Valentin М. Tabakmakher
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View article: Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels
Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels Open
Here, we introduce the third release of Kalium database ( http://kaliumdb.org/ ), a manually curated comprehensive depository that accumulates data on polypeptide ligands of potassium channels. The major goal of this amplitudinous update i…
View article: Structural Optimization of an α-Hairpinin Blocking Potassium Channels K<sub>V</sub>1.3
Structural Optimization of an α-Hairpinin Blocking Potassium Channels K<sub>V</sub>1.3 Open
Obtaining compounds with specificity for certain isoforms of ion channels is a significant problem of curent physiology and pharmacology. In a series of papers, we have shown that the α-hairpinin fold can serve as a template for the ration…
View article: Artificial pore blocker acts specifically on voltage-gated potassium channel isoform KV1.6
Artificial pore blocker acts specifically on voltage-gated potassium channel isoform KV1.6 Open
View article: Differences in Medium-Induced Conformational Plasticity Presumably Underlie Different Cytotoxic Activity of Ricin and Viscumin
Differences in Medium-Induced Conformational Plasticity Presumably Underlie Different Cytotoxic Activity of Ricin and Viscumin Open
Structurally similar catalytic subunits A of ricin (RTA) and viscumin (MLA) exhibit cytotoxic activity through ribosome inactivation. Ricin is more cytotoxic than viscumin, although the molecular mechanisms behind this difference are still…
View article: Potassium channel blocker crafted by α-hairpinin scaffold engineering
Potassium channel blocker crafted by α-hairpinin scaffold engineering Open
View article: Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model
Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model Open
Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and receptors, demonstrating analgesic, anti-inflammatory, anti-histamine and many other biological activities. A…
View article: Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3
Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3 Open
Voltage-gated potassium channels (KVs) perform vital physiological functions and are targets in different disorders ranging from ataxia and arrhythmia to autoimmune diseases. An important issue is the search for and production o…
View article: Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide
Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide Open
Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subun…
View article: MD snapshots: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering
MD snapshots: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering Open
Snapshots of molecular dynamics (MD) simulations of 25 complexes of Kv1.3 channel with a series of Tk-hefu peptide analogues (25 different peptides). Each system include solvated lipid bilayer, the channel and the peptide at 0 (before MD) …
View article: MD snapshots: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering
MD snapshots: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering Open
Snapshots of molecular dynamics (MD) simulations of 25 complexes of Kv1.3 channel with a series of Tk-hefu peptide analogues (25 different peptides). Each system include solvated lipid bilayer, the channel and the peptide at 0 (before MD) …
View article: Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering
Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering Open
Analysis of intermolecular contacts between the channel and the peptides for all systems in dynamics.H-bonds, salt bridges, stacking/π-π interactions, and cation-π interactions observed in 110 ns MD of complexes KV1.3 with Tk-hefu, Tk-hefu…
View article: MD snapshots and Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering
MD snapshots and Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering Open
Snapshots of molecular dynamics (MD) simulations of 25 complexes of Kv1.3 channel with a series of Tk-hefu peptide analogues (25 different peptides). Each system include solvated lipid bilayer, the channel and the peptide at 0 (before MD) …
View article: MD snapshots and Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering
MD snapshots and Supplementary Tables: Potassium channel blocker crafted by ɑ-hairpinin scaffold engineering Open
Snapshots of molecular dynamics (MD) simulations of 25 complexes of Kv1.3 channel with a series of Tk-hefu peptide analogues (25 different peptides). Each system include solvated lipid bilayer, the channel and the peptide at 0 (before MD) …
View article: Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker
Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker Open
Tk-hefu is an artificial peptide designed based on the α-hairpinin scaffold, which selectively blocks voltage-gated potassium channels Kv1.3. Here we present its spatial structure resolved by NMR spectroscopy and analyze its int…
View article: Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels
Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channels Open
View article: Kalium database
Kalium database Open
Complete copy of the Kalium database in MySQL format, six .sql files: stoxapp_activity.sql stoxapp_organism.sql stoxapp_organismclass.sql stoxapp_targetchannel.sql stoxapp_toxin.sql stoxapp_toxinfamily.sql Complete copy of the Kalium datab…
View article: CARD domain of rat RIP2 kinase: Refolding, solution structure, pH-dependent behavior and protein-protein interactions
CARD domain of rat RIP2 kinase: Refolding, solution structure, pH-dependent behavior and protein-protein interactions Open
RIP2, one of the RIP kinases, interacts with p75 neurotrophin receptor, regulating the neuron survival, and with NOD1 and NOD2 proteins, causing the innate immune response against gram-negative and gram-positive bacteria via its caspase re…
View article: Kalium database
Kalium database Open
Complete copy of Kalium 2.0 database in the CSV format, six .csv files: Activity.csv Organism.csv OrganismClass.csv TargetCannel.csv Toxin.csv ToxinFamily.csv export_all_tc.csv contains data in the format of concatenated Ligand cards prese…
View article: Kalium database
Kalium database Open
Kalium database (SQL) dump.
View article: High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method
High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method Open
View article: New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa
New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa Open
Sea anemones are a rich source of Kunitz-type polypeptides that possess not only protease inhibitor activity, but also Kv channels toxicity, analgesic, antihistamine, and anti-inflammatory activities. Two Kunitz-type inhibitors belonging t…