Vaidya Govindarajan
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View article: Synergistic Treatment with Antiretrovirals and Laser Interstitial Thermal ThErapy (STARLITE) for unresectable glioblastoma: A phase 1 study protocol
Synergistic Treatment with Antiretrovirals and Laser Interstitial Thermal ThErapy (STARLITE) for unresectable glioblastoma: A phase 1 study protocol Open
Glioblastoma (GBM) is the most common form of primary adult brain tumor with a five-year survival of <7%. Standard of care (SoC) involves maximal safe surgical resection with chemoradiation; nevertheless, most patients experience disease p…
View article: Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models
Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models Open
Viral mimicry refers to the activation of innate antiviral immune responses due to the induction of endogenous retroelements (REs). Viral mimicry augments antitumor immune responses and sensitizes solid tumors to immunotherapy. Here, we fo…
View article: Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma
Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma Open
Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune responses and sensitize …
View article: Antiretroviral Drug Repositioning for Glioblastoma
Antiretroviral Drug Repositioning for Glioblastoma Open
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding no…
View article: The Role of Emboli Detection Studies in Acute Inpatient Vertebral Artery Dissection
The Role of Emboli Detection Studies in Acute Inpatient Vertebral Artery Dissection Open
View article: Effects of Obesity on Cervical Disc Arthroplasty Complications
Effects of Obesity on Cervical Disc Arthroplasty Complications Open
Objective: High body mass index is a well-established modifiable comorbidity that is known to increase postoperative complications in all types of surgery, including spine surgery. Obesity is increasing in prevalence amongst the general po…
View article: Metagenome analyses identify human endogenous retrovirus–K113 (HML-2) subtype in glioblastoma. Reply.
Metagenome analyses identify human endogenous retrovirus–K113 (HML-2) subtype in glioblastoma. Reply. Open
View article: Laser Interstitial Thermal Therapy Induces Robust Local Immune Response for Newly Diagnosed Glioblastoma With Long-term Survival and Disease Control
Laser Interstitial Thermal Therapy Induces Robust Local Immune Response for Newly Diagnosed Glioblastoma With Long-term Survival and Disease Control Open
Laser interstitial thermal therapy (LITT) is a minimally invasive neurosurgical technique used to ablate intra-axial brain tumors. The impact of LITT on the tumor microenvironment is scarcely reported. Nonablative LITT-induced hyperthermia…
View article: Impact of COVID-19 pandemic on treatment and outcomes of cerebral arteriovenous malformations
Impact of COVID-19 pandemic on treatment and outcomes of cerebral arteriovenous malformations Open
Background There has been a recent decrease in interventional management of cerebral arteriovenous malformations (AVMs). The objective of our study was to evaluate the changing patterns in management of AVMs in the first year of the COVID-…
View article: Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma
Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma Open
Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8% of the human genome. Although normally silenced, the most recently integrated provirus HERV-K (HML-2) can be reactivated in certain cancers. Here, w…
View article: Outcomes in patients with large vessel occlusion strokes undergoing mechanical thrombectomy with concurrent COVID-19: a nationwide retrospective analysis
Outcomes in patients with large vessel occlusion strokes undergoing mechanical thrombectomy with concurrent COVID-19: a nationwide retrospective analysis Open
Background Preliminary studies show that patients with large vessel occlusion (LVO) acute ischemic strokes have worse outcomes with concurrent COVID-19 infection. We investigated the outcomes for patients with LVO strokes undergoing mechan…
View article: Chiari I malformation management in patients with heritable connective tissue disorders
Chiari I malformation management in patients with heritable connective tissue disorders Open
View article: Transradial Access Failures During Neuroangiography for Patients With Moyamoya
Transradial Access Failures During Neuroangiography for Patients With Moyamoya Open
BACKGROUND: Despite studies continuing to demonstrate the utility of transradial access (TRA) in neuroangiography, minimal data exist regarding predictors of TRA failure. Furthermore, although many patients with moyamoya disease/syndrome w…
View article: Predicting Academic Career Placement via Development of Novel Intra-residency Metrics
Predicting Academic Career Placement via Development of Novel Intra-residency Metrics Open
View article: Transdural Approach for Resection of Craniovertebral Junction Cysts: Case Series
Transdural Approach for Resection of Craniovertebral Junction Cysts: Case Series Open
BACKGROUND: Craniovertebral junction (CVJ) cysts, including retro-odontoid pseudotumors, are challenging pathologies to treat and manage effectively. Surgical intervention is indicated when these lesions result in progressive myelopathy, i…
View article: EPCO-33. DIFFERENTIAL EXPRESSION OF AN ENDOGENOUS RETROVIRAL ELEMENT [HERV-K(HML-6)] IS ASSOCIATED WITH REDUCED SURVIVAL IN GLIOBLASTOMA PATIENTS
EPCO-33. DIFFERENTIAL EXPRESSION OF AN ENDOGENOUS RETROVIRAL ELEMENT [HERV-K(HML-6)] IS ASSOCIATED WITH REDUCED SURVIVAL IN GLIOBLASTOMA PATIENTS Open
INTRODUCTION Comprising approximately 8% of our genome, Human Endogenous RetroViruses (HERVs) represent a class of germline retroviral infections that are regulated through epigenetic modifications. In cancer cells, which often have epigen…
View article: EXTH-34. ANTI-RETROVIRAL REPURPOSING FOR TREATMENT OF GLIOBLASTOMA
EXTH-34. ANTI-RETROVIRAL REPURPOSING FOR TREATMENT OF GLIOBLASTOMA Open
Glioblastoma (GBM) is a WHO grade IV glioma whose heterogeneous nature and stem-like features contribute to resistance to conventional chemotherapeutics. Previously, antiretrovirals have been proposed as anti-neoplastic agents, but their c…
View article: STEM-07. DEFINING THE ROLE OF HUMAN ENDOGENOUS RETROVIRUS-K (HML-2) IN THE GLIOBLASTOMA STEM-CELL NICHE
STEM-07. DEFINING THE ROLE OF HUMAN ENDOGENOUS RETROVIRUS-K (HML-2) IN THE GLIOBLASTOMA STEM-CELL NICHE Open
Human Endogenous Retrovirus (HERV) are ancestral viral relics that comprise nearly 8% of the human genome. Although silenced in normal tissues, the most recently integrated provirus HERV-K (HML-2) can be pathologically reactivated in certa…
View article: The Role of HERV-K in Cancer Stemness
The Role of HERV-K in Cancer Stemness Open
Human endogenous retrovirus-K (HERV-K) is the most recently integrated retrovirus in the human genome, with implications for multiple disorders, including cancer. Although typically transcriptionally silenced in normal adult cells, dysregu…
View article: National reduction in cerebral arteriovenous malformation treatment correlated with increased rupture incidence
National reduction in cerebral arteriovenous malformation treatment correlated with increased rupture incidence Open
Background Recently, there has been a shift in management of unruptured cerebral arteriovenous malformations (AVMs) following studies suggesting that medical management alone was superior to interventional therapy. Objective To evaluate th…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients
Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients Open
View article: Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma
Systematic Review of Epigenetic Therapies for Treatment of IDH-mutant Glioma Open
View article: A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines
A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines Open
Background Poor prognosis of glioblastoma patients and the extensive heterogeneity of glioblastoma at both the molecular and cellular level necessitates developing novel individualized treatment modalities via genomics-driven approaches. M…
View article: The role of an anterior approach in the treatment of ankylosing spondylitis–associated cervical fractures: a systematic review and meta-analysis
The role of an anterior approach in the treatment of ankylosing spondylitis–associated cervical fractures: a systematic review and meta-analysis Open
OBJECTIVE Cervical fractures in patients with ankylosing spondylitis can have devastating neurological consequences. Currently, several surgical approaches are commonly used to treat these fractures: anterior, posterior, and anterior-poste…
View article: Osteoporosis treatment in patients undergoing spinal fusion: a systematic review and meta-analysis
Osteoporosis treatment in patients undergoing spinal fusion: a systematic review and meta-analysis Open
OBJECTIVE Bisphosphonates and teriparatide are the most common therapies used in the treatment of osteoporosis. Their impact on fusion rates in osteoporotic patients following spinal fusion has yet to be concretely defined, with previous s…
View article: Vertebral multiple myeloma with pathological fracture: the most common etiology for emergency spine surgery in patients with no cancer diagnosis on admission
Vertebral multiple myeloma with pathological fracture: the most common etiology for emergency spine surgery in patients with no cancer diagnosis on admission Open
OBJECTIVE Vertebral compression fractures are common in multiple myeloma (MM). Modern treatment paradigms place emphasis on treatment with radiation, with surgery reserved for cases involving frank instability or severe neural compression.…
View article: The Focused Neurosurgical Examination During Telehealth Visits: Guidelines During the COVID-19 Pandemic and Beyond
The Focused Neurosurgical Examination During Telehealth Visits: Guidelines During the COVID-19 Pandemic and Beyond Open
View article: Medical Adjuvants in the Treatment of Surgically Refractory Arteriovenous Malformations of the Head and Face: Case Report and Review of Literature
Medical Adjuvants in the Treatment of Surgically Refractory Arteriovenous Malformations of the Head and Face: Case Report and Review of Literature Open
Background: Arteriovenous malformations (AVMs) of the brain and face present unique challenges for clinicians. Cerebral AVMs may induce hemorrhage or form aneurysms, while facial AVMs can cause significant disfigurement and p…
View article: Early Changes to Neurosurgery Resident Training During the COVID-19 Pandemic at a Large U.S. Academic Medical Center
Early Changes to Neurosurgery Resident Training During the COVID-19 Pandemic at a Large U.S. Academic Medical Center Open