Valerie Plajer
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View article: <i>Rroid2</i> regulates effector-to-memory CD8 <sup>+</sup> T cell differentiation during infection in vivo
<i>Rroid2</i> regulates effector-to-memory CD8 <sup>+</sup> T cell differentiation during infection in vivo Open
CD8 + T cell differentiation has been associated with changes in the expression of long noncoding RNAs (lncRNAs). Yet, which and how lncRNAs regulate CD8 + T cell responses following infection in vivo remains incompletely understood. We pe…
View article: Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection
Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection Open
Virus-specific CD4 + T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV). Using this model pathogen, we performed an in-depth anal…
View article: D-Lactate drives cytotoxicity in Th1 cells by limiting mitochondrial ROS production through enhanced glyoxalase system activity
D-Lactate drives cytotoxicity in Th1 cells by limiting mitochondrial ROS production through enhanced glyoxalase system activity Open
L-lactate, long considered a byproduct of the glycolytic shift in activated CD4 + T cells, has been shown to impact T-cell differentiation and cytokine production. However, D-lactate’s role in immunity remains poorly understood. Here we co…
View article: KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity Open
View article: Humanized mouse model supports development, function, and tissue residency of human natural killer cells
Humanized mouse model supports development, function, and tissue residency of human natural killer cells Open
Significance Humanized mice represent a promising approach to study the human immune system in health and disease. However, insufficient development and function of human lymphocytes limit the applicability of humanized mice for cancer bio…