Explanipedia

Revascularization Treatment of Basilar Artery Occlusion in Patients with Mild‐to‐Moderate Severe Stroke Open

Simone Lieschke, Simon Hellwig, Christoph Riegler, Christian H. Nolte, Jan F. Scheitz , et al. · 2025

BACKGROUND The benefit of endovascular thrombectomy (EVT) in patients with basilar artery occlusion and severe neurological deficits is well established. However, its effectiveness in those with mild‐to‐moderate deficits remains uncertain.…

Long-Term Risk of Recurrent Cervical Artery Dissection and Stroke After Pregnancy Open

Sandro Fischer, Josefin E. Kaufmann, Tiina M. Metso, Turgut Tatlisumak, Johannes Wischmann , et al. · 2025

Importance Cervical artery dissection (CeAD) is a leading cause of stroke in young people and can occur during pregnancy. In women with prior CeAD, it is unclear whether future pregnancies increase the risk of recurrent CeAD, stroke, or de…

Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment Open

João Pedro Marto, Davide Strambo, George Ntaios, Thanh N. Nguyen, Paweł Wrona , et al. · 2025

Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis Open

Valerian Altersberger, Johannes Kaesmacher, Leonid Churilov, Vignan Yogendrakumar, Jan Gralla , et al. · 2025

Background Whether bridging thrombolysis with tenecteplase is beneficial compared with thrombectomy alone in patients who had a stroke with large-vessel occlusion remains unclear. Methods This is a causal inference study of observational d…

Intravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration Open

Miranda Nybondas, Nicolas Martinez‐Majander, Peter A. Ringleb, Matthias N. Ungerer, Christoph Gumbinger , et al. · 2024

Background and aims: Previous observational data indicate that young adults treated with intravenous thrombolysis (IVT) for acute ischemic stroke have more favorable outcomes and less complications when compared to older adults. Given the …

Atherosclerosis in patients with cervical artery dissection Open

Eveline Brunner, Josefin E. Kaufmann, Sandro Fischer, Henrik Gensicke, Annaelle Zietz , et al. · 2024

Introduction: Cervical artery dissection (CeAD) is considered a non-atherosclerotic arteriopathy, but atherosclerosis of the cervical arteries may co-exist. We explored the frequency and clinical importance of co-existent atherosclerosis i…

Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes Open

Davide Strambo, João Pedro Marto, George Ntaios, Thanh N. Nguyen, Patrik Michel , et al. · 2023

BACKGROUND: The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcom…

CADMUS Open

Martina Goeldlin, Madlaine Mueller, Bernhard Siepen, Wenpeng Zhang, Hatice Özkan , et al. · 2023

CADMUS, a novel MRI-based classification for SVD-associated ICH, is feasible and reproducible and may improve the classification of ICH subtypes in clinical practice and research.

P11.69.B INTRAVENOUS THROMBOLYSIS WITH OR WITHOUT ENDOVASCULAR TREATMENT FOR SUSPECTED ISCHEMIC STROKE IN PATIENTS WITH INTRACRANIAL TUMORS Open

Katharina Seystahl, Nicolas Martinez‐Majander, Alexander Salerno, Boris Modrau, Hebun Erdur , et al. · 2023

BACKGROUND: AND OBJECTIVES Intravenous thrombolysis (IVT) for suspected ischemic stroke in patients with intracranial neoplasms is off-label. However, data on risks of intracranial hemorrhage (ICH) is scarce. METHODS In a multicenter regis…

IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors Open

Katharina Seystahl, Nicolas Martinez‐Majander, Alexander Salerno, Morin Beyeler, Hebun Erdur , et al. · 2023

In our dataset from routine clinical care, we provide insights on the safety of IVT for suspected ischemic stroke in patients with intracranial tumors, a population that is commonly withheld thrombolysis in clinical practice and prospectiv…

Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study Open

Philipp Baumgartner, Lucas Kook, Valerian Altersberger, Henrik Gensicke, Elena Ardila-Jurado , et al. · 2023

Background: Retinal artery occlusion (RAO) may lead to irreversible blindness. For acute RAO, intravenous thrombolysis (IVT) can be considered as treatment. However, due to the rarity of RAO, data about IVT safety and effectiveness is limi…

The impact of competing stroke etiologies in patients with atrial fibrillation Open

Annaelle Zietz, Alexandros A. Polymeris, Fabrice Helfenstein, Sabine Schaedelin, Lisa Hert , et al. · 2023

Background: Data on the impact of competing stroke etiologies in stroke patients with atrial fibrillation (AF) are scarce. Methods: We used prospectively obtained data from an observational registry (Novel-Oral-Anticoagulants-in-Ischemic-S…

Intravenous Thrombolysis 4.5–9 Hours After Stroke Onset: A Cohort Study from the <span>TRISP</span> Collaboration Open

Valerian Altersberger, Gerli Sibolt, Lukas Enz, Christian Hametner, Jan F. Scheitz , et al. · 2023

Objective To investigate the safety and effectiveness of intravenous thrombolysis (IVT) >4.5–9 hours after stroke onset, and the relevance of advanced neuroimaging for patient selection. Methods Prospective multicenter cohort study from th…

Mechanical Thrombectomy Versus Best Medical Treatment in the Late Time Window in Non-DEFUSE-Non-DAWN Patients: A Multicenter Cohort Study Open

Tolga Dittrich, Peter B. Sporns, Lilian Kriemler, Salome Rudin, Anh Nguyên , et al. · 2023

Background: We assessed the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting in the late time window not fulfilling the DEFUSE-3 (Thrombectomy for Stro…

Apical pulmonary lesions suspected of malignancy visible on neck CT angiography performed for acute stroke: Prevalence, treatment, and clinical implications – the PLEURA study Open

Tolga Dittrich, Mara Aujesky, Salome Rudin, Annaelle Zietz, Benjamin Wagner , et al. · 2023

Background: Computed tomography angiography (CTA) of the supraaortic arteries is commonly used for acute stroke workup and may reveal apical pulmonary lesions (APL). Aim: To determine the prevalence, follow-up algorithms, and in-hospital o…

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants Open

Thomas R. Meinel, Duncan Wilson, Henrik Gensicke, Jan F. Scheitz, Peter A. Ringleb , et al. · 2023

Importance International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of a direct oral anticoagulant (DOAC). Objective To determine the risk of symptomatic intracran…

Global Cortical Atrophy Is Associated with an Unfavorable Outcome in Stroke Patients on Oral Anticoagulation Open

Marta Kubacka, Annaelle Zietz, Sabine Schaedelin, Alexandros A. Polymeris, Lisa Hert , et al. · 2022

Introduction: Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and cerebral microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC)…

A New Organotypic 3D Slice Culture of Mouse Meibomian Glands Reveals Impact of Melanocortins Open

Ingrid Zahn, Fabian Garreis, Martin Schicht, Vera Rötzer, Jens Waschke , et al. · 2022

The meibomian glands (MGs) within the eyelids produce a lipid-rich secretion that forms the superficial layer of the tear film. Meibomian gland dysfunction (MGD) results in excessive evaporation of the tear film, which is the leading cause…

Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 Open

João Pedro Marto, Davide Strambo, George Ntaios, Thanh N. Nguyen, Roman Herzig , et al. · 2022

The study was registered under ClinicalTrials.gov identifier NCT04895462.

Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration Open

Valerian Altersberger, Norman Rusche, Nicolas Martinez‐Majander, Christian Hametner, Jan F. Scheitz , et al. · 2022

Background: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely influence individual …

Impact of type of oral anticoagulants in patients with cerebral microbleeds after atrial fibrillation-related ischemic stroke or TIA: Results of the NOACISP-LONGTERM registry Open

Benjamin Wagner, Lisa Hert, Alexandros A. Polymeris, Sabine Schaedelin, Johanna M. Lieb , et al. · 2022

Background Cerebral microbleeds (CMBs) may have a differential impact on clinical outcome in stroke patients with atrial fibrillation (AF) treated with different types of oral anticoagulation (OAC). Methods Observational single-center stud…

Thrombolysis in stroke patients with elevated inflammatory markers Open

Valerian Altersberger, Lukas Enz, Gerli Sibolt, Christian Hametner, Stefania Nannoni , et al. · 2022

Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation Open

Alexandros A. Polymeris, Annaelle Zietz, Fabian Schaub, Louisa Meya, Christopher Traenka , et al. · 2022

Background: Data on the safety and effectiveness of once-daily (QD) versus twice-daily (BID) direct oral anticoagulants (DOAC) in comparison to vitamin K antagonists (VKA) and to one another in patients with atrial fibrillation (AF) and re…

Effect of admission time on provision of acute stroke treatment at stroke units and stroke centers—An analysis of the Swiss Stroke Registry Open

Valerian Altersberger, Patrick R. Wright, Sabine Schaedelin, Gian Marco De Marchis, Henrik Gensicke , et al. · 2022

Introduction: Rapid treatment of acute ischemic stroke (AIS) depends on sufficient staffing which differs between Stroke Centers and Stroke Units in Switzerland. We studied the effect of admission time on performance measures of AIS treatm…

Ischemic stroke in COVID‐19 patients: Mechanisms, treatment, and outcomes in a consecutive Swiss Stroke Registry analysis Open

Davide Strambo, Gian Marco De Marchis, Leo H. Bonati, Marcel Arnold, Emmanuel Carrera , et al. · 2021

Background Most case series of patients with ischemic stroke (IS) and COVID‐19 are limited to selected centers or lack 3‐month outcomes. The aim of this study was to describe the frequency, clinical and radiological features, and 3‐month o…

Oral Anticoagulants in Atrial Fibrillation Patients With Recent Stroke Who Are Dependent on the Daily Help of Others Open

Louisa Meya, Alexandros A. Polymeris, Sabine Schaedelin, Fabian Schaub, Valerian Altersberger , et al. · 2021

Background and Purpose: Data on the effectiveness and safety of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in patients with stroke attributable to atrial fibrillation (AF) who were dependent on the daily help of…

Maintenance of Acute Stroke Care Service During the COVID-19 Pandemic Lockdown Open

Valerian Altersberger, Lotte J. Stolze, Mirjam R. Heldner, Hilde Hénon, Nicolas Martinez‐Majander , et al. · 2021

Background and Purpose: Timely reperfusion is an important goal in treatment of eligible patients with acute ischemic stroke. However, during the coronavirus disease 2019 (COVID-19) pandemic, prehospital and in-hospital emergency procedure…

Aspirin versus anticoagulation in cervical artery dissection (TREAT-CAD): an open-label, randomised, non-inferiority trial Open

Stefan T. Engelter, Christopher Traenka, Henrik Gensicke, Sabine Schaedelin, Andreas R. Luft , et al. · 2021

Prior Dual Antiplatelet Therapy and Thrombolysis in Acute Stroke Open

Valerian Altersberger, Rolf Sturzenegger, Silja Räty, Christian Hametner, Jan F. Scheitz , et al. · 2020

Effect of haemoglobin levels on outcome in intravenous thrombolysis-treated stroke patients Open

Valerian Altersberger, Lars Kellert, Abdulaziz S. Al Sultan, Nicolas Martinez‐Majander, Christian Hametner , et al. · 2019

Introduction Alterations in haemoglobin levels are frequent in stroke patients. The prognostic meaning of anaemia and polyglobulia on outcomes in patients treated with intravenous thrombolysis is ambiguous. Patients and methods In this pro…

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