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View article: Defined Composition of Culture Media Promotes Rodent Neonatal Cardiomyocyte Maturation and Enables Functional Neuro-Cardiac Co-Culture
Defined Composition of Culture Media Promotes Rodent Neonatal Cardiomyocyte Maturation and Enables Functional Neuro-Cardiac Co-Culture Open
Neonatal rodent cardiomyocytes (CMs) are a mainstay of in vitro cardiac research, yet their immature phenotype limits the study of key physiological processes such as excitation–contraction coupling (ECC) and sympathetic modulation. Here, …
View article: Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons
Neurotoxic Effect of Doxorubicin Treatment on Cardiac Sympathetic Neurons Open
Doxorubicin (DOXO) remains amongst the most commonly used anti-cancer agents for the treatment of solid tumors, lymphomas, and leukemias. However, its clinical use is hampered by cardiotoxicity, characterized by heart failure and arrhythmi…
View article: Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction
Nerve growth factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro‐cardiac junction Open
Sympathetic neurons densely innervate the myocardium with non‐random topology and establish structured contacts (i.e. neuro‐cardiac junctions, NCJ) with cardiomyocytes, allowing synaptic intercellular communication. Establishment of heart …
View article: Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery
Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery Open
Key points The heart is innervated by a dense sympathetic neuron network which, in the short term, controls chronotropy and inotropy and, in the long term, regulates cardiomyocyte size. Acute neurogenic control of heart rate is achieved lo…
View article: 440Neuro-cardiac communication in the acute and chronic regulation of heart function and structure occurs through direct intercellular coupling
440Neuro-cardiac communication in the acute and chronic regulation of heart function and structure occurs through direct intercellular coupling Open
Background: Moderate-intensity exercise (MIE) is recommended as a primary prevention for cardiovascular diseases in type-2 diabetic individuals.Unfortunately, current clinical guideline does not specify which exercise intensity is effectiv…
View article: Dynamics of neuroeffector coupling at cardiac sympathetic synapses
Dynamics of neuroeffector coupling at cardiac sympathetic synapses Open
Key points The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a q…
View article: Neuroeffector coupling in the heart: determinants of function and survival of cardiac sympathetic neurons
Neuroeffector coupling in the heart: determinants of function and survival of cardiac sympathetic neurons Open
Rationale: The sympathetic branch of the autonomic nervous system (ANS) operates continuous control on the function and structure of cardiac cells (Bers et al., 2009). In basal conditions, neuronal input to sino-atrial node (SAN) cardiomyo…
View article: Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy
Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy Open
Significance Mitochondrial calcium uniporter (MCU) is the core channel subunit of the mitochondrial Ca 2+ uniporter complex (MCUC) and contributes to the regulation of ATP production. Here, we identify that the adaptive and maladaptive rem…
View article: Sciences within European Young Researcher Community272The neuro-cardiac interaction defines an extracellular microdomain required for neurotrophic signaling273Gut microbiota is important in the development of angiotensin II driven arterial hypertension and vascular dysfunction in mice274Role of the mitochondrial protein Opa1 in the regulation of the cardiac sympathetic neuron physiology
Sciences within European Young Researcher Community272The neuro-cardiac interaction defines an extracellular microdomain required for neurotrophic signaling273Gut microbiota is important in the development of angiotensin II driven arterial hypertension and vascular dysfunction in mice274Role of the mitochondrial protein Opa1 in the regulation of the cardiac sympathetic neuron physiology Open
Purpose: Sympathetic neurons (SNs) innervate the myocardium with a defined topology that allows physiological modulation of cardiac activity. Limiting amounts of neurotrophins released by cardiac cells control SN viability and myocardial d…
View article: Moderated Poster Session - Heart245The involvement of TWEAK and FN14 in murine autoimmune myocarditis246Sympathetic neurons that innervate the heart locally modulate cardiomyocyte trophic and electrophysiological properties247W4R variant of CSRP3 leads to the expression of a novel alternate reading frame protein due to alternative splicing248Glucocorticoid intervention prenatally: effects on fetal heart maturation249Uncoupling of myofilament Ca2+-sensitivity from troponin I phosphorylation by hypertrophic and dilated cardiomyopathy mutations can be reversed by EGCG and related Hsp90 inhibitors250Investigating inherited HCM caused by SCO2 and PRKAG2 mutations using the patients' induced pluripotent stem cell-derived cardiomyocytes
Moderated Poster Session - Heart245The involvement of TWEAK and FN14 in murine autoimmune myocarditis246Sympathetic neurons that innervate the heart locally modulate cardiomyocyte trophic and electrophysiological properties247W4R variant of CSRP3 leads to the expression of a novel alternate reading frame protein due to alternative splicing248Glucocorticoid intervention prenatally: effects on fetal heart maturation249Uncoupling of myofilament Ca2+-sensitivity from troponin I phosphorylation by hypertrophic and dilated cardiomyopathy mutations can be reversed by EGCG and related Hsp90 inhibitors250Investigating inherited HCM caused by SCO2 and PRKAG2 mutations using the patients' induced pluripotent stem cell-derived cardiomyocytes Open
Background: Myocarditis, defined as an inflammation of the myocardium, can be caused by autoimmune reactions. To study these immune reactions our group developed a mouse model of experimental autoimmune myocarditis (EAM). Little is known a…