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View article: miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy
miR-451 Is a Driver of Lipotoxic Injury in Patients with Diabetic Cardiomyopathy Open
MicroRNA 451 (miR-451) is emerging as a pivotal mediator of cardiac damage in experimental models of diabetic cardiomyopathy. Whether miR-451 plays a detrimental role in the human diabetic myocardium is unknown. The present study investiga…
View article: Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease
Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease Open
View article: Epigenetic Network in Immunometabolic Disease
Epigenetic Network in Immunometabolic Disease Open
Although a large amount of data consistently shows that genes affect immunometabolic characteristics and outcomes, epigenetic mechanisms are also heavily implicated. Epigenetic changes, including DNA methylation, histone modification, and …
View article: Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature
Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature Open
Systemic arterial hypertension (AH) is a multifaceted disease characterized by accelerated vascular aging and high cardiometabolic morbidity and mortality. Despite extensive work in the field, the pathogenesis of AH is still incompletely u…
View article: Early rule-out and rule-in of myocardial infarction using sensitive cardiac Troponin I
Early rule-out and rule-in of myocardial infarction using sensitive cardiac Troponin I Open
When used in conjunction with other clinical information including the ECG, a simple algorithm incorporating s-cTnI values at presentation and after 1h (or 2h) will allow safe rule-out and accurate rule-in of AMI in the majority of patient…