Valentina Mele
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View article: Mesoporous vs wrinkle silica nanoparticles: architecture driven loading of luminescence Ruthenium complexes
Mesoporous vs wrinkle silica nanoparticles: architecture driven loading of luminescence Ruthenium complexes Open
Silica nanoparticles (SNP) are widely recognized as versatile carriers for drug delivery and theranostics due to their exceptional properties, including tuneable pore structures, high surface area, biocompatibility, and chemical stability.…
View article: Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps
Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder whose complex immunopathogenesis has yet to be fully elucidated. Endotype-2 CRSwNP is the most common form of disease where eosinophils are the main driver…
View article: Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids
Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids Open
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
View article: Direct toll-like receptor triggering in colorectal cancer-associated stromal cells elicits immunostimulatory properties leading to enhanced immune cell recruitment
Direct toll-like receptor triggering in colorectal cancer-associated stromal cells elicits immunostimulatory properties leading to enhanced immune cell recruitment Open
View article: A Dihydroisoquinoline Platform Inspired from Natural Alkaloids as Ligand for Highly Cytotoxic Ruthenium-Based Photosensitizers: New Perspectives for Melanoma and Breast Cancer Treatment
A Dihydroisoquinoline Platform Inspired from Natural Alkaloids as Ligand for Highly Cytotoxic Ruthenium-Based Photosensitizers: New Perspectives for Melanoma and Breast Cancer Treatment Open
View article: Supplementary Figure 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Co-culture with PBNs does not impact on growth of CRC cell lines. (A) PBNs from healthy donors (HD) were co-cultured with 6 different CRC cell lines at a CRC: PBN ratio 1: 20, as described in “materials and methodsâ€�. After 72h, tumour …
View article: Legend from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Legend from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Supplementary legend figures
View article: Supplementary Figure 3 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 3 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
CD8+/PBN cross-talk is contact dependent. (A) Cumulative flow-cytometry histograms documenting CD69 expression in CD8+ T cells activated by using different concentrations of surface bound anti-CD3 (TR66, 0.5 and 2μg/ml) and soluble anti C…
View article: Supplementary Table 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Table 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Clinical-phatological characteristics of the CRC patient cohort and their association with levels of CD8+ and CD66b+ cell infiltrate.
View article: Supplementary Table 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Table 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Clinical-phatological characteristics of the CRC patient cohort and their association with levels of CD66b+ cell infiltrate.
View article: Data from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Data from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Purpose: Tumor infiltration by different T lymphocyte subsets is known to be associated with favorable prognosis in colorectal cancer. Still debated is the role of innate immune system. We investigated clinical relevance, phenotypes…
View article: Supplementary Table 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Table 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Clinical-phatological characteristics of the CRC patient cohort and their association with levels of CD8+ and CD66b+ cell infiltrate.
View article: Supplementary Figure 3 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 3 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
CD8+/PBN cross-talk is contact dependent. (A) Cumulative flow-cytometry histograms documenting CD69 expression in CD8+ T cells activated by using different concentrations of surface bound anti-CD3 (TR66, 0.5 and 2μg/ml) and soluble anti C…
View article: Data from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Data from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Purpose: Tumor infiltration by different T lymphocyte subsets is known to be associated with favorable prognosis in colorectal cancer. Still debated is the role of innate immune system. We investigated clinical relevance, phenotypes…
View article: Legend from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Legend from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Supplementary legend figures
View article: Supplementary Figure 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 2 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Co-culture with PBNs does not impact on growth of CRC cell lines. (A) PBNs from healthy donors (HD) were co-cultured with 6 different CRC cell lines at a CRC: PBN ratio 1: 20, as described in “materials and methodsâ€�. After 72h, tumour …
View article: Supplementary Figure 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Comparative phenotypic analysis of peripheral blood neutrophils from healthy donors and patients with CRC.
View article: Supplementary Figure 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Figure 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Comparative phenotypic analysis of peripheral blood neutrophils from healthy donors and patients with CRC.
View article: Supplementary Table 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer
Supplementary Table 1 from The Interplay Between Neutrophils and CD8<sup>+</sup> T Cells Improves Survival in Human Colorectal Cancer Open
Clinical-phatological characteristics of the CRC patient cohort and their association with levels of CD66b+ cell infiltrate.
View article: Data from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers
Data from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers Open
The genome-wide accumulation of DNA replication errors known as microsatellite instability (MSI) is the hallmark lesion of DNA mismatch repair (MMR)–deficient cancers. Although testing for MSI is widely used to guide clinical management, t…
View article: Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers
Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers Open
PDF file - 300K, Supplementary Figure 1: Immunohistochemical profiling of DNA mismatch repair proteins in the extra-osseous Ewing Sarcoma. Supplementary Figure 2: Fluorescence in situ hybridization (FISH) analysis of the MHS6-related extra…
View article: Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers
Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers Open
PDF file - 300K, Supplementary Figure 1: Immunohistochemical profiling of DNA mismatch repair proteins in the extra-osseous Ewing Sarcoma. Supplementary Figure 2: Fluorescence in situ hybridization (FISH) analysis of the MHS6-related extra…
View article: Data from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers
Data from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of <i>EWSR1</i> Are a Hallmark of Mismatch Repair–Deficient Cancers Open
The genome-wide accumulation of DNA replication errors known as microsatellite instability (MSI) is the hallmark lesion of DNA mismatch repair (MMR)–deficient cancers. Although testing for MSI is widely used to guide clinical management, t…
View article: Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells
Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells Open
Stromal infiltration is associated with poor prognosis in human colon cancers. However, the high heterogeneity of human tumor-associated stromal cells (TASCs) hampers a clear identification of specific markers of prognostic relevance. To a…
View article: Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis
Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis Open
Prognosis of gastric and esophageal cancer is poor and treatment improvements are needed. Programmed cell death 1 receptor (PD-1) interaction with its ligand PD-L1 in tumor micro-environment promotes immune tolerance and blocking monoclona…
View article: Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells
Liver biopsy derived induced pluripotent stem cells provide unlimited supply for the generation of hepatocyte-like cells Open
PLCs and Li-iPSCs obtained from small pieces of human needle liver biopsies constitute a novel unlimited source for the production of HLCs. Despite the preservation of a liver specific gene expression footprint in Li-iPSCs, the generation …
View article: Abstract 2821: Gut commensal bacteria modulate functions of tumor-associated neutrophils in human colorectal cancer
Abstract 2821: Gut commensal bacteria modulate functions of tumor-associated neutrophils in human colorectal cancer Open
Tumor infiltration by immune cells critically impacts on clinical outcome of human colorectal cancer (CRC). While high densities of CD8+ T cells and T-helper type 1 cells are associated with prolonged patient survival, the role of tumor-as…
View article: Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor‐Based 3D Culture System
Maintenance of Primary Human Colorectal Cancer Microenvironment Using a Perfusion Bioreactor‐Based 3D Culture System Open
Colorectal cancer (CRC) is a leading cause of cancer‐related death. Conventional chemotherapeutic regimens have limited success rates, and a major challenge for the development of novel therapies is the lack of adequate in vitro models. No…
View article: A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects <i>in vitro</i> and <i>in vivo</i>
A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects <i>in vitro</i> and <i>in vivo</i> Open
CD40 triggering may result in antitumor effects of potentially high clinical relevance. To gain insights important for patient selection and to identify adequate targeting techniques, we investigated CD40 expression in human cancer tissues…
View article: <i>Hemidesmus indicus</i> induces immunogenic death in human colorectal cancer cells
<i>Hemidesmus indicus</i> induces immunogenic death in human colorectal cancer cells Open
The ability of anticancer treatments to promote the activation of tumor-reactive adaptive immune responses is emerging as a critical requirement underlying their clinical effectiveness. We investigated the ability of Hemidesmus indicus<…