Vaibhav B. Patel
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View article: Drp1 promotes vascular smooth muscle cell death via adverse mitochondrial dynamics
Drp1 promotes vascular smooth muscle cell death via adverse mitochondrial dynamics Open
Vascular smooth muscle cell (vSMC) death has been linked to the pathogenesis of various vascular diseases. Although mitochondrial dynamics play an important role in cellular homeostasis, excessive mitochondrial fission in response to patho…
View article: Pharmacological inhibition of mitochondrial fission mitigates experimental thoracic aortic aneurysm
Pharmacological inhibition of mitochondrial fission mitigates experimental thoracic aortic aneurysm Open
Thoracic aortic aneurysm (TAA) is increasingly recognized as a vascular degenerative disease and is typically diagnosed incidentally due to its asymptomatic nature. TAA is clinically associated with the dilation of the aorta and excessive …
View article: Macrophages in vascular disease: Roles of mitochondria and metabolic mechanisms
Macrophages in vascular disease: Roles of mitochondria and metabolic mechanisms Open
Macrophages are a dynamic cell type of the immune system implicated in the pathophysiology of vascular diseases and are a major contributor to pathological inflammation. Excessive macrophage accumulation, activation, and polarization is ob…
View article: Current concepts in the epigenetic regulation of cardiac fibrosis
Current concepts in the epigenetic regulation of cardiac fibrosis Open
Cardiac fibrosis is a significant driver of congestive heart failure, a syndrome that continues to affect a growing patient population globally. Cardiac fibrosis results from a constellation of complex processes at the transcription, recep…
View article: Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis
Exploring the role of pericardial miRNAs and exosomes in modulating cardiac fibrosis Open
The potential of the pericardial space as a therapeutic delivery tool for cardiac fibrosis and heart failure (HF) treatment has yet to be elucidated. Recently, miRNAs and exosomes have been discovered to be present in human pericardial flu…
View article: Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells Open
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. The escalating global occurrence of obesity and diabetes mellitus (DM) has led to a significant upsurge in individuals afflicted with CVDs. As the …
View article: Exome-wide comparative analyses revealed differentiating genomic regions for performance traits in Indian native buffaloes
Exome-wide comparative analyses revealed differentiating genomic regions for performance traits in Indian native buffaloes Open
In India, 20 breeds of buffalo have been identified and registered, yet limited studies have been conducted to explore the performance potential of these breeds, especially in the Indian native breeds. This study is a maiden attempt to del…
View article: Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm
Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) represents a debilitating vascular disease characterized by aortic dilatation and wall rupture if it remains untreated. We aimed to determine the effects of Ang 1-7 in a murine model of AAA and to investigat…
View article: Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm
Attenuation of Smooth Muscle Cell Phenotypic Switching by Angiotensin 1-7 Protects against Thoracic Aortic Aneurysm Open
Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, leading to reduced biomechanical support with risk of aortic dissection and rupture. Activation of the renin-angiotensin system, and resultan…
View article: Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues
Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues Open
Aims Structural analogues of bisphenol A (BPA), including BPS and BPF, are emerging environmental toxicants as their presence in the environment is rising since new regulatory restrictions were placed on BPA-containing infant products. The…
View article: Medial Collagen Type and Quantity Influence Mechanical Properties of Aneurysm Wall in Bicuspid Aortic Valve Patients
Medial Collagen Type and Quantity Influence Mechanical Properties of Aneurysm Wall in Bicuspid Aortic Valve Patients Open
Collagen has an essential role in aortic biomechanics, and collagen remodeling has been associated with the development and progression of aortic aneurysm. However, the exact mechanisms behind collagen remodeling and the biomechanical impl…
View article: Adventitial Fibroblasts in Aortic Aneurysm: Unraveling Pathogenic Contributions to Vascular Disease
Adventitial Fibroblasts in Aortic Aneurysm: Unraveling Pathogenic Contributions to Vascular Disease Open
Aortic aneurysm (AA) is a degenerative vascular disease that involves aortic dilatation, and, if untreated, it can lead to rupture. Despite its significant impact on the healthcare system, its multifactorial nature and elusive pathophysiol…
View article: Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy
Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy Open
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or hypertension, leading to heart failure and increased risk for death in diabetic patients. To investigate the molecular mechanisms involved in DbCM, we perfor…
View article: Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger Open
Cardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recover…
View article: IL-1 Signal Inhibition In Alcoholic Hepatitis (ISAIAH): a study protocol for a multicentre, randomised, placebo-controlled trial to explore the potential benefits of canakinumab in the treatment of alcoholic hepatitis
IL-1 Signal Inhibition In Alcoholic Hepatitis (ISAIAH): a study protocol for a multicentre, randomised, placebo-controlled trial to explore the potential benefits of canakinumab in the treatment of alcoholic hepatitis Open
Background Alcohol consumption causes a spectrum of liver abnormalities and leads to over 3 million deaths per year. Alcoholic hepatitis (AH) is a florid presentation of alcoholic liver disease characterized by liver failure in the context…
View article: Commentary: Cell therapy goes subcellular
Commentary: Cell therapy goes subcellular Open
View article: Role of Exosomal Intercellular Communications in Diabetic Vascular Complications in Experimental Animals
Role of Exosomal Intercellular Communications in Diabetic Vascular Complications in Experimental Animals Open
Background: Cardiovascular complications are the main cause of death in diabetic patients. Intercellular communications may link diabetes to the cardiovascular complications. Exosomes are now emerging as a key mediator of intercellular com…
View article: Spectrophotometric method development and validation for simultaneous estimation of Anagliptin and Metformin HCl BY Q - Absorption ratio method in synthetic mixture
Spectrophotometric method development and validation for simultaneous estimation of Anagliptin and Metformin HCl BY Q - Absorption ratio method in synthetic mixture Open
View article: Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload
Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload Open
Humans have a lower risk of death from myocardial infarction (MI) living at low elevations (5000 m, and intermittent hypobaric hypoxia post-MI can reduce MI size in rodents, and it is believed that hypoxia is the key stimulus. To explore m…
View article: PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction
PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction Open
Background Cancer therapies inhibiting PI 3Kα (phosphoinositide 3‐kinase‐α)–dependent growth factor signaling, including trastuzumab inhibition of HER 2 (Human Epidermal Growth Factor Receptor 2), can cause adverse effects on the heart. Di…
View article: PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease Open
View article: Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway
Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway Open
View article: Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis.
Comparison of in-hospital outcomes between octogenarians and nonagenarians undergoing transcatheter aortic valve replacement: a propensity matched analysis. Open
Although in-hospital mortality is slightly higher in nonagenarians, it is acceptable. This difference in mortality is at least partly explained by higher complications in nonagenarians. Efforts should be made to decrease the complications …
View article: TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease Open
Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloprotein…
View article: Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy
Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy Open
Iron-overload cardiomyopathy is prevalent on a worldwide basis and is a major comorbidity in patients with genetic hemochromatosis and secondary iron overload. Therapies are limited in part due to lack of a valid preclinical model, which r…
View article: Temporopolar bridging veins during anteromedial temporal strip placement: a case report on complication avoidance†
Temporopolar bridging veins during anteromedial temporal strip placement: a case report on complication avoidance† Open
Although much frequently less encountered than paramedian subdural strips, anterior medial temporal strip subdural electrodes may indeed injure large bridging veins. As subdural strips are passed where bony exposure is minimal, potential d…
View article: MNGI-11. TREATMENT OF MENINGIOMA WITH TH-302 IN A PDX MOUSE MODEL AND CELL LINE
MNGI-11. TREATMENT OF MENINGIOMA WITH TH-302 IN A PDX MOUSE MODEL AND CELL LINE Open
INTRODUCTION: Meningioma account for 36% of intracranial tumors and 4.7-7.2% demonstrate aggressive clinical behavior. Current treatments are limited to surgery and radiation. We investigated hypoxia activated prodrugTH302 in patient-deriv…
View article: Transcatheter or surgical aortic valve replacement in patients with advanced kidney disease: A propensity score–matched analysis
Transcatheter or surgical aortic valve replacement in patients with advanced kidney disease: A propensity score–matched analysis Open
Background Transcatheter aortic valve replacement (TAVR) is an alternative for surgically inoperable patients with severe aortic stenosis. Advanced kidney disease may significantly affect outcomes in patients treated with TAVR and surgical…
View article: Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin β1 Interaction
Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63–Integrin β1 Interaction Open
Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens. Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and diastolic performance. TIMP1 (tissue inhibitor of metall…
View article: Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress
Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress Open
Background Sex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure. However, whether s…