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View article: Empowering Health Through Digital Lifelong Prevention: An Umbrella Review of Apps and Wearables for Nutritional Management
Empowering Health Through Digital Lifelong Prevention: An Umbrella Review of Apps and Wearables for Nutritional Management Open
Background/Objectives: The increasing use of electronic devices is reshaping lifestyle by offering new avenues for health behavior change. These tools provide to monitor health, fitness, and nutrition, promoting healthier lifestyles to pre…
View article: Citrus IntegroPectin: A Family of Bioconjugates With Large Therapeutic Potential
Citrus IntegroPectin: A Family of Bioconjugates With Large Therapeutic Potential Open
Citrus IntegroPectin is a family of bioconjugates sourced from different citrus fruits first isolated in 2019 via hydrodynamic cavitation of industrial citrus processing biowaste conducted in water only. Having a low methoxyl homogalacturo…
View article: Digital tools’ effectiveness on physical activity practice in healthy children and adolescents: an umbrella review within the DigitAl Lifelong pREvention (DARE) project (Preprint)
Digital tools’ effectiveness on physical activity practice in healthy children and adolescents: an umbrella review within the DigitAl Lifelong pREvention (DARE) project (Preprint) Open
BACKGROUND Children and adolescents do not meet the current guidelines for physical activity (PA). Interventions aimed at increasing their PA have been worldwide implemented through the use of different digital tools, but a clearer view o…
View article: Citrus IntegroPectin: a multifunctional bioactive phytocomplex with large therapeutic potential
Citrus IntegroPectin: a multifunctional bioactive phytocomplex with large therapeutic potential Open
Pectin is a bioactive polysaccharide widely investigated for its therapeutic properties as well as in tissue engineering and regenerative medicine for its gelling behavior, wound healing ability and high biocompatibility. First isolated in…
View article: Citrus IntegroPectin: a computational insight
Citrus IntegroPectin: a computational insight Open
Imparted with uniquely high and broad-scope bioactivity including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial and anticancer properties, the IntegroPectin bioconjugate obtained from citrus processing wa…
View article: Forecasting migraine attacks by managing daily lifestyle: a systematic review as a basis to develop predictive algorithms
Forecasting migraine attacks by managing daily lifestyle: a systematic review as a basis to develop predictive algorithms Open
Recent studies attempting to develop forecasting models for new migraine attack onsets, overviewing triggers and protectors, are encouraging but necessitate further improvements to produce forecasting models with high predictive accuracy. …
View article: Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model
Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet Rat Model Open
Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT’s antioxidant properties and its positive effects …
View article: Citrus IntegroPectin: a multifunctional bioactive phytocomplex with large therapeutic potential
Citrus IntegroPectin: a multifunctional bioactive phytocomplex with large therapeutic potential Open
Pectin is a bioactive polysaccharide widely investigated for its therapeutic properties as well as in tissue engineering and regenerative medicine for its gelling behavior, wound healing ability and high biocompatibility. First isolated in…
View article: Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats
Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats Open
The cross-talk between plant-derived nanovesicles (PDNVs) and mammalian cells has been explored by several investigations, underlining the capability of these natural nanovesicles to regulate several molecular pathways. Additionally, PDNVs…
View article: CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease Open
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin in neuronal cells. Overexpression of CNPY2 enhanc…
View article: Citrus IntegroPectin: a computational insight
Citrus IntegroPectin: a computational insight Open
Imparted with uniquely high and broad-scope bioactivity including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial and anticancer properties, the IntegroPectin phytocomplex obtained from citrus processing wa…
View article: Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line
Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line Open
In this study, we investigated the beneficial effects of grapefruit IntegroPectin, derived from industrial waste grapefruit peels via hydrodynamic cavitation, on microglia cells exposed to oxidative stress conditions. Grapefruit IntegroPec…
View article: Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model
Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model Open
"Golden" tomato (GT) plays a protective role in metabolic dysfunction induced by High-Fat Diet (HFD). Our aim is to characterize the phytonutrient composition of the juice and explore the influence of GT, orally administered for one month,…
View article: Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line
Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line Open
Background and aim Despite the intense research, most therapeutic strategies failed in preventing or treating neurodegenerative diseases, characterized by a combination of chronic neurodegeneration, oxidative stress and neuroinflammation. …
View article: “Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat
“Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat Open
Tomato fruits defined as “golden” refer to a food product harvested at an incomplete ripening stage with respect to red tomatoes at full maturation. The aim of this study is to explore the putative influence of “golden tomato” (GT) on Meta…
View article: Manipulation of HSP70-SOD1 Expression Modulates SH-SY5Y Differentiation and Susceptibility to Oxidative Stress-Dependent Cell Damage: Involvement in Oxotremorine-M-Mediated Neuroprotective Effects
Manipulation of HSP70-SOD1 Expression Modulates SH-SY5Y Differentiation and Susceptibility to Oxidative Stress-Dependent Cell Damage: Involvement in Oxotremorine-M-Mediated Neuroprotective Effects Open
The differentiation of neural progenitors is a complex process that integrates different signals to drive transcriptional changes, which mediate metabolic, electrophysiological, and morphological cellular specializations. Understanding the…
View article: Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats
Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats Open
Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat diet (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring redox homeostasis in male Wistar rats,…
View article: Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus Open
Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, and epilepsy. However, the effect of seizures on Cx expression is controversial. The present stu…
View article: Role of Bioactive Molecules on Neuroprotection, Oxidative Stress, and Neuroinflammation Modulation
Role of Bioactive Molecules on Neuroprotection, Oxidative Stress, and Neuroinflammation Modulation Open
As the global population ages, the burden of neurodegenerative and neurological disorders is dramatically increasing [...]
View article: A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud
A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud Open
COronaVIrus Disease 2019 (COVID-19) is a newly emerging infectious disease that spread across the world, caused by the novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Despite the advancements in science that…
View article: Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23
Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23 Open
Guanine-based purines (GBPs) exert numerous biological effects at the central nervous system through putative membrane receptors, the existence of which is still elusive. To shed light on this question, we screened orphan and poorly charac…
View article: Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors Open
Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction with neural membranes has been described, GUO still is an orphan neuromodulator. It has been …
View article: Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration
Low-Density Lipoprotein Receptor-Related Protein 8 at the Crossroad between Cancer and Neurodegeneration Open
The low-density-lipoprotein receptors represent a family of pleiotropic cell surface receptors involved in lipid homeostasis, cell migration, proliferation and differentiation. The family shares common structural features but also has sign…
View article: Bidirectional Control between Cholesterol Shuttle and Purine Signal at the Central Nervous System
Bidirectional Control between Cholesterol Shuttle and Purine Signal at the Central Nervous System Open
Recent studies have highlighted the mechanisms controlling the formation of cerebral cholesterol, which is synthesized in situ primarily by astrocytes, where it is loaded onto apolipoproteins and delivered to neurons and oligodendrocytes t…