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View article: Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates
Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates Open
The endoplasmic reticulum (ER)'s continuous morphology is tightly controlled by ER-shaping proteins, whose genetic or expression defects drive a spectrum of neurodegenerative disorders from Hereditary Spastic Paraplegia to Alzheimer's dise…
View article: Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons Open
Disrupted cholesterol metabolism is increasingly recognised as a contributing factor in neurodegeneration; however, the specific effects of key brain-derived cholesterol metabolites, 24S-hydroxycholesterol (24S-HC) and 27-hydroxycholestero…
View article: Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport
Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport Open
Cell functions rely on intracellular transport systems distributing bioactive molecules with high spatiotemporal accuracy. The endoplasmic reticulum (ER) tubular network constitutes a system for delivering luminal solutes, including Ca
View article: Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport
Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport Open
Cell and tissue functions rely on an elaborate intracellular transport system responsible for distributing bioactive molecules with high spatiotemporal accuracy. The tubular network of the Endoplasmic Reticulum (ER) constitutes a system fo…