Philippe Rousseau
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View article: Perceptions and use of self-management support strategies to improve the management of spine pain patients in a French-Canadian chiropractic teaching program: a mixed method study
Perceptions and use of self-management support strategies to improve the management of spine pain patients in a French-Canadian chiropractic teaching program: a mixed method study Open
Background Clinical guidelines for managing non-specific spine pain recommend providing patient education and self-management support strategies (SMSS) as first-line treatment. However, SMSS implementation in daily chiropractic care remain…
View article: <i>R</i>-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity
<i>R</i>-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity Open
Mutation, deletion, or silencing of genes encoding cellular metabolism factors occurs frequently in human malignancies. Neomorphic mutations in isocitrate dehydrogenases 1 and 2 (IDH1/2) promoting the production of R-2-hydroxyglutarate (R-…
View article: Interplay between the Xer recombination system and the dissemination of antibioresistance in <i>Acinetobacter baumannii</i>
Interplay between the Xer recombination system and the dissemination of antibioresistance in <i>Acinetobacter baumannii</i> Open
Antibiotic-resistant infections are a pressing clinical challenge. Plasmids are known to accelerate the emergence of resistance by facilitating horizontal gene transfer of antibiotic resistance genes between bacteria. We explore this quest…
View article: Clinical Document Improvement in Surgical Residency Training
Clinical Document Improvement in Surgical Residency Training Open
Background Accurate clinical documentation is essential for patient care, interdisciplinary communication, quality metrics reporting, and hospital reimbursement. Many hospitals face significant revenue losses due to inadequate or incomplet…
View article: The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae
The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae Open
Bacterial genomes contain a plethora of secondary replicons of divergent size. Circular replicons must carry a system for resolving dimeric forms, resulting from recombination between sister copies. These systems use site-specific recombin…
View article: Redefining the bacteriophage mv4 site‐specific recombination system and the sequence specificity of its <scp><i>attB</i></scp> and <scp>core‐<i>attP</i></scp> sites
Redefining the bacteriophage mv4 site‐specific recombination system and the sequence specificity of its <span><i>attB</i></span> and <span>core‐<i>attP</i></span> sites Open
Through their involvement in the integration and excision of a large number of mobile genetic elements, such as phages and integrative and conjugative elements (ICEs), site‐specific recombination systems based on heterobivalent tyrosine re…
View article: Interplay between the Xer recombination system and the dissemination of antibioresistance in<i>Acinetobacter baumannii</i>
Interplay between the Xer recombination system and the dissemination of antibioresistance in<i>Acinetobacter baumannii</i> Open
Antibiotic-resistant infections pose a pressing challenge in clinical settings. Plasmids are widely recognized for hastening the emergence of resistance by facilitating horizontal gene transfer of antibiotic resistance genes among bacteria…
View article: The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae
The pathway to resolve dimeric forms distinguishes plasmids from megaplasmids in Enterobacteriaceae Open
Bacterial genomes contain a plethora of secondary replicons of divergent size. Circular replicons must carry a system for resolving dimeric forms, resulting from recombination between sister copies. These systems use site-specific recombin…
View article: Combined free flap of muscle-sparing <i>latissimus dorsi</i> and serratus anterior in the repair of child’s traumatic foot injury: a case report
Combined free flap of muscle-sparing <i>latissimus dorsi</i> and serratus anterior in the repair of child’s traumatic foot injury: a case report Open
Multi-tissue injuries to the foot are common in the pediatric population. Microsurgical repairs are part of the therapeutic arsenal in pediatric reconstructive surgery. We report the case of a 4-year-old boy involved in a lawnmower acciden…
View article: Characterisation and reprogramming of bacteriophage mv4 integrase recombination specificity
Characterisation and reprogramming of bacteriophage mv4 integrase recombination specificity Open
Bacteriophage mv4 is a temperate bacterial virus able to integrate its genome at the 3’ end of the tRNA SER of Lactobacillus delbrueckii subsp. bulgaricus chromosome through site-specific recombination. Previous investigations revealed tha…
View article: DNA Segregation in Enterobacteria
DNA Segregation in Enterobacteria Open
DNA segregation ensures that cell offspring receive at least one copy of each DNA molecule, or replicon, after their replication. This important cellular process includes different phases leading to the physical separation of the replicons…
View article: A subclass of the IS<i>1202</i>family of bacterial insertion sequences targets XerCD recombination sites
A subclass of the IS<i>1202</i>family of bacterial insertion sequences targets XerCD recombination sites Open
IS 1202 , originally isolated from Streptococcus pneumonia in the mid-1990s had been previously tagged as an emerging IS family in ISfinder. While searching for plasmid-associated Xer recombinase recombination sites ( xrs ) in Acinetobacte…
View article: Outcomes and Reliability of Perforator Flaps in the Reconstruction of Hidradenitis Suppurativa Defects: A Systemic Review and Meta-Analysis
Outcomes and Reliability of Perforator Flaps in the Reconstruction of Hidradenitis Suppurativa Defects: A Systemic Review and Meta-Analysis Open
Introduction: Hidradenitis suppurativa (HS) is a common and debilitating disease, in which the only effective treatment involves a wide excision of the affected skin. Secondary wound healing and skin grafting are two well-known options for…
View article: Seeded free-electron laser driven by a compact laser plasma accelerator
Seeded free-electron laser driven by a compact laser plasma accelerator Open
Free-electron lasers generate high-brilliance coherent radiation at wavelengths spanning from the infrared to the X-ray domains. The recent development of short-wavelength seeded free-electron lasers now allows for unprecedented levels of …
View article: Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence
Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence Open
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular se…
View article: Devices Used to Measure Force-Time Characteristics of Spinal Manipulations and Mobilizations: A Mixed-Methods Scoping Review on Metrologic Properties and Factors Influencing Use
Devices Used to Measure Force-Time Characteristics of Spinal Manipulations and Mobilizations: A Mixed-Methods Scoping Review on Metrologic Properties and Factors Influencing Use Open
Background: Spinal manipulations (SMT) and mobilizations (MOB) are interventions commonly performed by many health care providers to manage musculoskeletal conditions. The clinical effects of these interventions are believed to be, at leas…
View article: ALGINATE versus NPWT in the Preparation of Surgical Excisions for an STSG: ATEC Trial
ALGINATE versus NPWT in the Preparation of Surgical Excisions for an STSG: ATEC Trial Open
Background: A calcium alginate dressing (ALGINATE) and negative pressure wound therapy (NPWT) are frequently used to treat wounds which heal by secondary intention. This trial compared the healing efficacy and safety of these 2 treatments.…
View article: An Improved Xer-cise Technology for the Generation of Multiple Unmarked Mutants in Mycobacteria
An Improved Xer-cise Technology for the Generation of Multiple Unmarked Mutants in Mycobacteria Open
Xer-cise is a technique using antibiotic resistance cassettes flanked by dif sites allowing spontaneous and accurate excision from bacterial chromosomes with a high frequency through the action of the cellular recombinase XerCD. Here, we r…
View article: Dynamical control of denaturation bubble nucleation in supercoiled DNA minicircles
Dynamical control of denaturation bubble nucleation in supercoiled DNA minicircles Open
We examine the behavior of supercoiled DNA minicircles containing between 200 and 400 base-pairs, also named microDNA, in which supercoiling favors thermally assisted DNA denaturation bubbles of nanometer size and controls their lifetime. …
View article: An improved Xer-cise technology for the generation of multiple unmarked mutants in Mycobacteria
An improved Xer-cise technology for the generation of multiple unmarked mutants in Mycobacteria Open
Summary Xer-cise is a technique using antibiotic resistance cassettes flanked by dif sites allowing spontaneous and accurate excision from bacterial chromosomes with a high frequency through the action of the cellular recombinase XerCD. He…
View article: Post-replicative pairing of sister <i>ter</i> regions in <i>Escherichia coli</i> involves multiple activities of MatP
Post-replicative pairing of sister <i>ter</i> regions in <i>Escherichia coli</i> involves multiple activities of MatP Open
The ter region of the bacterial chromosome, where replication terminates, is the last to be segregated before cell division in Escherichia coli . Delayed segregation is controlled by the MatP protein, which binds to specific sites ( matS )…
View article: Control of DNA denaturation bubble nucleation to advance nano-biosensing
Control of DNA denaturation bubble nucleation to advance nano-biosensing Open
In the demanding biosensing environment, improving selection efficiency strategies has become an issue of great significance. DNA minicircles containing between 200 and 400 base-pairs, also named microDNA, are representative of the superco…
View article: Publisher Correction: Control of laser plasma accelerated electrons for light sources
Publisher Correction: Control of laser plasma accelerated electrons for light sources Open
The original version of this Article contained an error in the last sentence of the first paragraph of the Introduction and incorrectly read ‘A proper electron beam control is one of the main challenges towards the Graal of developing a co…
View article: How does temperature impact the conformation of single DNA molecules below melting temperature?
How does temperature impact the conformation of single DNA molecules below melting temperature? Open
The double stranded DNA molecule undergoes drastic structural changes during biological processes such as transcription during which it opens locally under the action of RNA polymerases. Local spontaneous denaturation could contribute to t…