Valentine Mismetti
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View article: Tailoring oral anticoagulant treatment in the era of multi-drug therapies for PAH and CTEPH
Tailoring oral anticoagulant treatment in the era of multi-drug therapies for PAH and CTEPH Open
The use of oral anticoagulants in the management of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) presents distinct therapeutic challenges and benefits. In PAH, the benefits of oral anticoa…
View article: Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension
Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension Open
Background Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally have a poor pro…
View article: Medical management of pleural infection: Why not saline intrapleural lavage?
Medical management of pleural infection: Why not saline intrapleural lavage? Open
In the last two decades, significant effort has been performed to understand and manage pleural infections. However, pleural infection remains a major health issue associated with long hospitalization, high morbidity, and mortality rates. …
View article: Pulmonary Embolism in the Cancer Associated Thrombosis Landscape
Pulmonary Embolism in the Cancer Associated Thrombosis Landscape Open
In cancer patients, pulmonary embolism (PE) is the second leading cause of death after the cancer itself, most likely because of difficulties in diagnosing the disease due to its nonclassical presentation. The risk of PE recurrence and pos…
View article: Factor XI Inhibition for the Prevention of Venous Thromboembolism: An Update on Current Evidence and Future perspectives
Factor XI Inhibition for the Prevention of Venous Thromboembolism: An Update on Current Evidence and Future perspectives Open
During the past decade, emergence of direct oral anticoagulants (DOACs) has drastically improved the prevention of thrombosis. However, several unmet needs prevail in the field of thrombosis prevention, even in the DOACs' era. The use of D…
View article: Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier
Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier Open
Obstructive sleep apnea (OSA) is characterized by repeated episodes of intermittent hypoxia (IH) and is recognized as an independent risk factor for vascular diseases that are mediated by a multitude of mechanistic pathophysiological casca…
View article: Use of Anticoagulants in Patients with Pulmonary Hypertension
Use of Anticoagulants in Patients with Pulmonary Hypertension Open
Since the earliest works on the understanding of different forms of pulmonary hypertension, thrombosis has been involved in the pathophysiology of the disease, both in pulmonary arterial hypertension (PAH) and in chronic thromboembolic pul…
View article: Clinical long-term outcome of non-specific pleuritis (NSP) after surgical or medical thoracoscopy
Clinical long-term outcome of non-specific pleuritis (NSP) after surgical or medical thoracoscopy Open
In patients with histological diagnosis of NSP both VATS and MT showed similar and excellent results of false negative cases and negative predictive value in excluding malignant pleural disease.