Valentin Evsyukov
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View article: Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity
Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity Open
Parkinson’s disease (PD) is histopathologically defined by the presence of Lewy bodies, which are intracellular proteinaceous inclusions that contain mainly aggregated alpha-synuclein (aSyn). It is believed that oligomeric intermediates be…
View article: Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity
Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity Open
Parkinson’s disease (PD) is histopathologically defined by the presence of Lewy bodies, which are intracellular proteinaceous inclusions that contain mainly aggregated alpha-synuclein (aSyn). It is believed that oligomeric intermediates be…
View article: Common Variants Near <scp>ZIC1</scp> and <scp>ZIC4</scp> in Autopsy‐Confirmed Multiple System Atrophy
Common Variants Near <span>ZIC1</span> and <span>ZIC4</span> in Autopsy‐Confirmed Multiple System Atrophy Open
Background Multiple System Atrophy is a rare neurodegenerative disease with alpha‐synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautono…
View article: Binding Stability of Antibody—α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies
Binding Stability of Antibody—α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies Open
Spreading of alpha-synuclein (αSyn) may play an important role in Parkinson’s disease and related synucleinopathies. Passive immunization with anti-αSyn antibodies is a promising method to slow down the spreading process and thereby the pr…
View article: Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near <i>ZIC1</i> and <i>ZIC4</i>
Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near <i>ZIC1</i> and <i>ZIC4</i> Open
Multiple System Atrophy is a rare neurodegenerative disease with alpha-synuclein aggregation in glial cytoplasmic inclusions and either predominant olivopontocerebellar atrophy or striatonigral degeneration, leading to dysautonomia, parkin…
View article: Non-invasive and high-throughput interrogation of exon-specific isoform expression
Non-invasive and high-throughput interrogation of exon-specific isoform expression Open
Expression of exon-specific isoforms from alternatively spliced mRNA is a fundamental mechanism that substantially expands the proteome of a cell. However, conventional methods to assess alternative splicing are either consumptive and work…
View article: Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes
Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes Open
Growing evidence suggests that epigenetic mechanisms like microRNA-mediated transcriptional regulation contribute to the pathogenesis of parkinsonism. In order to study the influence of microRNAs (miRNAs), we analyzed the miRNome 2 days pr…
View article: Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models
Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models Open
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting nucleolar dysfunction as a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/f…