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View article: The microRNA miR-132 is a key regulator of lymphatic vascular remodelling
The microRNA miR-132 is a key regulator of lymphatic vascular remodelling Open
Lymphangiogenesis (growth of new lymphatic vessels), and lymphatic remodelling more broadly, are important for disease progression in cancer, lymphedema and the pulmonary disease lymphangioleiomyomatosis. Multiple molecular pathways which …
View article: Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis
Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis Open
Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including …
View article: Modulation of Immunity by Lymphatic Dysfunction in Lymphedema
Modulation of Immunity by Lymphatic Dysfunction in Lymphedema Open
The debilitating condition known as secondary lymphedema frequently occurs after lymphadenectomy and/or radiotherapy for the treatment of cancer. These therapies can damage lymphatic vessels leading to edema, fibrosis, inflammation and dys…
View article: MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging
MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging Open
Our results demonstrate that age-dependent miR-29 upregulation is an adaptive mechanism that counteracts the expression of some aging-related phenotypes and its anti-aging activity is primarily exerted by regulating intracellular iron home…
View article: Additional file 11: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging
Additional file 11: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging Open
Supporting Data: Raw quantitative PCR data relative to Figs. 1b and 6câ e, g, h. (XLSX 50 kb)
View article: Additional file 5: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging
Additional file 5: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging Open
Complete list of genes coherently or incoherently regulated by aging and sponge-29. (XLSX 43 kb)
View article: Additional file 3: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging
Additional file 3: of MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging Open
RNA-seq data analysis (DEG list). (XLSX 156 kb)
View article: MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging
MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging Open
Iron is an essential metal cofactor for enzymes involved in many cellular functions such as energy generation and cell proliferation. However, excessive iron concentration leads to increased oxidative stress and toxicity. As such, iron hom…