eleswarapu, Tommy Jiang, Jesse N. Mills, Vadim Osadchiy · 2020

Men struggling with prostate cancer report significant decision-related distress surrounding cancer surveillance and treatment.1, 2 Typically, prostate cancer shared decision making (SDM) involves three main parties: the patient, patient's…

Analysis of brain networks and fecal metabolites reveals brain–gut alterations in premenopausal females with irritable bowel syndrome Open

Vadim Osadchiy, Emeran A. Mayer, Kan Gao, Jennifer S. Labus, Bruce D. Naliboff , et al. · 2020

Alterations in brain–gut–microbiome (BGM) interactions have been implicated in the pathogenesis of irritable bowel syndrome (IBS). Here, we apply a systems biology approach, leveraging neuroimaging and fecal metabolite data, to characteriz…

Low Testosterone on Social Media: Application of Natural Language Processing to Understand Patients’ Perceptions of Hypogonadism and Its Treatment Open

Vadim Osadchiy, Tommy Jiang, Jesse N. Mills, Sriram V. Eleswarapu · 2020

Background Despite the results of the Testosterone Trials, physicians remain uncomfortable treating men with hypogonadism. Discouraged, men increasingly turn to social media to discuss medical concerns. Objective The goal of the research w…

Vadim Osadchiy YOU? Author Swipe