2025-09-02
Modular Deep-Learning Pipelines for Dental Caries Data Streams: A Twin-Cohort Proof-of-Concept
2025-09-02 • Ştefan Lucian Burlea, Călin Gheorghe Buzea, Florin Nedeff, Diana Mirilă, Valentin Nedeff, Maricel Agop, Dragoș Ioan Rusu, Laura Elisabeta Checheriță
Background: Dental caries arise from a multifactorial interplay between microbial dysbiosis, host immune responses, and enamel degradation visible on radiographs. Deep learning excels in image-based caries detection; however, integrative analyses that combine radiographic, microbiome, and transcriptomic data remain rare because public cohorts are seldom aligned. Objective: To determine whether three independent deep-learning pipelines—radiographic segmentation, microbiome regression, and transcriptome regression—c…