Valentina Palmieri
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View article: A smart nanocomposite bioactive inks for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis
A smart nanocomposite bioactive inks for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis Open
Craniosynostosis (CS), characterised by the premature fusion of cranial sutures, often results from aberrant activation of fibroblast growth factor receptor 2 (FGFR2), a major regulator of osteogenic differentiation in cranial mesenchyme. …
View article: Enhanced Microbial Sensing via Resazurin Reduction Catalyzed by Graphene Oxide, A Versatile Approach for Diagnostics and Electrochemical Applications
Enhanced Microbial Sensing via Resazurin Reduction Catalyzed by Graphene Oxide, A Versatile Approach for Diagnostics and Electrochemical Applications Open
Resazurin is a cell viability phenoxazine dye widely employed for bacterial monitoring, as its colorimetric and fluorometric conversion reflects microbial metabolic activity. In this work, we demonstrate that graphene oxide (GO), a two‐dim…
View article: 3D-Bioprinting of Stromal Vascular Fraction for Gastrointestinal Regeneration
3D-Bioprinting of Stromal Vascular Fraction for Gastrointestinal Regeneration Open
Intestinal disorders such as inflammatory bowel diseases (IBDs), Crohn’s disease, malabsorption syndromes, and gastrointestinal fistulae (GIFs) are often characterized by chronic inflammation, epithelial barrier disruption, impaired stroma…
View article: Isolation by dialysis and characterization of luminescent oxidized carbon nanoparticles from graphene oxide dispersions: a facile novel route towards a more controlled and homogeneous substrate with a wider applicability<sup>*</sup>
Isolation by dialysis and characterization of luminescent oxidized carbon nanoparticles from graphene oxide dispersions: a facile novel route towards a more controlled and homogeneous substrate with a wider applicability<sup>*</sup> Open
Graphene Oxide (GO) is a two-dimensional (2D) nanomaterial largely exploited in many fields. Its preparation, usually performed from graphite in an oxidant environment, generally affords 2D layers with a broad size distribution, with overo…
View article: Impact of different 2D materials on the efficacy of photothermal and photodynamic therapy in 3D-bioprinted breast cancer
Impact of different 2D materials on the efficacy of photothermal and photodynamic therapy in 3D-bioprinted breast cancer Open
The convergence of nanotechnology and tissue engineering has paved the way for innovative cancer treatments that leverage the unique light absorption properties of nanomaterials.
View article: Defining the immunological compatibility of graphene oxide-loaded PLGA scaffolds for biomedical applications
Defining the immunological compatibility of graphene oxide-loaded PLGA scaffolds for biomedical applications Open
Graphene oxide (GO), a carbon-based nanomaterial, presents significant potential across biomedical fields such as bioimaging, drug delivery, biosensors, and phototherapy. This study examines the effects of integrating GO into poly(lactic-c…
View article: Plant-Derived Extracellular Vesicles as a Novel Frontier in Cancer Therapeutics
Plant-Derived Extracellular Vesicles as a Novel Frontier in Cancer Therapeutics Open
Recent advancements in nanomedicine and biotechnology have unveiled the remarkable potential of plant-derived extracellular vesicles (PDEVs) as a novel and promising approach for cancer treatment. These naturally occurring nanoscale partic…
View article: Bridging the Gap: Integrating 3D Bioprinting and Microfluidics for Advanced Multi-Organ Models in Biomedical Research
Bridging the Gap: Integrating 3D Bioprinting and Microfluidics for Advanced Multi-Organ Models in Biomedical Research Open
Recent advancements in 3D bioprinting and microfluidic lab-on-chip systems offer promising solutions to the limitations of traditional animal models in biomedical research. Three-dimensional bioprinting enables the creation of complex, pat…
View article: Plant-derived extracellular nanovesicles: a promising biomedical approach for effective targeting of triple negative breast cancer cells
Plant-derived extracellular nanovesicles: a promising biomedical approach for effective targeting of triple negative breast cancer cells Open
Introduction: Triple negative breast cancer (TNBC), a highly aggressive subtype accounting for 15–20% of all breast cancer cases, faces limited treatment options often accompanied by severe side effects. In recent years, natural extracellu…
View article: Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection
Unraveling the potential of graphene quantum dots against Mycobacterium tuberculosis infection Open
Introduction The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains has underscored the urgent need for novel therapeutic approaches. Carbon-based nanomaterials, such as graphene oxide (GO), have shown potential in anti-T…
View article: Multifunctional scaffolds for biomedical applications: Crafting versatile solutions with polycaprolactone enriched by graphene oxide
Multifunctional scaffolds for biomedical applications: Crafting versatile solutions with polycaprolactone enriched by graphene oxide Open
The pressing need for multifunctional materials in medical settings encompasses a wide array of scenarios, necessitating specific tissue functionalities. A critical challenge is the occurrence of biofouling, particularly by contamination i…
View article: Slow and steady wins the race: Fractionated near-infrared treatment empowered by graphene-enhanced 3D scaffolds for precision oncology
Slow and steady wins the race: Fractionated near-infrared treatment empowered by graphene-enhanced 3D scaffolds for precision oncology Open
Surgically addressing tumors poses a challenge, requiring a tailored, multidisciplinary approach for each patient based on the unique aspects of their case. Innovative therapeutic regimens combined to reliable reconstructive methods can co…
View article: Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing
Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing Open
Used in hydrogels, patches, and smart bandages MXenes enhance antibacterial activity, promote tissue regeneration, and enable real-time monitoring, improving wound care and patient outcomes.
View article: The osteoconductive properties of graphene-based material surfaces are finely tuned by the conditioning layer and surface chemistry
The osteoconductive properties of graphene-based material surfaces are finely tuned by the conditioning layer and surface chemistry Open
The molecular layer that adsorbs on the biomaterial surface upon contacting body tissues and fluids, termed the conditioning layer (CL), influences cell behavior regulating scaffold integration and resilience in a patient-specific fashion.
View article: Near-infrared controlled release of mesenchymal stem cells secretome from bioprinted graphene-based microbeads for nerve regeneration
Near-infrared controlled release of mesenchymal stem cells secretome from bioprinted graphene-based microbeads for nerve regeneration Open
Nerve damage is a prevalent and debilitating condition with limited treatment options. Recent years have seen an increased incidence of neural damage due to factors such as aging populations and traumatic brain injuries. Addressing t…
View article: Unlocking the Stability of Reduced Graphene Oxide Nanosheets in Biological Media via Use of Sodium Ascorbate
Unlocking the Stability of Reduced Graphene Oxide Nanosheets in Biological Media via Use of Sodium Ascorbate Open
Graphene oxide and reduced graphene oxide (RGO) are carbon bidimensional nanomaterials largely exploited in biomedicine. Their unique interactions with eukaryotic and prokaryotic cells are used to obtain precise intracellular delivery, to …
View article: Carboxylated graphene quantum dots-mediated photothermal therapy enhances drug-membrane permeability, ROS production, and the immune system recruitment on 3D glioblastoma models
Carboxylated graphene quantum dots-mediated photothermal therapy enhances drug-membrane permeability, ROS production, and the immune system recruitment on 3D glioblastoma models Open
Graphene quantum dots (GQDs) are biocompatible nanoparticles employed in biomedical field, thanks to their size and photophysical properties. GQDs have shown the capability to cross biological barriers, including the blood–brain barrier, w…
View article: Evaluation of the Toxic Activity of the Graphene Oxide in the Ex Vivo Model of Human PBMC Infection with Mycobacterium tuberculosis
Evaluation of the Toxic Activity of the Graphene Oxide in the Ex Vivo Model of Human PBMC Infection with Mycobacterium tuberculosis Open
Graphene Oxide has been proposed as a potential adjuvant to develop improved anti-TB treatment, thanks to its activity in entrapping mycobacteria in the extracellular compartment limiting their entry in macrophages. Indeed, when administer…
View article: Curcumin-Functionalized Graphene Oxide Strongly Prevents Candida parapsilosis Adhesion and Biofilm Formation
Curcumin-Functionalized Graphene Oxide Strongly Prevents Candida parapsilosis Adhesion and Biofilm Formation Open
Candida parapsilosis is the major non-C. albicans species involved in the colonization of central venous catheters, causing bloodstream infections. Biofilm formation on medical devices is considered one of the main causes of healthcare-ass…
View article: Graphene oxide-mediated copper reduction allows comparative evaluation of oxygenated reactive residues exposure on the materials surface in a simple one-step method
Graphene oxide-mediated copper reduction allows comparative evaluation of oxygenated reactive residues exposure on the materials surface in a simple one-step method Open
Graphene Oxide (GO) is the oxidized form of graphene rich in surface groups comprising carbonyl, carboxyl, hydroxyl, and epoxy residues. The solubility in water makes GO an ideal material in the biomedical field though the plethora of synt…