Vinood B. Patel
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View article: Evaluation of Antioxidant and Anti-Inflammatory Effects of a Nanoformulation Derived from Annurca Apple Callus Extract in an In Vitro Model of Iron Overload-Induced Inflammation
Evaluation of Antioxidant and Anti-Inflammatory Effects of a Nanoformulation Derived from Annurca Apple Callus Extract in an In Vitro Model of Iron Overload-Induced Inflammation Open
Ferroptosis, a regulated form of cell death driven by iron accumulation and lipid peroxidation, contributes to oxidative stress-related skin damage. This study evaluates the antioxidant and anti-inflammatory effects of a nanoformulation de…
View article: The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The Hepatoprotective Properties of Gentiopicroside, Sweroside, and Swertiamarin Against Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 30–38% of the world’s adult population have MASLD, making it the most preva…
View article: Curcumin Nanocarriers in the Protection Against Iron- and Alcohol-Induced Oxidative Stress in a Cellular Model of Liver Disease
Curcumin Nanocarriers in the Protection Against Iron- and Alcohol-Induced Oxidative Stress in a Cellular Model of Liver Disease Open
During chronic alcohol misuse, hepatic iron overload occurs, leading to exacerbated oxidative stress and liver injury. The aim was to study formulations encapsulated with the antioxidant curcumin to assess their ability protect against oxi…
View article: Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations
Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations Open
View article: Metronidazole-induced neurotoxicity: is iron a contributing factor?
Metronidazole-induced neurotoxicity: is iron a contributing factor? Open
Background Metronidazole-induced neurotoxicity is a rising challenge in the management of susceptible infections. The mechanisms involved in metronidazole-induced neurotoxicity are not fully unraveled. This study was aimed at determining t…
View article: Co-administration of curcumin forms with supplemental iron: a study of effects on iron absorption and intestinal cellular health
Co-administration of curcumin forms with supplemental iron: a study of effects on iron absorption and intestinal cellular health Open
Iron supplementation often causes gastrointestinal distress. Co-administration with formulated curcumin may help protect gastrointestinal health and enhance iron uptake by intestinal cells.
View article: A Study of Improvement in Quality of Life in Patients with Vernal Keratoconjunctivitis
A Study of Improvement in Quality of Life in Patients with Vernal Keratoconjunctivitis Open
Purpose: This study aimed to assess the effect of treatment of vernal keratoconjunctivitis (VKC) on the quality of life (QoL) in individuals across different age groups, including children, adolescents, and adults. This was achieved by uti…
View article: Current Screening Tests/Biomarkers for Alzheimer's Disease: Implications for Clinicians.
Current Screening Tests/Biomarkers for Alzheimer's Disease: Implications for Clinicians. Open
View article: Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line
Antioxidant and Antidiabetic Properties of a Thinned-Nectarine-Based Nanoformulation in a Pancreatic β-Cell Line Open
Pancreatic β-cells play a crucial role in maintaining glucose homeostasis, although they are susceptible to oxidative damage, which can ultimately impair their functionality. Thinned nectarines (TNs) have gained increasing interest due to …
View article: Repeated Treatment with Antimalarial Agents Causes In Vitro Liver Toxicity
Repeated Treatment with Antimalarial Agents Causes In Vitro Liver Toxicity Open
Aim In Africa’s malaria-endemic regions, artesunate/amodiaquine (A/A) and artemether/lumefantrine (A/L) are the antimalarial medications that are most frequently prescribed. Antimalarial medications could be overused if they are self-presc…
View article: Baseline and recurrent exposure to the standard dose of artemisinin-based combination therapies (ACTs) induces oxidative stress and liver damage in mice (BALB/c)
Baseline and recurrent exposure to the standard dose of artemisinin-based combination therapies (ACTs) induces oxidative stress and liver damage in mice (BALB/c) Open
Background In malaria-endemic countries, repeated intake of artemisinin-based combination therapies (ACTs) is rampant and driven by drug resistance, improper usage, and easy accessibility. Stress effects and potential liver toxicity due to…
View article: Effect of Short-Term Oral Vitamin A on Ocular Tear Film in Dry Eye
Effect of Short-Term Oral Vitamin A on Ocular Tear Film in Dry Eye Open
Purpose: Dry eye disease (DED) is a multifactorial disease of tears and ocular surface. The tear film is composed of three layers – lipid, aqueous, and mucin. Loss of mucin and goblet cell atrophy due to Vitamin A deficiency contributes to…
View article: Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments Open
The robotic liver resection (RLR) has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system, however, controversies still exist. Based on the foundati…
View article: The Effects of Frequent Therapeutic Administration of Artesunate-amodiaquine and Artemether-lumefantrine on Haematological Markers in BALB/c Mice
The Effects of Frequent Therapeutic Administration of Artesunate-amodiaquine and Artemether-lumefantrine on Haematological Markers in BALB/c Mice Open
Artemisinin Combination Therapy (ACT) is readily available in malaria-endemic nations, leading to repeated drug usage by undiagnosed persons. Repeated use of ACT therapy by non-infected individuals may affect blood cells. This study explor…
View article: Handbook of Anger, Aggression, and Violence
Handbook of Anger, Aggression, and Violence Open
From a criminological point of view, homicide-suicide represents a “double death” and takes on a meaning that transcends the specificity of the two events individually understood, which, although diametrically opposed on the phenomenal lev…
View article: Eating Disorders
Eating Disorders Open
This handbook unravels links between eating disorders and health-related outcomes and provides practical, useful information for diagnosis and treatment.
View article: Biomarkers in Diabetes
Biomarkers in Diabetes Open
View article: Time-Dependent Alterations in Liver Oxidative Stress due to Ethanol and Acetaldehyde
Time-Dependent Alterations in Liver Oxidative Stress due to Ethanol and Acetaldehyde Open
Binge drinking is a major public health issue and ethanol-related liver insult may play a major role in the pathology of alcoholic liver disease. However, the degree of oxidative stress, cell death and contribution of acetaldehyde to liver…
View article: Handbook of Substance Misuse and Addictions
Handbook of Substance Misuse and Addictions Open
This handbook offers a holistic understanding of the relationship between substance misuse and public health, biology, behavior, psychology, and sociology.
View article: Alcoholic liver disease: Current insights into cellular mechanisms
Alcoholic liver disease: Current insights into cellular mechanisms Open
Alcoholic liver disease (ALD) due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality. Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular …
View article: Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells
Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells Open
Exposure to high levels of glucose and iron are co-related to reactive oxygen species (ROS) generation and dysregulation of insulin synthesis and secretion, although the precise mechanisms are not well clarified. The focus of this study wa…
View article: Acute Alcohol Tissue Damage: Protective Properties of Betaine
Acute Alcohol Tissue Damage: Protective Properties of Betaine Open
Teenage binge drinking is a major health issue; however, there is a paucity of data on liver injury. Herein, we investigated how acute ethanol affects juvenile hepatic cells through changes in oxidative stress, apoptosis, and liver functio…
View article: Research and recommended resources on Zika virus, pathology, and control
Research and recommended resources on Zika virus, pathology, and control Open
View article: High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells
High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells Open
High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD de…
View article: Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication
Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communication Open
View article: Measurement of 4-Hydroxynonenal (4-HNE) Protein Adducts by ELISA
Measurement of 4-Hydroxynonenal (4-HNE) Protein Adducts by ELISA Open
Enzyme linked immunosorbent assay (ELISA) is a widely used technique for the measurement of antigens and antibodies alike. We describe here procedures, indirect ELISA and sandwich ELISA for the detection of 4-hydroxynonenal protein adducts…
View article: Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease
Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease Open
Background/aims Intestinal permeability with systemic distribution of bacterial products are central in the immunopathogenesis of alcoholic liver disease (ALD), yet links with intestinal immunity remain elusive. Mucosa-associated invariant…
View article: Erratum to: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
Erratum to: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication Open
Background: In liver hepatocytes, the HFE gene regulates cellular and systemic iron homeostasis by modulating cellular iron-uptake and producing the iron-hormone hepcidin in response to systemic iron elevation. However, the mechanism of ir…
View article: HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication
HFE mRNA expression is responsive to intracellular and extracellular iron loading: short communication Open
The original article has been changed to reflect the correct co-author name: Sebastien Farnaud. The original article was corrected.
View article: Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells
Iron Enhances Hepatic Fibrogenesis and Activates Transforming Growth Factor-β Signaling in Murine Hepatic Stellate Cells Open