Valentin Blanchard
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View article: Post-translational modifications of apolipoproteins as promising biomarkers for diabetes-related cardiovascular diseases: A comprehensive review
Post-translational modifications of apolipoproteins as promising biomarkers for diabetes-related cardiovascular diseases: A comprehensive review Open
Lipoproteins are biochemical complexes of apolipoproteins and lipids that primarily mediate the transport of lipids through the circulation, from sites of absorption or synthesis to those of use, storage, or excretion. In type 2 diabetes (…
View article: Lysosomal acid lipase deficiency: A rare inherited dyslipidemia but potential ubiquitous factor in the development of atherosclerosis and fatty liver disease
Lysosomal acid lipase deficiency: A rare inherited dyslipidemia but potential ubiquitous factor in the development of atherosclerosis and fatty liver disease Open
Lysosomal acid lipase (LAL), encoded by the gene LIPA , is the sole neutral lipid hydrolase in lysosomes, responsible for cleavage of cholesteryl esters and triglycerides into their component parts. Inherited forms of complete (Wolman Dise…
View article: Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location
Smooth Muscle Cell—Macrophage Interactions Leading to Foam Cell Formation in Atherosclerosis: Location, Location, Location Open
Cholesterol-overloaded cells or “foam cells” in the artery wall are the biochemical hallmark of atherosclerosis, and are responsible for much of the growth, inflammation and susceptibility to rupture of atherosclerotic lesions. While it ha…
View article: Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia
Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia Open
Supplementation with ω3FA reduces postprandial TRL-apo(a) response to a fat meal in FH patients; this novel metabolic effect of ω3FA may have implications on decreasing the risk of ASCVD in patients with FH, especially in those with elevat…
View article: Circulating HDL and Non-HDL Associated Apolipoproteins and Breast Cancer Severity
Circulating HDL and Non-HDL Associated Apolipoproteins and Breast Cancer Severity Open
Plasma lipids are carried within lipoproteins with various apolipoprotein content. This study evaluates the interest of measuring the apolipoproteins of circulating lipoproteins in breast cancer. Patients with early-stage breast cancer (n …
View article: Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes
Plasma apolipoprotein concentrations and incident diabetes in subjects with prediabetes Open
View article: Macrophages in Atherosclerosis, First or Second Row Players?
Macrophages in Atherosclerosis, First or Second Row Players? Open
Macrophages represent a cell type that has been widely described in the context of atherosclerosis since the earliest studies in the 17th century. Their role has long been considered to be preponderant in the onset and aggravation of ather…
View article: Effects of proprotein convertase subtilisin kexin type 9 modulation in human pancreatic beta cells function
Effects of proprotein convertase subtilisin kexin type 9 modulation in human pancreatic beta cells function Open
View article: Plasma concentrations of lipoproteins and risk of lower-limb peripheral artery disease in people with type 2 diabetes: the SURDIAGENE study
Plasma concentrations of lipoproteins and risk of lower-limb peripheral artery disease in people with type 2 diabetes: the SURDIAGENE study Open
View article: Biochemical, Epidemiological and Clinical Investigation of Lipoprotein (a) Metabolism
Biochemical, Epidemiological and Clinical Investigation of Lipoprotein (a) Metabolism Open
View article: Approches biochimique, épidémiologique et clinique du métabolisme intégré de la Lipoprotéine (a)
Approches biochimique, épidémiologique et clinique du métabolisme intégré de la Lipoprotéine (a) Open
One in five individuals in the population displays elevated circulating levels of lipoprotein (a) [Lp(a)], a highly atherogenic lipoprotein resembling LDL. Pathophysiological, epidemiological and genetic studies demonstrate that circulatin…
View article: A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins
A high-throughput mass spectrometry-based assay for large-scale profiling of circulating human apolipoproteins Open
View article: Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab
Lipoprotein(a) Cellular Uptake Ex Vivo and Hepatic Capture In Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab Open
Lipoprotein(a) (Lp[a]) is the most common genetically inherited risk factor for cardiovascular disease. Many aspects of Lp(a) metabolism remain unknown. We assessed the uptake of fluorescent Lp(a) in primary human lymphocytes as well as Lp…
View article: VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly
VLDL (Very-Low-Density Lipoprotein)-Apo E (Apolipoprotein E) May Influence Lp(a) (Lipoprotein [a]) Synthesis or Assembly Open
Objective: To clarify the association between PCSK9 (proprotein convertase subtilisin/kexin type 9) and Lp(a) (lipoprotein [a]), we studied Lp(a) kinetics in patients with loss-of-function and gain-of-function PCSK9 mutations and in patien…
View article: Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes
Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes Open
View article: Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia
Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia Open
niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
View article: Recurrent coronary syndromes in a patient with isolated very-high lipoprotein (a) and the prothrombin genetic variant rs1799963 (G20210A): a case report
Recurrent coronary syndromes in a patient with isolated very-high lipoprotein (a) and the prothrombin genetic variant rs1799963 (G20210A): a case report Open
The rare association between extremely elevated circulating Lp(a) levels and prothrombotic genetic variants of coagulation factors appears to be a deadly combination that can only be adequately treated by antiplatelet therapy and lipoprote…
View article: PCSK9: from biology to clinical applications
PCSK9: from biology to clinical applications Open
View article: Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study
Kinetics of plasma apolipoprotein E isoforms by LC-MS/MS: a pilot study Open
Human apoE exhibits three major isoforms (apoE2, apoE3, and apoE4) corresponding to polymorphism in the APOE gene. Total plasma apoE concentrations are closely related to these isoforms, but the underlying mechanisms are unknown. We…
View article: Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor)
Homozygous Familial Hypercholesterolemia Patients With Identical Mutations Variably Express the LDLR (Low-Density Lipoprotein Receptor) Open
Objective— Evolocumab, a PCSK9 (proprotein convertase subtilisin kexin type 9)–neutralizing antibody, lowers low-density lipoprotein cholesterol (LDL-C) in homozygous familial hypercholesterolemic (HoFH) patients with reduced LDLR (low-den…
View article: Stable Isotope Kinetic Study of ApoM (Apolipoprotein M)
Stable Isotope Kinetic Study of ApoM (Apolipoprotein M) Open
Objective— ApoM (apolipoprotein M) binds primarily to high-density lipoprotein before to be exchanged with apoB (apolipoprotein B)–containing lipoproteins. Low-density lipoprotein (LDL) receptor–mediated clearance of apoB-containing partic…